Daily Journal Digest — 2026-07-01¶
過去 24 小時新增:Transplant ID × 20、One Health × 14、Food Security × 15,共 49 篇。
⭐ 今日亮點¶
- 10-Year Trends in Attributable and Contributable Mortality of Culture-Positive Invasive Aspergillosis in Patients with Hematologic Malignancies: Have We Reached the "Ceiling Efficacy Effect" of Modern Antifungals?
重新界定侵襲性麴菌病的存活瓶頸 - Cytomegalovirus Interstitial Pneumonia: A Plague of Marrow Transplant That the Field Solved
回顧移植界如何攻克曾經必死的 CMV 間質性肺炎 - Reduced-dose post-transplant cyclophosphamide as graft-versus-host disease prophylaxis in matched donor allogeneic stem cell transplantation: a systematic review of efficacy and toxicity
直接挑戰HSCT的標準PTCy劑量
🔬 深入評讀¶
10-Year Trends in Attributable and Contributable Mortality of Culture-Positive Invasive Aspergillosis in Patients with Hematologic Malignancies: Have We Reached the "Ceiling Efficacy Effect" of Modern Antifungals?¶
Clin Infect Dis | IF 8.8 | DOI | [(Szvalb202610YearTrends?)]
- 設計:血液惡性腫瘤患者 culture-positive invasive aspergillosis 的 10 年趨勢研究,分別評估 attributable、contributable 與 all-cause mortality;原摘要未交代國家、中心數及確切年份。
- 樣本:納入經 culture 證實的 invasive aspergillosis 患者,但摘要未提供樣本數、血液疾病組成、移植比例或追蹤天數,亦無未感染比較組,限制外部效度判讀。
- 關鍵數字:10 年間 attributable mortality 下降,但 contributable 與 all-cause mortality 仍高;摘要未提供死亡率、年趨勢效應量或 95% CI,因此「ceiling efficacy effect」具臨床啟發性,卻無法由現有數字確認幅度與穩健性。
- Limitation:僅納入 culture-positive 病例,可能偏向菌量較高或較重症的族群,並漏掉大量 culture-negative probable invasive aspergillosis;死亡因果分為 3 層仍高度依賴 adjudication,且 10 年間癌症治療、診斷與 supportive care 的改變可能造成 confounding。
- Bottom line:當現代 antifungals 已使 attributable mortality 下降,下一階段不應只追求第 1 個新藥,而應把免疫重建、縮短 neutropenia 與宿主導向治療納入整體策略。
Cytomegalovirus Interstitial Pneumonia: A Plague of Marrow Transplant That the Field Solved¶
Transplant Cell Ther | IF 3.4 | DOI | [(Forman2026CytomegalovirusInterstitial?)]
- 設計:社論/歷史回顧,非原始研究;回顧異體骨髓移植早期 CMV 間質性肺炎(CMV-IP)從幾乎必死到獲得控制的歷程,並向病毒學先驅 Zaia 與 Myers 致敬。
- 樣本:無 cohort/樣本數;屬敘事性觀點文章,未做系統性文獻檢索。
- 關鍵論點:轉捩點在於 preemptive(監測導向)ganciclovir 抗病毒策略,加上 CMV 專一性 T 細胞免疫重建,而非單靠更強效的藥物。
- Limitation:社論性質,反映作者個人歷史視角,無量化數據、效應量或對照。
- Bottom line:CMV-IP 的攻克是移植感染史上少見的「完整勝利」,提醒後人宿主免疫重建與 preemptive 監測並重,往往比追求單一新藥更能改寫預後。
Reduced-dose post-transplant cyclophosphamide as graft-versus-host disease prophylaxis in matched donor allogeneic stem cell transplantation: a systematic review of efficacy and toxicity¶
Transplant Cell Ther | IF 3.4 | DOI | [(Shafqat2026Reduceddoseposttransplant?)]
- 設計:系統性回顧 MEDLINE、Embase、Cochrane CENTRAL 與 Google Scholar,比較 matched-related/matched-unrelated donor allogeneic HSCT 使用低於標準 100 mg/kg 的 PTCy;RCT 以 RoB 2.0、非隨機研究以 ROBINS-I 評估。
- 樣本:共納入 18 項研究,低劑量範圍為 40–90 mg/kg;摘要未提供總患者數及各研究追蹤期,而 8 項非隨機比較研究中有 5 項屬 critical risk of bias。
- 關鍵數字:低劑量 PTCy 的 acute GVHD、chronic GVHD 與存活大致與對照相近,並伴隨較少 CMV reactivation、出血性膀胱炎及較快 neutrophil、platelet engraftment;唯一 1 項 RCT 中,40 mg/kg PTCy 合併低劑量 ATG 甚至降低兩類 GVHD,但因介入同時改變,無法把效應單獨歸因於 PTCy 減量。
- Limitation:18 項研究在劑量、ATG 合併方式、donor 類型與 conditioning 上高度異質,且 5/8 非隨機研究有 critical bias;缺乏可合併的效應量、95% CI 與標準化感染定義,現階段不足以證明 non-inferiority。
- Bottom line:40–90 mg/kg PTCy 可視為值得進入大型 RCT 的減毒策略,但在取得足夠比較證據前,不宜全面取代 100 mg/kg 標準方案。
🔴 Transplant & Opportunistic Infections¶
10-Year Trends in Attributable and Contributable Mortality of Culture-Positive Invasive Aspergillosis in Patients with Hematologic Malignancies: Have We Reached the "Ceiling Efficacy Effect" of Modern Antifungals?¶
Authors: Szvalb AD et al. | Journal: Clin Infect Dis | Date: 2026 Jun 29
DOI: 10.1093/cid/ciag393
TL;DR: culture-positive invasive aspergillosis 的可歸因死亡率十年間下降,但 contributable 與全因死亡率仍高;僅改善 antifungals 恐已達效益上限,尚須增強宿主免疫。
不嘻嘻:antifungals 已摸到天花板,免疫力還在樓下按電鈴。
Tuberculosis in pregnancy: Challenges of immune protection¶
Authors: Yengkhom D et al. | Journal: J Infect Dis | Date: 2026 Jun 29
DOI: 10.1093/infdis/jiag345
TL;DR: 懷孕與 HIV 會改變對 M. tuberculosis 的免疫反應並增加 TB 風險;目前孕婦的治療及預防證據仍不足,合併 HIV 者尤其缺乏最佳策略。
不嘻嘻:孕婦加上 HIV,TB 指引立刻變成大片留白。
Metagenomic next-generation sequencing of cerebrospinal fluid reveals pathogen spectrum and mortality predictors among patients with advanced HIV-1 disease at a tertiary hospital in China¶
Authors: Wan LY et al. | Journal: Virol J | Date: 2026 Jun 29
DOI: 10.1186/s12985-026-03234-x
TL;DR: 中國廣西61名未治療 advanced HIV-1 患者的 CSF mNGS 共檢出206個病原,以 EBV、CMV 最多;血漿 LDL 與 CSF LDH 為院內死亡獨立預測因子。
嘻嘻:CSF mNGS 很會抓鬼,但抓到的不一定都是兇手。
Cryptococcus gattii complex infections in southern Brazil: epidemiology, clinical features, management and outcomes from a 33-year cohort¶
Authors: Carneiro BH et al. | Journal: Med Mycol | Date: 2026 Jun 30
DOI: 10.1093/mmy/myag068
TL;DR: 巴西南部39例 C. gattii complex 感染中,76.9%有肺病、69.2%有腦膜炎,死亡率20.5%;重度意識障礙與 CSF protein >92.15 mg/dL 預測死亡。
不嘻嘻:C. gattii 一住就是肺腦雙套房,退租還很困難。
Breaking barriers: Implementation of a tuberculosis preventive treatment protocol among newly eligible populations with promising results¶
Authors: Gijón P et al. | Journal: Eur J Clin Microbiol Infect Dis | Date: 2026 Jun 30
DOI: 10.1007/s10096-026-05570-w
TL;DR: 554名 TPT 對象中97.8%開始治療,完成率86.5%;cancer 預測未完成(aOR 2.25),polypharmacy 與 inflammatory disease 各自預測毒性導致中止。
嘻嘻:TPT 真能落地完成,這種執行力比新藥更稀有。
Human cytomegalovirus (HHV5) reactivation during lactation¶
Authors: Dolata N et al. | Journal: Microb Pathog | Date: 2026 Jun 29
DOI: 10.1016/j.micpath.2026.108665
TL;DR: 乳汁中高濃度 HCMV 可傳給新生兒,低出生體重與極早產兒風險最高;pasteurization 可降低風險,而病毒 latency、免疫逃脫及 reactivation 由多重病毒與宿主因子調控。
不嘻嘻:HCMV 趁哺乳重出江湖,早產兒又得先承擔風險。
Cytomegalovirus Interstitial Pneumonia: A Plague of Marrow Transplant That the Field Solved¶
Authors: Forman SJ | Journal: Transplant Cell Ther | Date: 2026 Jul
DOI: 10.1016/j.jtct.2026.06.011
TL;DR: 回顧異體移植早期CMV間質性肺炎曾是無藥可治的絕症,直到preemptive ganciclovir監測策略與CMV專一性T細胞免疫重建問世才逐漸解決,紀念病毒學先驅Zaia與Myers。
嘻嘻:曾經必死的絕症被preemptive監測和幾位固執前輩聯手打敗,經典勝利。
Reduced-dose post-transplant cyclophosphamide as graft-versus-host disease prophylaxis in matched donor allogeneic stem cell transplantation: a systematic review of efficacy and toxicity¶
Authors: Shafqat A et al. | Journal: Transplant Cell Ther | Date: 2026 Jun 29
DOI: 10.1016/j.jtct.2026.06.038
TL;DR: 18項研究顯示40–90 mg/kg PTCy 的 GVHD 與存活結果大致不劣於標準劑量,且 CMV reactivation、出血性膀胱炎較少、engraftment 較快,但偏差風險高。
嘻嘻:PTCy 少給一點或許更剛好,但證據還得補強。
Population Pharmacokinetic Modelling of Dolutegravir: A Narrative Review¶
Authors: Pilote É et al. | Journal: Clin Pharmacokinet | Date: 2026 Jun 30
DOI: 10.1007/s40262-026-01653-1
TL;DR: 23項 PopPK 研究顯示,校正體型後 dolutegravir 的 CL/F 與 Vd/F 跨族群相近,現行建議劑量多可達標;早產兒、孕婦、肥胖及高齡者資料仍不足。
嘻嘻:dolutegravir 相當可靠,特殊族群仍需要專屬資料。
VICTOR-CPA: Oral itraconazole versus oral voriconazole for treatment-naive patients with chronic pulmonary aspergillosis in India¶
Authors: Mehta AA | Journal: Lung India | Date: 2026 Jul 01
DOI: 10.4103/lungindia.lungindia_800_25
TL;DR: 評論印度VICTOR-CPA單中心RCT:初治chronic pulmonary aspergillosis病人以itraconazole對比voriconazole,voriconazole組肝毒性與皮膚黏膜毒性較高;呼籲建立CPA專屬多面向預後工具並擴大多中心研究。
嘻嘻:itraconazole打敗voriconazole副作用榜,CPA治療總算有個相對安全的答案。
Recombinant listeriolysin-O as a platform for next-generation vaccines: Mechanisms, immunological evidence, and translational applications in human and veterinary medicine¶
Authors: Shihab TJ et al. | Journal: Open Vet J | Date: 2026 Mar
DOI: 10.5455/OVJ.2026.v16.i3.1
TL;DR: rLLO 可促進 cytosolic antigen delivery、cross-presentation 與 CD8⁺ T-cell 活化,具疫苗佐劑潛力;但臨床轉譯前仍須釐清毒性、劑量、給藥及法規要求。
嘻嘻:rLLO 很會送 antigen,離臨床只差一長串安全考題。
Augmentation of IL-21 and soluble CD14 in systemic aspergillosis through combined immunostimulation with beta-glucan and diphtheria toxoid¶
Authors: Hameed MAK et al. | Journal: Open Vet J | Date: 2026 Apr
DOI: 10.5455/OVJ.2026.v16.i4.7
TL;DR: 50隻大鼠的 systemic A. fumigatus 模型中,beta-glucan 合併 diphtheria toxoid 使 IL-21 與 sCD14 增幅最大,顯示可同時刺激 adaptive 與 innate immunity。
嘻嘻:免疫雙重助攻頗亮眼,先等它通過人體這一關。
Role of the Fungal Serological Marker Galactomannan Antigen in the Diagnosis of Invasive Fungal Infection: A Three-Year Retrospective Study¶
Authors: Mohapatra S et al. | Journal: Cureus | Date: 2026 May
DOI: 10.7759/cureus.109923
TL;DR: 印度172名疑似 IFI 患者中,serum galactomannan 診斷 invasive aspergillosis 的 sensitivity 82.4%、specificity 46.8%,AUC 0.69,較適合作為輔助而非單獨確診工具。
不嘻嘻:galactomannan 適合當線索,硬當法官就容易誤判。
Safety profile of upadacitinib in inflammatory Bowel disease: a dual-source pharmacovigilance study integrating FAERS signal detection and real-world clinical cohort analysis¶
Authors: Tan W et al. | Journal: Front Pharmacol | Date: 2026
DOI: 10.3389/fphar.2026.1830935
TL;DR: 183名 IBD 患者使用 upadacitinib 後46.4%出現 AE,38.8%於30日內、67.0%於60日內發生;FAERS 另偵測到 PJP、herpes zoster 及 venous thrombosis signals。
不嘻嘻:upadacitinib 出手很快,AE 報到也沒遲到。
Hylocereus undatus flower inhibits lipopolysaccharide-induced acute lung injury in mice by regulating the gut-lung axis and inflammatory response¶
Authors: Fu S et al. | Journal: Front Pharmacol | Date: 2026
DOI: 10.3389/fphar.2026.1803336
TL;DR: 小鼠 lipopolysaccharide-induced acute lung injury 模型中,H. undatus flower extract 減輕肺水腫與發炎,並透過 gut microbiota、SCFAs 及 P38 MAPK pathway 改善肺損傷。
嘻嘻:霸王花連 gut-lung axis 都管,但小鼠先別急著封神。
Risk factors and treatment outcomes of drug-resistant tuberculosis among patients attending Ndola Teaching Hospital, Zambia: a retrospective case-control study¶
Authors: Mckees R et al. | Journal: Pan Afr Med J | Date: 2026
DOI: 10.11604/pamj.2026.53.84.50004
TL;DR: 尚比亞110例 MDR-TB 與110名對照中,治療成功率73.6%;接觸 TB 患者增加 MDR-TB 風險(aOR 1.67),但多項迴歸結果與 CI、P值不一致,宜審慎解讀。
不嘻嘻:MDR-TB 已夠難,統計資料還自己互相拆台。
Current perspectives on avian tuberculosis in domestic and wild birds: Molecular diagnostics, genomic surveillance, and vaccination challenges¶
Authors: Puspitasari Y et al. | Journal: Open Vet J | Date: 2026 May
DOI: 10.5455/OVJ.2026.v16.i5.1
TL;DR: avian tuberculosis 主要由 Mycobacterium avium subsp. avium 引起,對免疫低下者具 zoonotic risk;診斷須整合 culture、histopathology、molecular methods,防治仍以 biosecurity 為主。
不嘻嘻:禽鳥 TB 防線仍靠 biosecurity,老派但暫時沒得選。
A 9-year retrospective mortality review of captive orange-bellied parrots (Neophema chrysogaster) in Australia¶
Authors: Bayley CL et al. | Journal: Aust Vet J | Date: 2026 Jun 29
DOI: 10.1111/avj.70092
TL;DR: 澳洲圈養 orange-bellied parrots 九年死亡回顧中,感染占35%,以呼吸道 aspergillosis 等為主;46%無法確定死因,histology 可提高幼鳥診斷成功率。
不嘻嘻:鸚鵡死因近半成謎,病理醫師只能繼續解鎖答案。
Pneumocystis pneumonia in non-HIV immunocompromised patients in 2026: evolving therapeutic standards¶
Authors: Kemp H et al. | Journal: Expert Rev Anti Infect Ther | Date: 2026 Jun 29
DOI: 10.1080/14787210.2026.2695974
TL;DR: 非 HIV 免疫低下者的 PJP 發生率上升,且比 HIV 患者更易重症與死亡;急性呼吸衰竭時應高度懷疑並於確診前及早治療,qPCR threshold 仍待標準化。
不嘻嘻:非 HIV 的 PJP 更兇,診斷門檻卻還各說各話。
Extranodal natural killer/T-cell lymphoma: From fatal to curable¶
Authors: Xiong J et al. | Journal: CA Cancer J Clin | Date: 2026
DOI: 10.3322/caac.70094
TL;DR: 現今近80%新診斷 ENKTCL 患者可長期存活;早期以 combined-modality therapy、晚期以 immune 與 metabolic targets 為主,EBV-directed therapies 正持續開發。
嘻嘻:ENKTCL 從致命走向可治,這次進步真的有感。
🟢 One Health / Zoonoses¶
From Norovirus to Andes Hantavirus: Indirect Viral Transmission and Emerging Prevention Strategies for Cruise Ship and Confined Environments¶
Authors: Urmi UL et al. | Journal: Rev Med Virol | Date: 2026 Jul
DOI: 10.1002/rmv.70180
TL;DR: 2025–2026年郵輪 norovirus 與 Andes hantavirus outbreak 顯示,清潔、隔離及 contact tracing 仍不足;air decontamination 與 antiviral surfaces 可望補強被動防護。
不嘻嘻:郵輪病毒很懂社交,傳統防疫只好繼續追船跑。
Exosome-enriched extracellular vesicles are associated with Getah virus RNA and transmission-related readouts in vitro¶
Authors: Liu Y et al. | Journal: Front Cell Infect Microbiol | Date: 2026
DOI: 10.3389/fcimb.2026.1838901
TL;DR: GETV-infected 細胞的 exosome-enriched EV 含受膜保護的全基因體 RNA,受體細胞攝入後病毒 RNA 與 protein 增加;但 EV 與 virion 尚未完全分離,傳遞機制仍待確認。
嘻嘻:EV 可能暗送病毒包裹,但得先排除 virion 冒名。
Clonal diversity, virulence factors and antibiotic resistance genes of Enterococcus faecalis and Klebsiella pneumoniae from urban rats in Malaysia¶
Authors: Yap PC et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101489
TL;DR: 馬來西亞277隻都市鼠分離出19株 E. faecalis 與7株 K. pneumoniae,發現7個新 ST;多株帶 virulence 或 resistance genes,支持納入 One Health surveillance。
不嘻嘻:都市鼠攜帶的基因配備,比我們想像得更豪華。
Global surveillance of anthrax outbreaks in domestic animals and humans: A retrospective secondary analysis of reported cases over two decades (2005-2024)¶
Authors: Ala IU et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101460
TL;DR: 2005–2024年全球 anthrax 通報整體下降,但中亞、非洲及南亞仍持續 endemic,土耳其家畜病例未減、另有6國上升;WAHIS 與 ProMED 差異反映 surveillance 缺口。
不嘻嘻:anthrax 沒消失,只是監測系統彼此看見不同世界。
Variability in the regulation of medically important antimicrobials among countries: A One Health approach¶
Authors: Okunola A et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101473
TL;DR: 整合人醫與獸醫重要性分類後,53% antimicrobial 配對屬 H3V1;至少半數國家的 One Health Score 非負,但21%國家對 H3V1 的 MRL 比 Codex 寬鬆。
不嘻嘻:One Health 喊得整齊,antimicrobial 規範仍各吹各調。
Toward a decolonial One Health: Findings from a participatory action research initiative with indigenous, Campesino, and Afro-descendant communities in the Amazon¶
Authors: Méndez-Paz F et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101476
TL;DR: 2021–2024年於哥倫比亞、厄瓜多及祕魯亞馬遜社群的 participatory action research 顯示,共同研究、跨文化對話與領土自主可產生更切合在地且永續的 One Health 解方。
嘻嘻:讓在地社群主導問題,One Health 才不只是外來劇本。
Spatiotemporal distribution trends and driving factors of avian influenza in poultry in China¶
Authors: Li F et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101483
TL;DR: 中國家禽 avian influenza 高峰為11月至3月,熱點在東南部,H9N2 病例最多;XGBoost 顯示道路、人口、GDP 與家禽交易等人類活動為首要驅動因子。
不嘻嘻:avian influenza 追著人類活動跑,病毒也懂交通經濟學。
Global genomic surveillance of Salmonella in the environment: assessing virulence and antimicrobial resistance at scale¶
Authors: Bandsode V et al. | Journal: mBio | Date: 2026 Jun 22
DOI: 10.1128/mbio.01142-26
TL;DR: 1,399株環境 Salmonella genome 分析中,印度分離株55.6%為 MDR、72.2%具強 biofilm;並檢出 mcr-1、mcr-5、mcr-9,顯示環境可作 AMR early-warning reservoir。
不嘻嘻:河川成了 AMR 展示櫃,連 colistin 防線都被擺上架。
Maintenance of Hokkaido virus, a genotype of Orthohantavirus puumalaense, in the rodent host Myodes rufocanus bedfordiae under natural conditions¶
Authors: Duong TNT et al. | Journal: J Virol | Date: 2026 Jun 30
DOI: 10.1128/jvi.00321-26
TL;DR: 日本北海道199隻野生鼠中23隻帶 HOKV,18隻屬 persistent infection;infectious virus 可自口腔8/8、尿液3/6及糞便4/6檢出,支持多途徑長期排毒。
不嘻嘻:HOKV 長住又多路排出,野鼠堪稱全方位散播者。
The potential role of Escherichia coli as an indicator of environmental antimicrobial resistance in an urban river in Japan¶
Authors: Matsui K et al. | Journal: Sci Rep | Date: 2026 Jun 28
DOI: 10.1038/s41598-026-56659-3
TL;DR: 日本大阪都市河川在可能發生 CSO 的豪雨後15小時,coliform 與 E. coli 增逾100倍;E. coli 的 ampicillin resistance 平均23.1%,可兼作糞便污染與環境 AMR 指標。
不嘻嘻:一場豪雨就沖出 AMR 實況,都市河川毫不演戲。
A whole genome-based characterization of Listeria monocytogenes strains isolated from invasive infections in Northwest Italy, 2022-2025¶
Authors: Monica P et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1867228
TL;DR: 義大利西北部135株侵襲性 L. monocytogenes 共分36個 ST、29個 CC,以 CC1占20.7%最多;hypervirulent Lineage I 與跨國 cluster 相關 ST155 均持續流行。
不嘻嘻:hypervirulent L. monocytogenes 持續巡演,邊界形同虛設。
Aeromonas salmonicida isolated from pigs: Genomic and phenotypic antimicrobial resistance characterization¶
Authors: Xu N et al. | Journal: Open Vet J | Date: 2025 Dec
DOI: 10.5455/OVJ.2025.v15.i12.57
TL;DR: 中國吉林786隻病豬分離13株 A. salmonicida,全數對多種 β-lactams 與 sulfonamides resistant,並帶 mcr-3.16、cphA5、bla OXA-956 等 mobile resistance genes。
不嘻嘻:豬源 A. salmonicida 帶著 mobile genes,藥櫃又少幾格。
Efficacy of a multivalent inactivated Salmonella vaccine against fecal shedding and organ dissemination in chickens¶
Authors: Elfeil WK et al. | Journal: Open Vet J | Date: 2025 Dec
DOI: 10.5455/OVJ.2025.v15.i12.55
TL;DR: 250隻雞試驗中,四價不活化 Salmonella vaccine 無明顯 AE,顯著提高 antibody、降低 challenge 後14日 fecal shedding,且第4日起肝臟直接培養已無可檢出菌。
嘻嘻:四價 vaccine 能壓低排菌,雞場 biosecurity 終於有隊友。
Bacterial diversity in certain captive snake species in Bulgaria: A One Health challenge - pilot study¶
Authors: Boneva-Marutsova B | Journal: Open Vet J | Date: 2026 Apr
DOI: 10.5455/OVJ.2026.v16.i4.5
TL;DR: 保加利亞29份圈養蛇樣本中,8份分離出 Salmonella enterica group B,另見多種 zoonotic bacteria;寵物蛇、飼料與受污染環境可能構成人畜傳播鏈。
不嘻嘻:寵物蛇自帶 zoonotic bacteria,飼主驚喜包請勿拆封。
🟡 Food Security / Food Safety¶
An electrochemical sensor for ultrasensitive and wide-range detection of the food additive potassium ferrocyanide based on signal attenuation mechanism of a poly(caffeic acid) film¶
Authors: Wu S et al. | Journal: Food Chem | Date: 2026 Jun 27
DOI: 10.1016/j.foodchem.2026.150213
TL;DR: poly(caffeic acid) electrochemical sensor 可於5分鐘內偵測 potassium ferrocyanide,LOD 6.3×10⁻¹³ M;食品樣本 recovery 為85.07%–108.43%。
嘻嘻:五分鐘完成超靈敏偵測,食品篩檢又多一把快刀。
A framework for reporting texture profile analysis in cultivated meat research¶
Authors: Millbank A et al. | Journal: Food Chem | Date: 2026 Jun 19
DOI: 10.1016/j.foodchem.2026.150134
TL;DR: 41項 cultivated meat TPA 研究的樣本尺寸、測試參數與烹調流程差異甚大;BIOPLATE checklist 提供標準化報告架構,以改善透明度及跨研究比較。
嘻嘻:BIOPLATE 先統一量尺,cultivated meat 才能公平比口感。
Toward safer plant-based foods: Fluorometric identification of red 3 in bacon alternatives¶
Authors: Moi DK et al. | Journal: Food Chem | Date: 2026 Jun 27
DOI: 10.1016/j.foodchem.2026.150222
TL;DR: 新 fluorometric method 以 methanol sonication 偵測 Red 3,553 nm emission 下可達 ppb 級 LOD/LOQ;全流程30分鐘、每份樣本使用25 mL solvent,適合大量篩檢。
嘻嘻:Red 3 半小時現形,替 plant-based food 補上快篩。
Simultaneous enantioselective determination of six non-steroidal anti-inflammatory drug enantiomers in multi-specie meat products with novel chiral LC-MS/MS method¶
Authors: Xu X et al. | Journal: Food Chem | Date: 2026 Jun 27
DOI: 10.1016/j.foodchem.2026.150221
TL;DR: 新 chiral LC-MS/MS 可同時測定牛羊肉中6種 NSAID enantiomers,r²≥0.9990、recovery 91.7%–104.3%、precision RSD≤6.2%,LOD 0.30–1.42 ng/g。
嘻嘻:enantiomers 一次分清,肉品 NSAID 監測更精準了。
Germination-driven biochemical remodeling of cereals and pseudocereals: Impacts on nutrient bioaccessibility, phytochemical enrichment, and functional food potential¶
Authors: Benabdelmoumene D et al. | Journal: Food Chem | Date: 2026 Jun 28
DOI: 10.1016/j.foodchem.2026.150232
TL;DR: germination 可降低 phytic acid 等 antinutrients,並增加 GABA、phenolics、vitamins 與 bioactive peptides,改善穀類消化性及營養 bioaccessibility,但安全與接受度仍須評估。
嘻嘻:發芽讓穀物營養升級,但安全與風味仍要過消費者關。
Plasmonic graphene oxide aptasensor empowered for ultra‑sensitive and rapid detection of aflatoxin M1 in dairy product¶
Authors: Mardanqom HN et al. | Journal: Sci Rep | Date: 2026 Jun 29
DOI: 10.1038/s41598-026-60164-y
TL;DR: graphene oxide-chitosan SPR aptasensor 對乳品 AFM1 的 LOD 為0.005 ng/mL、linear range 0.005–50 ng/mL,並經 HPLC 比對顯示具高 sensitivity 與 selectivity。
嘻嘻:AFM1 微量也難逃 aptasensor,乳品把關更有底氣。
Digital orientation enables disruptive technological innovation in agricultural technology enterprises¶
Authors: Chen Y et al. | Journal: Sci Rep | Date: 2026 Jun 29
DOI: 10.1038/s41598-026-59336-7
TL;DR: 中國422家農業科技企業調查顯示,digital orientation 可直接及透過 sensing、seizing、reconfiguring capabilities 促進 disruptive innovation,並受 unlearning 與 resource orchestration 強化。
嘻嘻:數位思維能推動創新,但問卷裡成功總是比較容易。
Socioecological Factors Interact to Drive Differences in Hygiene Indicator Load on Retail Fresh Produce Available to Athens, GA Communities¶
Authors: Cullinan S et al. | Journal: J Food Prot | Date: 2026 Jun 29
DOI: 10.1016/j.jfp.2026.100848
TL;DR: 美國雅典市兩社區共檢驗432份蔬果,未檢出 S. enterica,E. coli 皆低於可計數範圍;coliform load 則受季節、商店類型及社區交互作用顯著影響。
嘻嘻:生鮮蔬果沒抓到主要病原,至少這輪可以安心一點。
Barriers to Nutrition Security in the US¶
Authors: Owens CE et al. | Journal: JAMA Netw Open | Date: 2026 Jun 01
DOI: 10.1001/jamanetworkopen.2026.20264
TL;DR: 美國3,000名成人中,nutrition insecurity 者平均有7.8項飲食障礙,security 者為4.4項;每增加一項障礙,diabetes、heart disease 或 obesity 的 odds 約增9%–16%。
不嘻嘻:飲食障礙層層疊加,慢性病當然也來湊熱鬧。
Time-series dynamics and biocontrol potential of postharvest bacteria in litchi microbiota¶
Authors: Hou H et al. | Journal: Sci China Life Sci | Date: 2026 Jun 25
DOI: 10.1007/s11427-025-3302-x
TL;DR: 兩種荔枝9日儲存期間有5個 bacterial genera 可追蹤鮮度,random forest 預測 R²>0.9;Gluconobacter sp. Lc45 對兩種採後 fungal pathogens 呈強 antagonism。
嘻嘻:細菌既能報鮮度又能抗真菌,荔枝找到微生物保鑣。
Functional and Genomic Features of a Lytic Salmonella Phage vB_StyS_KFSST1 for Development as New Feed Additive¶
Authors: Kim SH et al. | Journal: Food Sci Anim Resour | Date: 2025 Jul
DOI: 10.5851/kosfa.2025.e34
TL;DR: lytic phage vB_StyS_KFSST1 可裂解 S. Enteritidis 與 S. Typhimurium,抑制長達12小時;47,149-bp genome 未見 lysogeny、AMR 或 virulence genes。
嘻嘻:phage 能打兩種 Salmonella,基因履歷也相當乾淨。
Enhancing Prosciutto through Cold Plasma: From Pathogen Inactivation to Quality Retention¶
Authors: Lee J et al. | Journal: Food Sci Anim Resour | Date: 2025 Sep
DOI: 10.5851/kosfa.2024.e98
TL;DR: prosciutto 經 cold plasma 處理5分鐘可使5種 foodborne bacteria 約下降2-log CFU,hepatitis E virus RNA 於9分鐘後不可檢出,且硬度與 water activity 無顯著改變。
嘻嘻:cold plasma 殺病原又留品質,火腿終於能兩全其美。
Occurrence and antimicrobial susceptibility patterns of Escherichia coli and Salmonella species in raw beef from abattoir and retailer shops in Nairobi, Kenya¶
Authors: Kasiwai CC et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1808597
TL;DR: 肯亞奈洛比106份生牛肉分離的50株 E. coli 與17株疑似 Salmonella 均對 ampicillin/cloxacillin resistant,且全數至少帶2個 resistance genes,包括 bla TEM、bla CMY-2。
不嘻嘻:生牛肉的 resistance genes 集體報到,烤熟只是基本禮貌。
Prevalence, virulence attributes, and antimicrobial resistance profiling of Staphylococcus aureus and Salmonella spp., isolated from camel meat and offal¶
Authors: Khairy AA et al. | Journal: Open Vet J | Date: 2025 Dec
DOI: 10.5455/OVJ.2025.v15.i12.62
TL;DR: 90份駱駝肉與內臟中,S. aureus prevalence 最高達100%,Salmonella 為27.8%;前者 kanamycin resistance 100%,後者 nalidixic acid resistance 100%。
不嘻嘻:駱駝肉病原與抗藥性雙滿載,餐桌風險毫不低調。
Antibiotic resistance of Escherichia coli isolated from pigeon fecal samples in Bac Ninh, Vietnam¶
Authors: Huong CTT et al. | Journal: Open Vet J | Date: 2026 May
DOI: 10.5455/OVJ.2026.v16.i5.44
TL;DR: 越南北寧128份鴿糞中97份(75.8%)檢出 E. coli,68.0%為 MDR;ampicillin resistance 69.1%,且所有 quinolone-resistant isolates 至少帶1個 PMQR gene。
不嘻嘻:鴿糞裡 MDR E. coli 很普遍,城市天空也有抗藥性陰影。
資料來源:PubMed (articles retrieved 2026-07-01)