Daily Journal Digest — 2026-07-03¶
過去 24 小時新增:Transplant ID × 17、One Health × 14、Food Security × 12,共 43 篇。
⭐ 今日亮點¶
- Global, regional, and national burden of tuberculosis and multidrug-resistant tuberculosis by HIV status, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023
全球TB與MDR-TB防治落後的關鍵全景 - Diagnostic criteria for invasive pulmonary aspergillosis in COPD patients
填補COPD相關IPA的診斷與治療門檻 - Real-world use of maribavir for refractory CMV infection and intolerance to conventional anti-CMV agents after allogeneic hematopoietic cell transplantation
maribavir 救援難治型 CMV,停藥易復發
🔬 深入評讀¶
Global, regional, and national burden of tuberculosis and multidrug-resistant tuberculosis by HIV status, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023¶
Lancet Infect Dis | IF 27.0 | DOI
- 設計:GBD 2023系統性分析整合204個國家與地區的生命統計、監測、verbal autopsy及組織採樣資料;以CODEm、DisMod-MR 2.1與PAF估算1990–2023年TB負擔。
- 樣本:分析全球各年齡與性別人口,並依HIV及drug-resistance狀態分層;另評估吸菸、飲酒與高空腹血糖可歸因負擔。
- 關鍵數字:2023年估計有911萬例TB、122萬人死亡及5,460萬DALYs;其中MDR-TB占46.6萬例與10.2萬人死亡。2015–2023年incidence僅下降19.2%、死亡下降22.6%,距WHO 2035年分別下降90%與95%的目標甚遠,且MDR-TB改善幅度更小。
- Limitation:結果高度依賴模型、各國資料完整度及drug-resistance分類假設;MDR-TB incidence的95% uncertainty interval達19.8萬至108萬例,顯示資料稀疏地區的不確定性很大。
- Bottom line:TB防治不能只延續既有速度;HIV、MDR-TB、代謝與行為風險及全球衛生資金波動必須納入同一套韌性策略。
Diagnostic criteria for invasive pulmonary aspergillosis in COPD patients¶
Am J Respir Crit Care Med | DOI
- 設計:2026 年國際專家 Workshop/共識建議,依既有文獻擬定非呼吸器使用 COPD 病人之 IPA 診斷標準,再由另一組專家以 Delphi 法評估;原文未交代國家數、專家人數、文獻搜尋期間或 Delphi 輪次。
- 樣本:本研究並非收案型實證研究,未提供樣本數、比較組或追蹤時間;適用族群為 COPD 急性惡化住院且未使用呼吸器者,背景資料指出其 IPA 發生率約 1–4%,全球 COPD 人口逾 4 億。
- 關鍵數字:若病人具全身性或高劑量吸入型 corticosteroids、支氣管擴張症、糖尿病、心血管疾病或長期抗生素療程等至少 2 項風險因子,建議接受胸部 CT,並以呼吸道檢體進行真菌直接鏡檢、高容量培養及最好加做 Aspergillus PCR,另檢驗 serum galactomannan 與 Aspergillus IgG。高風險宿主加相符影像,且 Aspergillus 有任 2 項陽性結果,即建議視為足以啟動抗黴菌治療或納入研究的 IPA;此門檻臨床影響大,但全文未提供 sensitivity、specificity、OR、HR 或 CI,穩健性仍無法量化。
- Limitation:標準主要來自文獻與專家共識,且未報告系統性搜尋方法、證據分級、Delphi 的專家 n、輪次及同意比例;多數檢驗在 COPD 族群的效能資料不足,也尚未以前瞻性外部族群驗證。另此處提供的是 accepted manuscript 摘要而非可存取的完整 PDF,無法評估完整方法與利益衝突細節。
- Bottom line:COPD 急性惡化住院者的 IPA 基礎發生率雖僅 1–4%,但具至少 2 項風險因子時應及早做 CT 與多模式 Aspergillus 檢驗;「相符影像+2 項陽性檢驗」可作治療門檻,但目前仍屬待驗證的共識標準。
Real-world use of maribavir for refractory CMV infection and intolerance to conventional anti-CMV agents after allogeneic hematopoietic cell transplantation¶
Transplant Cell Ther | IF 3.4 | DOI
- 設計:單中心回溯性研究,納入2024年6月至2025年12月連續接受初次maribavir療程的成人allo-HCT病人;適應症為傳統抗CMV藥物治療無效或無法耐受。
- 樣本:共33人,其中30人有CMV viremia、4人有腸胃道CMV disease,1人兩者兼具;maribavir療程中位20日,追蹤中位9.7個月,未設比較組。
- 關鍵數字:30名CMV viremia病人中27人清除病毒血症(90%),中位清除時間11日;停藥後27名初始反應者有19人復發(70%),中位31日。復發後有14/16人對再次治療產生反應,且未觀察到明顯血液或腎毒性;但研究未提供CI或校正後效應量。
- Limitation:單中心、樣本小且回溯性,缺乏比較組,容易受適應症選擇、既往治療及監測頻率造成的confounding影響;療程長度差異極大,亦無法據此判定最佳停藥時點或對CMV disease的療效。
- Bottom line:Maribavir可作為allo-HCT後傳統抗CMV治療無效或不耐受時的低骨髓與腎毒性選項,但停藥後早期復發極常見,須安排密集CMV監測並預先規劃再次治療。
🔴 Transplant & Opportunistic Infections¶
Community-based tuberculosis screening with computer-aided detection technology alone and in combination with point-of-care C-reactive protein testing: a paired screen-positive trial¶
Authors: Reither K et al. | Journal: Lancet Infect Dis | Date: 2026 Jul 01
DOI: 10.1016/S1473-3099(26)00222-7
TL;DR: 社區篩檢20,023人,CAD加CRP較CAD單用少檢出tuberculosis病例(82.2%比94.5%),且每案成本高37.3%,未達non-inferiority。
不嘻嘻:多加一項檢驗,反而更貴又漏更多,這算精準踩雷。
Global, regional, and national burden of tuberculosis and multidrug-resistant tuberculosis by HIV status, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023¶
Authors: | Journal: Lancet Infect Dis | Date: 2026 Jul 01
DOI: 10.1016/S1473-3099(26)00295-1
TL;DR: 2023年全球估計有911萬例tuberculosis及122萬人死亡;2015至2023年incidence僅降19.2%、死亡降22.6%,距WHO目標仍遠。
不嘻嘻:結核病照這速度退場,WHO目標大概得先學會等。
Liver function impairment and associated factors among adult human immunodeficency virus infected individuals on antiretroviral therapy at Hosanna town, Central Ethiopia¶
Authors: Abebe S et al. | Journal: BMC Infect Dis | Date: 2026 Jul 01
DOI: 10.1186/s12879-026-13915-1
TL;DR: 衣索比亞307名接受ART的HIV成人中,19.2%有Grade I肝功能異常;HBsAg陽性、草藥及anti-tuberculosis drugs使用之AOR分別為4.03、4.46、3.60。
不嘻嘻:ART之外還有肝臟副本,草藥也來友情客串。
Prevalence and kinetics of viral infections during the first 100 days after pediatric hematopoietic stem cell transplantation at the Children's Hospital in Rabat¶
Authors: Hassaine M et al. | Journal: BMC Infect Dis | Date: 2026 Jul 01
DOI: 10.1186/s12879-026-13527-9
TL;DR: 摩洛哥33名兒童HSCT病人中,CMV檢出率51.5%,首次reactivation中位3週;EBV多於第1–7週短暫reactivation,BK virus則於第1–4週達高峰並與hemorrhagic cystitis相關。
不嘻嘻:移植後百日像病毒輪班表,一個下班一個報到。
Real-world use of maribavir for refractory CMV infection and intolerance to conventional anti-CMV agents after allogeneic hematopoietic cell transplantation¶
Authors: Nishiyama R et al. | Journal: Transplant Cell Ther | Date: 2026 Jul 01
DOI: 10.1016/j.jtct.2026.06.049
TL;DR: 33名allo-HCT病人使用maribavir後,CMV viremia清除率90%,中位11日;停藥後70%於中位31日復發,但多數再次治療有效,且無顯著血液或腎毒性。
嘻嘻:maribavir清場俐落又少毒性,可惜CMV很愛回鍋。
Accelerated immunosenescence in SLE: current evidence and clinical translation¶
Authors: Li Q et al. | Journal: Front Immunol | Date: 2026
DOI: 10.3389/fimmu.2026.1830804
TL;DR: SLE呈現提早出現的immunosenescence,包括senescent-like免疫細胞擴增、telomere縮短及epigenetic age加速;現階段相關指標仍僅適合作為研究biomarker。
不嘻嘻:SLE連免疫老化都提早,只是biomarker還沒能臨床上班。
Fatal Rhinocerebral Mucormycosis and Aspergillus flavus Coinfection Complicated by Internal Carotid Artery Arteritis: A Case Report¶
Authors: Ansari M et al. | Journal: Case Rep Med | Date: 2026
DOI: 10.1155/carm/9945781
TL;DR: 63歲糖尿病男性發生rhinocerebral mucormycosis合併A. flavus感染,侵犯cavernous sinus與internal carotid artery並造成多發腦梗塞;手術及高劑量liposomal amphotericin B仍未能挽救。
不嘻嘻:兩種侵襲性黴菌聯手,連血管與手術都守不住。
Clinical presentation, management, and outcomes of post-transplant lymphoproliferative disorder in renal and pancreas transplantation: a 22-year experience¶
Authors: Emami K et al. | Journal: Front Transplant | Date: 2026
DOI: 10.3389/frtra.2026.1830197
TL;DR: 73例腎臟或胰臟移植後PTLD中,56%於移植逾10年才確診,整體EBV陽性率57%;75%達remission,1年及5年overall survival分別為83%與68%。
嘻嘻:PTLD雖會遲到多年,多數病人仍有機會達到remission。
Combination Antifungal Therapy and Formulary Optimization for Progressive Invasive Pulmonary Aspergillosis in a Pediatric Patient With Acute Myeloid Leukemia: A Case Report¶
Authors: Khamis F et al. | Journal: Clin Case Rep | Date: 2026 Jul
DOI: 10.1002/ccr3.73041
TL;DR: 兒童AML病人的progressive invasive pulmonary aspergillosis,在併用antifungal therapy並改用原廠liposomal amphotericin B後影像改善,凸顯製劑選擇可能影響療效。
嘻嘻:抗黴菌藥不只成分重要,製劑品質也可能左右戰局。
Assessment of Bedside-Adaptable Models to Predict Molecular Sepsis Subtypes in a Resource-Limited Setting: A Multicenter Analysis from Uganda¶
Authors: Bakamutumaho B et al. | Journal: medRxiv | Date: 2026 Apr 09
DOI: 10.64898/2026.04.08.26350396
TL;DR: 烏干達sepsis cohort中,床邊clinical model預測transcriptomic及proteomic subtype的AUROC為0.75與0.73;加入HIV、malaria及tuberculosis快篩後幾無改善,無法單獨取代molecular assay。
嘻嘻:資源有限時床邊模型已有方向感,只是還不能冒充molecular assay。
Impact of pre-transplantation exposure to immunosuppressive agents on lung transplant outcomes in interstitial lung disease¶
Authors: Tazibet K et al. | Journal: Transpl Int | Date: 2026
DOI: 10.3389/ti.2026.16549
TL;DR: 209名ILD肺移植病人中,移植前一年使用non-steroidal immunosuppressive agents者,12個月免再移植存活率較低(62%比80%;HR 1.99),且pneumonia與CMV viremia較多。
不嘻嘻:移植前免疫抑制的帳,肺移植後還是會連本帶利來收。
Spirometry after treatment completion for pulmonary tuberculosis - a necessity?¶
Authors: Chakraborty S et al. | Journal: Monaldi Arch Chest Dis | Date: 2026 Jul 01
DOI: 10.4081/monaldi.2026.3904
TL;DR: 175名完成pulmonary tuberculosis治療未滿一年者,57.1%仍有spirometry異常,以restrictive pattern最多(30.3%);異常多不可逆,支持療程結束時常規檢測肺功能。
不嘻嘻:病菌治好了,肺功能卻常沒跟著畢業。
Short communication: Excretory-secretory antigens allow effective IgG detection in experimental Strongyloides hyperinfection under immunosuppression¶
Authors: Carvalho EFG et al. | Journal: J Helminthol | Date: 2026 Jul 02
DOI: 10.1017/S0022149X26101692
TL;DR: 免疫抑制大鼠的急性Strongyloides venezuelensis hyperinfection模型中,RPMI excretory-secretory antigen偵測IgG表現最佳,且未與未感染對照產生反應,具高風險篩檢潛力。
嘻嘻:免疫抑制下仍抓得到IgG,篩檢Strongyloides多了一線希望。
TTP-like syndrome revealing advanced HIV infection: a case of secondary multifactorial thrombotic microangiopathy¶
Authors: Marrone A et al. | Journal: MedScience | Date: 2026 Jul 01
DOI: 10.1007/s11684-026-1234-y
TL;DR: 45歲女性因TTP-like syndrome就醫,ADAMTS13正常而確診晚期HIV,並有EBV及HHV-8 viremia;即使接受plasma exchange與ART,仍因multifactorial secondary TMA死亡。
不嘻嘻:TMA只是煙霧彈,背後多重病毒才是真正的圍毆。
Early versus standard anti-thymocyte globulin administration in haploidentical transplantation using post-transplant cyclophosphamide: a pilot comparative study¶
Authors: Kheiri G et al. | Journal: Ann Hematol | Date: 2026 Jul 01
DOI: 10.1007/s00277-026-07147-1
TL;DR: 36名haplo-PBSCT病人中,提早或標準時程給予ATG的90日CMV reactivation相近(55.6%比59.3%);提早給藥可加速neutrophil及platelet engraftment,但樣本不足以判定優越性。
嘻嘻:提早ATG或許能讓engraftment快些,先等大研究補證據。
Syndemics, violence and injury: exploring historical relationships between infectious disease epidemics and violent crime in South Africa¶
Authors: Brodie NR | Journal: Int J Inj Contr Saf Promot | Date: 2026 Jul 01
DOI: 10.1080/17457300.2026.2689077
TL;DR: 南非歷次Spanish Flu、tuberculosis、HIV及COVID-19 epidemic後,除gendered violence外,未見暴力犯罪快速或持續增加;COVID-19後增幅可能較與lockdown及酒精限制相關。
嘻嘻:epidemic未必直接催生暴力,至少因果關係沒有亂扣帽子。
Diagnostic criteria for invasive pulmonary aspergillosis in COPD patients¶
Authors: Denning DW et al. | Journal: Am J Respir Crit Care Med | Date: 2026 Jul 01
DOI: 10.1093/ajrccm/aamag310
TL;DR: 住院COPD急性惡化若具至少兩項risk factor,應接受胸部CT及多項Aspergillus檢驗;高風險、影像相符且任兩項檢驗陽性,即足以診斷IPA並開始antifungal therapy。
嘻嘻:COPD的IPA診斷終於有較能落地的臨床路徑。
🟢 One Health / Zoonoses¶
Beyond H5N1: Influenza A virus infection in bovine udder organoids¶
Authors: Fritsch H et al. | Journal: Emerg Microbes Infect | Date: 2026 Jul 02
DOI: 10.1080/22221751.2026.2698239
TL;DR: 牛乳腺organoid可被禽、豬及人類Influenza A virus有效感染;哺乳類H1N1複製效率與牛H5N1相近,而低病原性H9N2受限,顯示乳腺tropism具subtype差異。
不嘻嘻:H5N1之外還有其他Influenza A盯上乳腺,驚喜包真多。
Building resilient food safety systems through a One Health approach to prepare for the next pandemic¶
Authors: Di Martino M et al. | Journal: NPJ Sci Food | Date: 2026 Jul 01
DOI: 10.1038/s41538-026-00798-4
TL;DR: pandemic不僅源自人、動物與環境交互作用,也會破壞food safety與農糧供應鏈;整合One Health surveillance、跨部門治理及韌性規劃,是下一次pandemic preparedness核心。
不嘻嘻:下一場pandemic還沒來,糧食系統已先收到警告信。
High quality Chromosome-scale Genome Assembly of Phlebotomus perniciosus, a Vector of Zoonotic Leishmaniasis¶
Authors: Thorpe J et al. | Journal: Sci Data | Date: 2026 Jul 01
DOI: 10.1038/s41597-026-07617-1
TL;DR: 建立Phlebotomus perniciosus 143 Mb chromosome-scale genome,scaffold N50達48 Mb、BUSCO完整度95%,並註解12,492個gene,可支援leishmaniasis vector biology與surveillance研究。
嘻嘻:高品質vector genome到位,leishmaniasis研究工具箱升級了。
Prevalence and detection of Brucella infection in people with fever of unknown origin in Inner Mongolia, China¶
Authors: Zhang T et al. | Journal: Front Cell Infect Microbiol | Date: 2026
DOI: 10.3389/fcimb.2026.1838461
TL;DR: 中國內蒙古335名發燒病人中,Brucella檢出率15.5%;266名FUO病人中占15.0%,且與牲畜接觸史無關,加入qPCR可減少單靠serology造成的漏診。
不嘻嘻:沒有牲畜接觸史也躲不掉Brucella,病史又少一張安全牌。
Avian paramyxovirus type 1-associated severe pneumonia in humans: Molecular characterization and zoonotic transmission risk¶
Authors: Liu B et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101501
TL;DR: 一名免疫功能正常65歲男性接觸病雞後罹患重症pneumonia;人、雞與環境檢體證實相同APMV-1 Class I genotype 1.1.2 1b,支持禽傳人及致命呼吸道感染潛力。
不嘻嘻:APMV-1也能把健康成人打進重症,禽類接觸史不能隨便略過。
Spatial and temporal associations between animal ownership and malaria prevalence in Africa using cross-sectional national Demographic and Health Surveys¶
Authors: Topazian HM et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101499
TL;DR: 非洲66項調查共392,843人顯示,飼養各類家畜與Plasmodium感染的整體OR為1.55–1.67,但時空分層後OR介於0.33–3.33,zooprophylaxis效果高度依賴在地情境。
不嘻嘻:養牲畜究竟擋蚊還是養瘧疾,答案依舊看地點抽卡。
Dog bite-associated pathogens: advances in pathogenic mechanisms and systemic clinical consequences in humans¶
Authors: Du L et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101496
TL;DR: 犬咬傷可接種多種菌造成cellulitis、sepsis、meningitis及endocarditis,RABV症狀出現後幾乎必死;即時傷口處置、適當antimicrobial及rabies post-exposure prophylaxis是降低死亡關鍵。
不嘻嘻:犬咬傷看似小洞,病原清單卻長得像會診名單。
Planetary health education in Africa: Building on longstanding One Health frameworks¶
Authors: Henley P et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101498
TL;DR: 非洲長期以One Health network、跨部門治理及教育實踐整合人、動物與環境健康;未來Planetary Health教育應建立於既有架構,並承認非洲機構的知識領導角色。
嘻嘻:Planetary Health若從既有One Health扎根,至少不用重造輪子。
A phylogeny-informed mathematical modeling of HPAI H5N1 transmission dynamics and effectiveness of control measures¶
Authors: Babasola O et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101490
TL;DR: phylogeny-informed模型顯示,高效且高涵蓋率vaccination可降低各宿主H5N1 reproduction threshold;合併環境清消與針對性撲殺家禽,對減少傳播及人類spillover最有效。
嘻嘻:vaccination加環境控制與精準撲殺,H5N1防線終於像套組。
Risk ranking and antimicrobial resistance of Shiga toxin-producing Escherichia coli of bovine origin¶
Authors: Bonardi S et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101497
TL;DR: 義大利150頭乳牛屠宰採樣中,STEC於皮毛及屠體盛行率為6.7%與4.0%;20株中75%屬較高致病風險群,15%帶ESBL gene,但高風險株均對azithromycin感受。
不嘻嘻:高風險STEC還帶ESBL gene,牛肉供應鏈又添一層焦慮。
Prevalence and Antimicrobial Susceptibility Patterns of Salmonella enterica Serovars Along the Dairy Value Chain: A One Health-Relevant Surveillance of Dairy Farms¶
Authors: Khan JA et al. | Journal: Foodborne Pathog Dis | Date: 2026 Jul 02
DOI: 10.1177/15353141261466779
TL;DR: 印度北部乳品供應鏈900件檢體中,Salmonella enterica serovars陽性率2%,主要來自地板、奶桶及生乳;73.7%抗ampicillin、68.4%抗tetracycline,48%為MDR。
不嘻嘻:乳品鏈的Salmonella不算多,抗藥性倒是一點也不客氣。
Occurrence of Multidrug-Resistant Salmonella spp. in Raw Meat Retailed in Wet Markets in Chattogram City, Bangladesh¶
Authors: Gupta MD et al. | Journal: Vet Med Sci | Date: 2026 Jul
DOI: 10.1002/vms3.71071
TL;DR: 孟加拉吉大港200件生肉中,Salmonella spp.盛行率13.5%,27株全為MDR;對sulfamethoxazole-trimethoprim抗藥率100%,blaTEM檢出率81.5%。
不嘻嘻:生肉裡的Salmonella全員MDR,濕市場直接開抗藥性同學會。
Food-Borne Diseases in Bangladesh: First Assessment of Knowledge, Attitudes, and Practices of Farmers¶
Authors: Ahmed MJ et al. | Journal: Vet Med Int | Date: 2026
DOI: 10.1155/vmi/3617712
TL;DR: 孟加拉523名畜牧農民中,僅8.8%具良好food-borne disease知識,38.2%有良好管理實務;即使多數態度正向,仍需強化訓練、社區衛教及One Health合作。
不嘻嘻:態度很正向、知識跟不上,food safety只能先靠運氣。
One Health Insights From Pteropus medius: Nipah Virus Spillover, Microbiota, and Antimicrobial Resistance¶
Authors: Chowdhury P et al. | Journal: Microbiologyopen | Date: 2026 Aug
DOI: 10.1002/mbo3.70362
TL;DR: Pteropus medius不僅是NiV reservoir,其microbiota與guano亦帶有ESBL-producing E. coli、Salmonella spp.等抗藥菌;棲地破碎、廢水及都市化同時推升spillover與AMR傳播。
不嘻嘻:蝙蝠不只帶NiV,連AMR也一起打包,One Health真忙。
🟡 Food Security / Food Safety¶
The TaMYB55-TaSnRK1α1-TabZIP9 module confers heat stress tolerance in wheat¶
Authors: Yang W et al. | Journal: Proc Natl Acad Sci U S A | Date: 2026 Jul 07
DOI: 10.1073/pnas.2601097123
TL;DR: 小麥TaMYB55活化TaSnRK1α1,後者磷酸化並促進TabZIP9降解,藉由調節reactive oxygen species homeostasis提升耐熱與穀粒重量;promoter A-to-G變異與耐熱表型共同分離。
嘻嘻:找到耐熱調控模組,氣候變遷下的小麥育種多了一張牌。
Molecularly imprinted carbon dots fluorescent probe for rapid and selective detection of ciprofloxacin in animal-derived food¶
Authors: Yang S et al. | Journal: Food Chem | Date: 2026 Jun 27
DOI: 10.1016/j.foodchem.2026.150199
TL;DR: CDs@MIP螢光探針可選擇性偵測ciprofloxacin,LOD為4.2 nM,於牛奶、蜂蜜及雞肉添加試驗回收率95.25%–101.25%,具快速food safety monitoring潛力。
嘻嘻:ciprofloxacin快篩又靈敏,food safety監測更接近現場使用。
Characterization of a method to detect hepatitis A virus and norovirus in meat products¶
Authors: Hennechart-Collette C et al. | Journal: Int J Food Microbiol | Date: 2026 Jun 27
DOI: 10.1016/j.ijfoodmicro.2026.111928
TL;DR: PEG沉澱法可由即食肉品回收HAV及norovirus;LOD50為HAV 1.53×10⁴ copies/g、norovirus GI/GII 13–61 copies/g,可用於肉品相關foodborne outbreak調查。
嘻嘻:肉品病毒回收方法成形,outbreak調查終於多一把實用工具。
Targeting Bacterial Quorum Sensing: Insights into Quorum Sensing Inhibitors and Innovative Antimicrobial Strategies for Enhancing Food Safety and Combating Antibiotic Resistance¶
Authors: Yang H et al. | Journal: J Agric Food Chem | Date: 2026 Jul 01
DOI: 10.1021/acs.jafc.5c17992
TL;DR: quorum sensing inhibitor可在不直接殺菌下抑制virulence與biofilm;結合nanotechnology、phage、CRISPR-Cas及multitarget策略,可能降低食源性細菌污染與antibiotic resistance。
嘻嘻:不殺菌也能拆virulence與biofilm,抗菌策略開始懂得繞路。
Changes in household food purchases in Iran: income and urban-rural inequality¶
Authors: Jafarvand E et al. | Journal: BMC Public Health | Date: 2026 Jul 01
DOI: 10.1186/s12889-026-28182-7
TL;DR: 伊朗2005–2022年城鄉家庭六大類食物、熱量及macronutrient人均購買量皆下降;城鄉與所得差距雖縮小,但反映整體food security惡化風險,需進一步政策評估。
不嘻嘻:差距縮小不是好消息,因為大家可能只是一起買不起。
A Sensitive and Rapid Detection Method for the Stx2 Gene of Escherichia coli O157:H7, based on the Combination of Colorimetric Loop-Mediated Isothermal Amplification (cLAMP) with CNN Deep Learning Model¶
Authors: Yuliawati et al. | Journal: Int J Infect Dis | Date: 2026 Jul 01
DOI: 10.1016/j.ijid.2026.108950
TL;DR: 偵測E. coli O157:H7 stx2的cLAMP最佳條件為60°C、25分鐘,LOD達14.7 fg;結合MobileNetV2 CNN後具有最高specificity、sensitivity及accuracy,適合POCT。
嘻嘻:cLAMP搭CNN快速判讀,POCT又更像真的能進現場。
Risk Ranking of Emerging Hazards in Fresh Produce and Cereal Grains under Climate Change using Multi-Criteria Decision Analysis (MCDA)¶
Authors: Stathas L et al. | Journal: J Food Prot | Date: 2026 Jul 01
DOI: 10.1016/j.jfp.2026.100849
TL;DR: 氣候變遷下歐盟蔬果及穀物hazard ranking以穀物Aspergillus mycotoxins最高,其次為葉菜相關Campylobacter spp.、Listeria monocytogenes、E. coli及Salmonella spp.。
不嘻嘻:氣候暖化還替mycotoxin與食源菌排好了危害榜。
Strain-Level Food Surveillance of Escherichia coli Using a Specific-Nonspecific Hybrid Sensor Array Strategy¶
Authors: Zhang Y et al. | Journal: Anal Chem | Date: 2026 Jul 02
DOI: 10.1021/acs.analchem.6c01811
TL;DR: specific-nonspecific hybrid sensor array可於1小時內辨識多種E. coli strain及混合物;在牛肉、牛奶等複雜基質中,KNN模型達100%分類準確率,兼具總量定量與strain-level鑑別。
嘻嘻:一小時辨識strain與混合物,食安監測終於有點偵探感。
Antioxidant characterisation of bean-to-bar dark chocolates: potential relationship with their endothelium-dependent vasorelaxation activity¶
Authors: Tabart J et al. | Journal: Food Funct | Date: 2026 Jul 02
DOI: 10.1039/d6fo00533k
TL;DR: 13款黑巧克力中,兩款厄瓜多手工產品的抗氧化力、flavan-3-ols及ex vivo vasorelaxation最佳;但每10克僅含102.3與90.0 mg,均未達EFSA健康宣稱所需200 mg。
不嘻嘻:黑巧克力確實有潛力,只是有效份量不太配合嘴饞。
Monitoring food spoilage biogenic amines utilizing a blue-emitting fluorescent ionic liquid¶
Authors: Tohora N et al. | Journal: Analyst | Date: 2026 Jul 02
DOI: 10.1039/d6an00340k
TL;DR: nTPND螢光探針可選擇性偵測spermidine與spermine,fluorometry LOD分別為36及59 nM;於蘑菇實品可藉藍轉綠螢光辨識腐敗釋出的biogenic amines。
嘻嘻:腐敗能用螢光變色現形,食物壞掉終於不用全靠鼻子。
Deletion of steD gene and yejAE operons in LPS-deficient Salmonella elicits strong t cell immunity and complete protection against homologous serotypes¶
Authors: Zhou G et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1827967
TL;DR: 刪除manA、steD及yejAE的LPS-deficient Salmonella Typhimurium活疫苗可誘發IgG、sIgA及Th1反應,使小鼠完全抵抗同源S. Typhimurium,並提高異源S. Enteritidis攻毒存活。
嘻嘻:活疫苗兼顧黏膜與T cell immunity,跨serovar保護也露曙光。
Integrated genomic and phenotypic characterization of representative Salmonella Pullorum and Salmonella Enteritidis isolated from a poultry farm¶
Authors: Ding L et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1845729
TL;DR: 同一雞場的Salmonella Enteritidis SA03較Salmonella Pullorum SA406具有更多AMR gene且毒力較高,LD50分別為10⁷·⁸與10⁸·⁵ CFU;genomic prediction與表型藥敏僅部分一致。
不嘻嘻:AMR gene與藥敏表型對不上,genome也不是萬能算命師。
資料來源:PubMed (articles retrieved 2026-07-03)