Daily Journal Digest — 2026-06-16¶
過去 24 小時新增：Transplant ID × 30、One Health × 13、Food Security × 14，共 57 篇。
⭐ 今日亮點¶
- Improved Tolerability of De Novo Letermovir Over Valganciclovir for Cytomegalovirus Prophylaxis in Seropositive Liver Transplant Recipients
肝移植CMV預防可立即轉化 - Diagnostic Performance and Clinical Impact of Metagenomic Next-Generation Sequencing in 841 Patients with Suspected Lower Respiratory Tract Infections: A Four-Year Retrospective Study from a Tertiary Hospital in Shenzhen, China
大規模BALF mNGS真實世界效益 - Free-ranging hedgehogs as sentinels of environmental extended-spectrum β-lactamase-producing Enterobacterales
One Health AMR哨兵訊號清楚
🔬 深入評讀¶
Improved Tolerability of De Novo Letermovir Over Valganciclovir for Cytomegalovirus Prophylaxis in Seropositive Liver Transplant Recipients¶
Clin Transplant | IF 2.0 | DOI
- 設計：這是2021/6/1至2024/9/30成人CMV R+ liver transplant的回溯性世代研究，比較de novo letermovir與valganciclovir預防。主要問題不是證明letermovir優於標準治療，而是看1年內耐受性、安全性與臨床可行性。
- 樣本：共85名受試者，valganciclovir組60人、letermovir組25人；追蹤至移植後1年，並比較3個月與6個月mycophenolate總日劑量。兩組人數不大且比例約2.4:1，特別是letermovir組只有25人，估計值會受單中心用藥選擇影響。
- 關鍵數字：letermovir完成預防比例較高，92.0% vs 68.3%（p=0.02），valganciclovir組轉換策略中位時間為移植後58天，這是臨床上有感的差距。letermovir組leukopenia較少（52.0% vs 81.7%, p=0.005）、neutropenia較少（24.0% vs 50.0%, p=0.03）、GCSF需求較少（4.0% vs 25.0%, p=0.024），效應量不小且方向一致；1年CMV viremia與acute rejection無顯著差異，但樣本數不足以排除中等幅度差異。
- Limitation：主要限制是回溯性、非隨機分派與單中心處方偏差，letermovir被選用的25人可能本來就有不同的骨髓抑制風險或免疫抑制策略。CMV viremia、acute rejection與mycophenolate劑量之間也有confounding by indication，且研究未能以85人可靠評估罕見但關鍵的ganciclovir-resistant CMV或長期graft outcome。
- Bottom line：對CMV R+ liver transplant，de novo letermovir在1年資料中看起來可減少骨髓抑制並提高預防完成率，但目前更像是高風險耐受性策略，而非已取代valganciclovir的定論。
Diagnostic Performance and Clinical Impact of Metagenomic Next-Generation Sequencing in 841 Patients with Suspected Lower Respiratory Tract Infections: A Four-Year Retrospective Study from a Tertiary Hospital in Shenzhen, China¶
Int J Infect Dis | IF 3.1 | DOI
- 設計：這是深圳單一三級醫院2021/12至2025/12的4年回溯性研究，納入疑似lower respiratory tract infections且同時做BALF mNGS與conventional culture者。設計重點放在檢出率、polymicrobial identification、年齡與共病分層病原分布，以及mNGS-only結果對診斷與抗微生物治療的臨床影響。
- 樣本：共841名住院病人，所有人都有BALF paired testing，因此比較基礎比許多只看mNGS陽性個案的研究更完整。追蹤時間以臨床處置影響為主，摘要未提供固定30天或90天outcome，也未列出各組免疫低下者人數。
- 關鍵數字：mNGS的整體與polymicrobial detection均顯著高於culture，且超過50%的病原只由mNGS檢出，其中又有超過50%影響診斷或抗微生物治療，代表效益不只是實驗室陽性率增加。特別值得注意的是Mycobacterium tuberculosis complex、nontuberculous mycobacteria、Cryptococcus neoformans與Pneumocystis jirovecii即使read counts低仍有臨床意義，這對免疫低下與難治肺炎判讀很實用。
- Limitation：這類研究最大的限制是retrospective clinical impact判定容易有reviewer與documentation bias，且mNGS陽性不等於感染，colonization、污染與死菌DNA都會放大檢出率。以culture作比較也不等於完整reference standard，若沒有獨立adjudication、抗菌藥暴露分層與一致的BALF採樣時機，841人的規模仍不能直接換算成診斷準確度或存活效益。
- Bottom line：BALF mNGS在疑似LRTI特別是混合感染、抗生素失敗、TB/NTM、Cryptococcus與PJP情境有實際加值，但報告必須和宿主風險、影像、定量訊號與傳統微生物結果一起判讀。
Free-ranging hedgehogs as sentinels of environmental extended-spectrum β-lactamase-producing Enterobacterales¶
One Health | IF 5.7 | DOI
- 設計：這是以色列全國性free-ranging hedgehogs糞便帶菌監測，研究ESBL-producing Enterobacterales與carbapenem-resistant Enterobacterales在都市周邊野生動物的分布。設計把野生動物放在human-animal-environment介面，適合作為One Health AMR surveillance的補充框架。
- 樣本：2022/12至2023/9共246隻hedgehogs，來源為全國救援後送至唯一wildlife hospital，入院時採檢並對所有分離株做antimicrobial susceptibility testing。追蹤是橫斷面入院採樣，沒有個體長期追蹤或環境、人類、寵物同步採樣。
- 關鍵數字：ESBL-PE帶菌率高達71%，CRE為2%，以E. coli為主，其次為Citrobacter、Klebsiella與Enterobacter spp.；quinolone resistance達83%、trimethoprim-sulfamethoxazole resistance達46%，這不是零星污染，而是高壓力AMR背景的生態訊號。帶菌率在假期與戶外活動增加月份較高，雖然只是時間相關，但提示人類活動可能改變野生動物暴露。
- Limitation：最大限制是selection bias，246隻都是被救援且送醫的hedgehogs，不能直接代表所有野外族群。研究摘要未顯示WGS、plasmid typing或與人類臨床株的基因體比對，因此71%高盛行率能證明哨兵價值，但尚不能證明傳播方向或來源。
- Bottom line：都市共棲野生動物可成為AMR環境壓力的早期哨兵；若下一步加入人類、污水、寵物與基因體監測，hedgehog surveillance可能補上傳統臨床AMR監測看不到的一塊。
🔴 Transplant & Opportunistic Infections¶
Central Nervous System T-cell immune architecture, and not HIV burden, tracks with cognition under long-term viral suppression¶
Authors: Trunfio M et al. | Journal: PLoS Pathog | Date: 2026 Jun 15
DOI: 10.1371/journal.ppat.1014351
TL;DR: 12名長期viral suppression的HIV患者rapid autopsy顯示，CNS TCR richness/diversity與較差認知相關，HIV DNA/RNA負荷則無關。
不嘻嘻：HIV安靜了，腦內免疫戲還沒散場。
Amplified inflammatory and immune responses in viral-associated pulmonary aspergillosis¶
Authors: Li X et al. | Journal: Front Cell Infect Microbiol | Date: 2026
DOI: 10.3389/fcimb.2026.1850127
TL;DR: 55名viral pneumonia患者中，VAPA組20人呈更強systemic inflammatory activity、免疫失調、肝腎損傷與凝血異常，multi-omics支持早期辨識。
不嘻嘻：VAPA一來，全身發炎像加開夜診。
Clinical characteristics of Pneumocystis jirovecii pneumonia in non-HIV patients: a retrospective study¶
Authors: Li M et al. | Journal: Front Cell Infect Microbiol | Date: 2026
DOI: 10.3389/fcimb.2026.1710074
TL;DR: 39名非HIV PJP患者中，重症組病死率61.1%對0%；LDH升高（OR 1.863）與CMV coinfection（OR 11.477）獨立預測重症。
不嘻嘻：非HIV PJP重起來，ICU又要嘆氣。
The complexity of invasive fungal diseases in the intensive care unit: evaluation of metagenomic next-generation sequencing¶
Authors: Wang R et al. | Journal: Front Cell Infect Microbiol | Date: 2026
DOI: 10.3389/fcimb.2026.1820501
TL;DR: 106名ICU invasive fungal infections患者中66.26%為immunocompetent；mNGS檢出74個病原、CMT 44個，並改變70.75%臨床處置。
嘻嘻：ICU真菌戰場，mNGS總算像開燈找人。
Animal models of fungus-related allergic airway disease: exposures, readouts, mechanisms, and translational gaps¶
Authors: Qu Y et al. | Journal: Front Cell Infect Microbiol | Date: 2026
DOI: 10.3389/fcimb.2026.1856761
TL;DR: AFAD動物模型各有侷限；Aspergillus fumigatus或Alternaria alternata spores較能模擬人類混合eosinophilic/neutrophilic airway disease。
不嘻嘻：模型再像人，也還是差臨床一口氣。
Metagenomic next-generation sequencing reveals microbial community characteristics during acute exacerbations of interstitial pneumonia and their associations with clinical phenotypes¶
Authors: Ma M et al. | Journal: Front Cell Infect Microbiol | Date: 2026
DOI: 10.3389/fcimb.2026.1809022
TL;DR: ILD急性惡化時mNGS敏感度95.60%高於CMT 32.20%；microbial diversity下降，Candida albicans與Abiotrophia defectiva較富集。
嘻嘻：ILD急惡化的病原黑箱，mNGS有戲。
Iron starvation confers azole tolerance in Aspergillus fumigatus hyphae via mitochondrial function modulation¶
Authors: Cong L et al. | Journal: mBio | Date: 2026 Jun 15
DOI: 10.1128/mbio.00896-26
TL;DR: iron starvation降低Aspergillus fumigatus MIC卻延長hyphae azole MDK99；coenzyme Q10可恢復azole fungicidal activity。
不嘻嘻：A. fumigatus餓鐵也能撐azole，真會過日子。
An epigenetic mechanism of azole tolerance facilitates acquired antifungal resistance in Aspergillus fumigatus¶
Authors: Vellanki S et al. | Journal: mBio | Date: 2026 Jun 15
DOI: 10.1128/mbio.00661-26
TL;DR: Aspergillus fumigatus失去IngB造成azole tolerance，murine voriconazole治療下肺部fungal burden較高，並加速umpA相關azole resistance。
不嘻嘻：A. fumigatus連表觀遺傳都拿來抗藥。
Mapping the monoclonal antibody landscape of human cytomegalovirus¶
Authors: McClave MK et al. | Journal: J Virol | Date: 2026 Jun 15
DOI: 10.1128/jvi.00325-26
TL;DR: HCMV mAbs綜述彙整1980年代至今target antigens、epitopes與neutralizing activity，指出結構與功能資料可引導治療與預防開發。
嘻嘻：HCMV mAbs地圖越清楚，武器庫越像樣。
An interpretable radiomics-machine learning model for early risk stratification of invasive fungal infections in community-acquired pneumonia: a dual-center study¶
Authors: He W et al. | Journal: Sci Rep | Date: 2026 Jun 14
DOI: 10.1038/s41598-026-56091-7
TL;DR: 570名CAP患者dual-center資料中，HRCT radiomics加clinical model預測IFI最佳，external validation AUC 0.786，高於單用clinical或radiomics。
嘻嘻：CAP影像多一層算盤，IFI可望早點抓。
Cellular and molecular responses of Cryptococcus to brilacidin¶
Authors: Bezerra BT et al. | Journal: Microbiol Spectr | Date: 2026 Jun 15
DOI: 10.1128/spectrum.00138-26
TL;DR: brilacidin對Cryptococcus MIC 2.5 µM，低cytotoxicity，並使amphotericin B有效劑量最高降8倍，破壞capsule與biofilm。
嘻嘻：brilacidin打Cryptococcus，還幫amphotericin B省力。
Clinical spectrum of extrapulmonary tuberculosis at a tertiary care centre in Ghana: a retrospective study¶
Authors: Appati W et al. | Journal: BMC Infect Dis | Date: 2026 Jun 13
DOI: 10.1186/s12879-026-13810-9
TL;DR: 迦納1,098名TB患者中isolated EPTB占16.3%；spinal TB 40.8%最常見，35–54歲與spinal TB相關（aOR 3.2）。
不嘻嘻：EPTB位置百百種，診斷耐心先備好。
Pulmonary tuberculosis mimicking cystic metastases: evolution from multiple cystic cavities to nodules during therapy¶
Authors: Yang C et al. | Journal: BMC Infect Dis | Date: 2026 Jun 13
DOI: 10.1186/s12879-026-13809-2
TL;DR: 59歲食道癌術後患者pulmonary tuberculosis以多發囊性空洞表現，治療中轉為結節、似cystic metastases，8個月近完全消退。
嘻嘻：TB扮轉移癌，最後還是被治療收服。
A polymicrobial opportunistic infection leading to osteolytic destruction and acute respiratory failure: a case report¶
Authors: Huang Y et al. | Journal: BMC Infect Dis | Date: 2026 Jun 13
DOI: 10.1186/s12879-026-13423-2
TL;DR: 糖尿病患者polymicrobial infection含Cryptococcus、Pseudomonas aeruginosa、Aspergillus與Mycobacterium abscessus；反覆評估與mNGS促成標靶治療後出院。
嘻嘻：多病原大亂鬥，mNGS這次真的有救場。
Diagnostic Performance and Clinical Impact of Metagenomic Next-Generation Sequencing in 841 Patients with Suspected Lower Respiratory Tract Infections: A Four-Year Retrospective Study from a Tertiary Hospital in Shenzhen, China¶
Authors: Huiling Y et al. | Journal: Int J Infect Dis | Date: 2026 Jun 13
DOI: 10.1016/j.ijid.2026.108885
TL;DR: 深圳841名疑似LRTI患者BALF檢測顯示，mNGS較culture提升整體與polymicrobial detection，逾半mNGS-only病原影響治療。
嘻嘻：LRTI查不到病原時，mNGS很會補刀。
Establishing an EU-compliant diagnostic facility for infectious diseases under war conditions in Poltava, Ukraine¶
Authors: Zelinskyy G et al. | Journal: Front Public Health | Date: 2026
DOI: 10.3389/fpubh.2026.1840777
TL;DR: 烏克蘭波爾塔瓦在戰爭中建置EU-compliant ELFA、automated PCR與AST；2024/3–2025/6完成16,633項檢測並發現多種感染。
嘻嘻：戰火下還能升級檢驗，這才是硬實力。
Association Between Sex Hormones and Lipid Profiles Among Adult Tuberculosis Patients in Northwest Ethiopia: A Comparative Cross-Sectional Study¶
Authors: Gebrie E et al. | Journal: Trop Med Int Health | Date: 2026 Jun 15
DOI: 10.1111/tmi.70177
TL;DR: 衣索比亞150名HIV陰性TB患者較對照有testosterone下降與total cholesterol低40.5 mg/dL；男性cholesterol與testosterone高度相關（r=0.658）。
不嘻嘻：TB不只傷肺，代謝也被拖下水。
Improved Tolerability of De Novo Letermovir Over Valganciclovir for Cytomegalovirus Prophylaxis in Seropositive Liver Transplant Recipients¶
Authors: Kleiboeker HL et al. | Journal: Clin Transplant | Date: 2026 Jun
DOI: 10.1111/ctr.70597
TL;DR: 85名CMV R+肝移植者中，letermovir完成率高於valganciclovir（92.0% vs 68.3%），leukopenia與neutropenia較少，1年CMV viremia相近。
嘻嘻：letermovir少掉骨髓麻煩，移植醫師會笑。
Viral hepatitis co-infections with tuberculosis in India: A systematic review and meta-analysis¶
Authors: Chauhan A et al. | Journal: Indian J Med Res | Date: 2026 Jun
DOI: 10.25259/IJMR_3570_2025
TL;DR: 印度11篇、4,502名TB患者meta-analysis顯示，hepatitis B coinfection pooled prevalence 10%，hepatitis C 6%；TB/HIV者HBV達17%。
不嘻嘻：TB遇上hepatitis，肝臟表示別再加班。
Emerging therapeutic strategies in multiple sclerosis: a focus on innovative and targeted approaches¶
Authors: Thalib HI et al. | Journal: Naunyn Schmiedebergs Arch Pharmacol | Date: 2026 Jun 15
DOI: 10.1007/s00210-026-05579-0
TL;DR: MS新療法轉向BTK inhibitors、CAR T-cell therapy、EBV vaccines、remyelination與microbiome；多數仍在早期，長期安全性不足。
嘻嘻：MS新招很多，但安全性帳本還沒結。
Cytomegalovirus Seroprevalence in Morocco - a 10-Year Single-Center Study¶
Authors: Zouaki A et al. | Journal: Clin Lab | Date: 2026 Jun 01
DOI: 10.7754/Clin.Lab.2025.250738
TL;DR: 摩洛哥拉巴特10年11,367人CMV serology顯示，整體seroprevalence 94.1%，年盛行率穩定於92.2%–95.7%。
不嘻嘻：CMV在摩洛哥幾乎全民熟面孔。
Diagnostic and Therapeutic Dilemmas in Recurrent Pulmonary Alveolar Proteinosis After Bilateral Lung Transplantation¶
Authors: Lopez O et al. | Journal: Respirol Case Rep | Date: 2026 Jun
DOI: 10.1002/rcr2.70653
TL;DR: 73歲PAP雙肺移植後逾3年復發，MAC、Aspergillus與Nocardia感染混淆診斷；inhaled sargramostim加兩次WLL後改善。
不嘻嘻：移植後PAP復發，診斷雜訊滿格。
Breakthrough Pulmonary Nocardiosis Due to Nocardia cyriacigeorgica in a Lung Transplant Recipient in Brazil: A Case Report Highlighting Management Without Susceptibility Testing¶
Authors: Vinhaes CL et al. | Journal: Case Rep Infect Dis | Date: 2026
DOI: 10.1155/crdi/2026205
TL;DR: 巴西肺移植8年後突破性pulmonary nocardiosis由Nocardia cyriacigeorgica引起；meropenem加TMP-SMX後臨床與影像改善。
嘻嘻：沒susceptibility也能穩住Nocardia，算漂亮。
Conocarpan and Eupomatenoid-6 as Natural Prototypes for Antituberculosis Compounds¶
Authors: Silva LL et al. | Journal: Int J Microbiol | Date: 2026
DOI: 10.1155/ijm/9147877
TL;DR: conocarpan與eupomatenoid-6對Mtb H37Rv、14株clinical isolates及M. abscessus有MIC 3.90–125 μg/mL；conocarpan與rifampicin具synergism。
嘻嘻：天然物打TB，至少又多幾張牌。
Understanding multi-azole resistance in Aspergillus fumigatus: the impact of non-cyp51A mutation and efflux pump overexpression¶
Authors: Sen P et al. | Journal: Front Fungal Biol | Date: 2026
DOI: 10.3389/ffunb.2026.1830942
TL;DR: 印度156份土壤檢出9株azole-resistant Aspergillus fumigatus；除cyp51A變異外，hmg1 mutations與efflux pump overexpression可能參與resistance。
不嘻嘻：土壤裡的A. fumigatus也在練azole抗性。
Cutaneous Mucormycosis Clinically Mimicking Necrotizing Fasciitis in a Patient Without Active Immunosuppression¶
Authors: İnan AÖ et al. | Journal: Clin Case Rep | Date: 2026 Jun
DOI: 10.1002/ccr3.72900
TL;DR: 70歲男性cutaneous mucormycosis酷似necrotizing fasciitis；amphotericin B腎毒性後改posaconazole，合併清創與植皮後未復發。
不嘻嘻：mucormycosis裝蜂窩性組織炎，真的很會演。
EXPRESS: The Association of Hidradenitis Suppurativa with Increased Risk of Systemic Infections in End-stage Renal Disease¶
Authors: Ntukogu A et al. | Journal: J Investig Med | Date: 2026 Jun 14
DOI: 10.1177/10815589261462559
TL;DR: USRDS 1,397,827名ESRD透析者中HS不增加bacteremia或candidemia診斷，但與septicemia ICD診斷相關（RR 3.24）。
不嘻嘻：ESRD加HS，感染風險帳還是算不清。
A long non-coding RNA regulates in vitro and in vivo triazole antifungal susceptibility in Aspergillus fumigatus¶
Authors: Poudyal NR et al. | Journal: Genetics | Date: 2026 Jun 15
DOI: 10.1093/genetics/iyag152
TL;DR: long non-coding RNA afu-182調控Aspergillus fumigatus sub-MIC azole response；過度表現可降低posaconazole治療小鼠fungal burden。
嘻嘻：lncRNA也能調azole反應，真菌劇本變厚了。
Variation by Race and Ethnicity in the Population Attributable Fractions Associated With Key Tuberculosis Risk Factors in the United States¶
Authors: Ahmed MM et al. | Journal: Public Health Rep | Date: 2026 Jun 14
DOI: 10.1177/00333549261453003
TL;DR: 美國2016–2019年TB的PAF為HIV 5.0%、diabetes 6.7%、incarceration 2.8%、homelessness 4.1%，族群差異明顯。
不嘻嘻：TB風險因子有族群差，公衛不能一招打天下。
Isolated pulmonary Cryptococcus neoformans infection presenting with severe pulmonary involvement: a case report¶
Authors: Ng BH et al. | Journal: J Med Case Rep | Date: 2026 Jun 14
DOI: 10.1186/s13256-026-06241-2
TL;DR: 50歲中國男性糖尿病與低劑量steroid下pulmonary cryptococcosis誤似CAP；BAL culture證實Cryptococcus neoformans，6個月近完全改善。
嘻嘻：Cryptococcus neoformans被揪出後，肺終於喘口氣。
🟢 One Health / Zoonoses¶
The Global Health Security Challenges Posed by Recurring Nipah Virus Outbreaks¶
Authors: M-Kamal HS et al. | Journal: Rev Med Virol | Date: 2026 Jul
DOI: 10.1002/rmv.70154
TL;DR: Nipah virus病死率可逾70%，且南亞outbreak由直接spillover與person-to-person spread增加；無核准vaccine或therapeutics。
不嘻嘻：Nipah還沒疫苗，公衛只能先握緊扶手。
Free-ranging hedgehogs as sentinels of environmental extended-spectrum β-lactamase-producing Enterobacterales¶
Authors: Daniels TZ et al. | Journal: One Health | Date: 2026 Jun
DOI: 10.1016/j.onehlt.2026.101458
TL;DR: 以色列246隻野放hedgehogs中71%帶ESBL-PE、2%帶CRE，E. coli為主；quinolone resistance達83%，可作One Health AMR sentinel。
不嘻嘻：hedgehog都帶ESBL，One Health又多一題。
Transmission and genomic insights into Elizabethkingia miricola: A zoonotic pathogen with intrinsic resistance and nosocomial outbreak potential¶
Authors: Hu S et al. | Journal: One Health | Date: 2026 Jun
DOI: 10.1016/j.onehlt.2026.101465
TL;DR: 5株臨床Elizabethkingia miricola基因體與全球株比較顯示，amphibian株落在clinical lineages，並有院內與跨國傳播風險。
不嘻嘻：Elizabethkingia miricola跨界跑，院感神經要繃緊。
One Health ethics in context: Justice, interdependence, and normative pluralism¶
Authors: Ford A et al. | Journal: One Health | Date: 2026 Jun
DOI: 10.1016/j.onehlt.2026.101467
Detection of bovine coronavirus in myocardial tissue of a naturally infected calf¶
Authors: Vasinioti VI et al. | Journal: One Health | Date: 2026 Jun
DOI: 10.1016/j.onehlt.2026.101464
TL;DR: 自然感染犢牛肺與心臟均檢出BCoV RNA與antigen，心臟主要在conduction system與endothelial cells，首次支持BCoV cardiac involvement。
嘻嘻：BCoV跑到心臟，病理故事又多一章。
Clinical characteristics, antimicrobial susceptibility, and predictors of mortality in Streptococcus suis infection: a retrospective cohort study¶
Authors: Pewton N et al. | Journal: Infection | Date: 2026 Jun 15
DOI: 10.1007/s15010-026-02862-3
TL;DR: 泰國87名S. suis患者院內死亡率11.1%；septic shock增死亡（aOR 14.93），third-generation cephalosporin definitive therapy降死亡（aOR 0.10）。
嘻嘻：S. suis抓到治療線索，豬鏈球菌少點威風。
The population structure of Acinetobacter baumannii isolated from animals: an emerging zoonotic threat¶
Authors: Zheng X et al. | Journal: Appl Environ Microbiol | Date: 2026 Jun 15
DOI: 10.1128/aem.00038-26
TL;DR: 整合509株動物與2,218株人類A. baumannii顯示，伴侶動物株較常屬high AMR group並與人類共享ST，提示跨物種傳播潛力。
不嘻嘻：A. baumannii連寵物圈都可能有人脈。
Development of a recombinant single-cycle influenza viral vector as an intranasal vaccine against SARS-CoV-2¶
Authors: Munro J et al. | Journal: Sci Rep | Date: 2026 Jun 13
DOI: 10.1038/s41598-026-55581-y
TL;DR: single-cycle influenza vector鼻內接種小鼠可誘發SARS-CoV-2 systemic與mucosal antibodies；S-RBD-TM優於S-RBD-Sec，異源boost增加sarbecovirus binding breadth。
嘻嘻：鼻內疫苗若能守黏膜，防線就更前面。
New determinant of influenza hemagglutinin cleavability identified through random mutagenesis for acid-stabilizing mutations¶
Authors: Rimaux S et al. | Journal: Microbiol Spectr | Date: 2026 Jun 15
DOI: 10.1128/spectrum.04123-25
TL;DR: H1 HA random mutagenesis發現D346N使HA0對trypsin activation抗性增12倍；另4個acid-stabilizing mutations降低fusion pH與entry效率。
嘻嘻：influenza HA小變異，竟能改寫活化門檻。
Multi-omics analysis of human patient samples identifies key immune factors in Leptospira infection¶
Authors: Cp J et al. | Journal: Microbiol Spectr | Date: 2026 Jun 15
DOI: 10.1128/spectrum.00047-26
TL;DR: 急性leptospirosis PBMC multi-omics顯示逾5,800個transcript與362個protein差異；16個上調host factors涉及neutrophil activation與cytokine signaling。
嘻嘻：leptospirosis免疫拼圖，multi-omics補上不少片。
TraC promotes complement evasion of Salmonella enterica serovar Choleraesuis by recruiting host C4b-binding protein¶
Authors: Zhuang W et al. | Journal: Microb Pathog | Date: 2026 Jun 13
DOI: 10.1016/j.micpath.2026.108616
TL;DR: S. Choleraesuis traC deletion使serum resistance降73%、HeLa invasion降71%，小鼠血中bacterial load降80%；TraC可招募C4BP逃避complement。
不嘻嘻：S. Choleraesuis會借宿主盾牌，太會鑽漏洞。
Fulminant Aeromonas caviae bacteremia with migratory myalgia: a case report of a CTX-M-3-producing multidrug-resistant strain¶
Authors: Guo L et al. | Journal: BMC Infect Dis | Date: 2026 Jun 13
DOI: 10.1186/s12879-026-13808-3
TL;DR: 71歲男性Aeromonas caviae bacteremia併septic shock，WGS證實blaCTX-M-3、blaTEM-1B與blaOXA-10；ertapenem失敗後biapenem成功。
不嘻嘻：Aeromonas caviae帶MDR，經驗治療又被打臉。
The impact of bacterial and viral diseases on dromedary camel (Camelus dromedarius) welfare: a comprehensive review¶
Authors: Shah SFA et al. | Journal: Front Vet Sci | Date: 2026
DOI: 10.3389/fvets.2026.1795334
TL;DR: dromedary camels全球逾3,500–4,000萬隻；brucellosis、tuberculosis、MERS-CoV等感染造成疼痛、發燒、死亡與行為改變，衝擊One Welfare。
不嘻嘻：駱駝感染牽動人畜福祉，One Health不能裝沒事。
🟡 Food Security / Food Safety¶
Online matrix elimination and high-sensitivity detection of maleic hydrazide in complex vegetable matrices using 2D-IC-IPAD¶
Authors: Luan S et al. | Journal: Food Chem | Date: 2026 Jun 11
DOI: 10.1016/j.foodchem.2026.150042
TL;DR: 2D-IC-IPAD檢測蔬菜maleic hydrazide，回收率95.85%–100.9%、LOD 0.05 μg/g；洋蔥檢出0.86 μg/g，馬鈴薯與大蒜未檢出。
嘻嘻：蔬菜殘留檢測更靈，食安少一點猜謎。
Diverse Applications of Carbon Dots¶
Authors: Gao F et al. | Journal: J Agric Food Chem | Date: 2026 Jun 15
DOI: 10.1021/acs.jafc.6c01872
TL;DR: Carbon dots可促進作物發芽、光合作用與抗逆境，並以fluorescence偵測pesticides/heavy metals、作nonviral gene delivery nanocarriers。
嘻嘻：Carbon dots跨農業與檢測，奈米工具箱變忙。
Pathogen-Associated Molecular Pattern (PAMP)-Induced Peptide LcPIP1 Derived from Litchi Promotes the Resistance of Litchi Fruit against Litchi Downy Blight Caused by Peronophythora litchii¶
Authors: Ye X et al. | Journal: J Agric Food Chem | Date: 2026 Jun 13
DOI: 10.1021/acs.jafc.6c02163
TL;DR: litchi peptide LcPIP1可提升ATP、anthocyanin與lignin累積，啟動Ca2+、ROS與MAPK signaling，增強果實對Peronophythora litchii抗性。
嘻嘻：荔枝也有免疫小幫手，果農會想認識。
Assessment of the 2025 post-market monitoring report of genetically modified oilseed rape 73496¶
Authors: Ardizzone M et al. | Journal: EFSA J | Date: 2026 Jun
DOI: 10.2903/j.efsa.2026.10142
TL;DR: EFSA審查2025年GM oilseed rape 73496 PMM report，雖未提供消費資料，仍判定pre-market risk assessment假設與用途條件仍適用。
不嘻嘻：GM監測資料少一塊，審查還得硬著頭皮。
Hazard-portfolio patterns in US food recall severity reveal transferable pathogen signals and firm-specific compliance signals¶
Authors: Tang JS et al. | Journal: Sci Rep | Date: 2026 Jun 14
DOI: 10.1038/s41598-026-57837-z
TL;DR: openFDA 28,448筆recall顯示firm history baseline已達最佳ML 92%表現；pathogen contamination（Salmonella、Listeria）跨公司穩定預測Class I。
嘻嘻：recall資料會說話，廠商履歷藏很多線索。
Evaluating hygienic practices in cattle slaughterhouses and beef retail shops in Sidama region, Ethiopia: implications for public health¶
Authors: Syoum A et al. | Journal: Sci Rep | Date: 2026 Jun 13
DOI: 10.1038/s41598-026-57493-3
TL;DR: 衣索比亞190名屠宰與零售肉品工作者中，良好處理僅45%與21%；food safety training提升衛生實務（AOR 5.03、3.96）。
不嘻嘻：肉品衛生靠訓練，基本功還是最大坑。
Micronutrient intake and food insecurity among mothers of infants with orofacial clefts: a cross-sectional study in Iran¶
Authors: Kalantar-Hormozi A et al. | Journal: Sci Rep | Date: 2026 Jun 13
DOI: 10.1038/s41598-026-57977-2
TL;DR: 伊朗orofacial clefts嬰兒母親常見iron 91.0%、vitamin D 73.6%、folate 60.2%攝取不足；food insecurity與cleft嚴重度有trend（P=0.028）。
不嘻嘻：孕期營養缺口，常常比想像更安靜。
Enhanced multi-attribute decision-making method to analyze renewable energy sources for sustainable transportation by synergizing the cubic set with picture fuzzy hypersoft sets¶
Authors: Sajid M et al. | Journal: Sci Rep | Date: 2026 Jun 13
DOI: 10.1038/s41598-026-50529-8
TL;DR: 巴基斯坦永續運輸能源評估提出CPFHSS decision-making方法，整合專家對solar、wind、hydropower等選項的樂觀與悲觀判斷。
嘻嘻：永續運輸選能源，模糊決策也能更有章法。
Prevalence, species diversity, and antimicrobial resistance profile of Listeria monocytogenes in retail meat and dairy products in Southern Ethiopia¶
Authors: Ifa AC et al. | Journal: Sci Rep | Date: 2026 Jun 13
DOI: 10.1038/s41598-026-56187-0
TL;DR: 衣索比亞422件零售肉乳品中Listeria spp. 16.4%、L. monocytogenes 5.9%；cheese最高12.9%，penicillin resistance達100%。
不嘻嘻：Listeria monocytogenes躲乳肉品，冰箱也不安心。
Prophage genomics of carbapenemase-producing Klebsiella pneumoniae from animal-derived food sources¶
Authors: Sabala RF et al. | Journal: Sci Rep | Date: 2026 Jun 13
DOI: 10.1038/s41598-026-54139-2
TL;DR: 埃及23株食品來源CRKP中鑑定18個intact prophages；部分incomplete prophages帶blaSHV，提示動物性食品可作AMR與virulence mobilome reservoir。
不嘻嘻：食品CRKP帶prophage，AMR劇情又加支線。
Retail cattle meat as a reservoir of multidrug-resistant Salmonella harboring β-lactamase genes in Sylhet, Bangladesh¶
Authors: Lasker RM et al. | Journal: Vet Res Commun | Date: 2026 Jun 13
DOI: 10.1007/s11259-026-11344-8
TL;DR: 孟加拉Sylhet 300件牛肉swab中S. enterica陽性27.3%，含S. Typhimurium 13.7%、S. Enteritidis 10.3%，全株MDR且blaTEM常見。
不嘻嘻：牛肉裡的Salmonella全MDR，烤熟只是基本。
Antibacterial and antioxidant activity of ginsenosides from ginseng rootlets and their application in beef preservation¶
Authors: Zhang J et al. | Journal: World J Microbiol Biotechnol | Date: 2026 Jun 15
DOI: 10.1007/s11274-026-05089-4
TL;DR: ginseng rootlet ginsenosides對E. coli最強，DIZ 10.25 mm、MIC 2.85 mg/mL；2%與4%處理分別延長絞牛肉保存2與4天。
嘻嘻：ginsenosides能護牛肉，天然保鮮有點香。
Integrating uncertainty into official control decisions: Bayesian risk-based decision support for the safe reopening of live bivalve mollusk harvesting areas¶
Authors: Ciccarelli C et al. | Journal: Ital J Food Saf | Date: 2026 Jun 12
DOI: 10.4081/ijfs.2026.15116
TL;DR: Bayesian β-binomial框架把E. coli、Salmonella、norovirus等prior evidence納入貝類採收區reopening決策，可量化殘餘污染風險與不確定性。
嘻嘻：貝類復採加上Bayesian，不確定性終於可量化。
Genomic characterization of antimicrobial resistance, virulence, and transmission of non-typhoidal Salmonella from retail red meat in Hunan, China¶
Authors: Chen S et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1840000
TL;DR: 中國湖南147株零售紅肉non-typhoidal Salmonella中78.2%具抗藥性、62.6%為MDR；rmtB 2.0%、blaCTX-M-55 4.1%，typhoid toxin cluster 9.5%。
不嘻嘻：紅肉Salmonella抗藥性高，餐桌版AMR警報。
資料來源：PubMed (articles retrieved 2026-06-16)