Daily Journal Digest — 2026-06-09¶
過去 24 小時新增：Transplant ID × 19、One Health × 11、Food Security × 12，共 42 篇。
🔴 Transplant & Opportunistic Infections¶
Nebulized amphotericin B deoxycholate in management of chronic pulmonary aspergillosis: experience from a tertiary care centre in North India¶
Authors: Sehgal IS et al. | Journal: J Antimicrob Chemother | Date: 2026 Jun 03
DOI: 10.1093/jac/dkag200
TL;DR: 36例CPA使用nebulized amphotericin B deoxycholate維持治療，中位追蹤27個月；6/7-day緩解維持率84.2%，優於alternate-day的46.7%，不良事件22.2%。
嘻嘻：吸進去也能撐住CPA，門診終於多一點底氣。
Gene-edited live-attenuated vaccines against Toxoplasma gondii: recent advances and future frontiers¶
Authors: Sang X et al. | Journal: Parasit Vectors | Date: 2026 Jun 07
DOI: 10.1186/s13071-026-07454-6
TL;DR: CRISPR-Cas9 gene-edited live-attenuated vaccines在小鼠可誘發IgG2a、IFN-γ、IL-12與T-cell反應，保護對抗T. gondii致死感染並減少tissue cysts。
嘻嘻：CRISPR疫苗打出免疫感，T. gondii先別太囂張。
Development and Field Validation of a Double-Antigen Sandwich Colloidal Gold Immunochromatographic Strip for Detection of Toxoplasma gondii Antibodies in Multiple Host Species¶
Authors: Mu X et al. | Journal: Transbound Emerg Dis | Date: 2026
DOI: 10.1155/tbed/5879710
TL;DR: rSAG2-GICA可跨物種偵測T. gondii antibodies，409件動物血清陽性率2.9%–31.3%；與ELISA整體一致率雞91.3%、狗97.7%。
嘻嘻：一條strip跨物種抓抗體，獸醫現場會很開心。
Chronic invasive Aspergillus Fumigatus rhinosinusitis with intracranial extension¶
Authors: Kremsmayer T et al. | Journal: IDCases | Date: 2026
DOI: 10.1016/j.idcr.2026.e02618
TL;DR: 63歲糖尿病男性慢性侵襲性Aspergillus fumigatus rhinosinusitis延伸至眼眶與顱內，逾1年amphotericin、isavuconazole、micafungin仍惡化。
不嘻嘻：Aspergillus闖進顱內，藥單再長也很無力。
Severe Post-Tuberculosis Bronchiectasis With Bullous Lung Disease Complicated by Acute Infective Exacerbation: A Case Report From Uganda¶
Authors: Sandeyl AA et al. | Journal: Clin Case Rep | Date: 2026 Jun
DOI: 10.1002/ccr3.72854
TL;DR: 烏干達60歲男性suboptimally treated PTB後嚴重bronchiectasis與bullae，痰培養長Pseudomonas aeruginosa、Streptococcus pneumoniae；culture-directed therapy後改善。
嘻嘻：舊TB爛攤子還能救，培養結果真的是方向燈。
Trends in incidence and DALYs of infectious disease from 2000 to 2023 and the attributable risk factors in China: an analysis of the Global Burden of Disease Study 2023¶
Authors: Zhou L et al. | Journal: Lancet Reg Health West Pac | Date: 2026 Jun
DOI: 10.1016/j.lanwpc.2026.101884
TL;DR: 中國2000–2023年infectious disease DALYs多數下降；enteric infections ASDR由365.4降至43.8/10萬，HIV/AIDS與STI則升至103.7/10萬。
不嘻嘻：大多往下很好，但HIV/STI偏要逆風上樓。
Access to diagnosis using liquid biopsy (ADLiB): Identifying lymphoma in a tuberculosis-endemic setting¶
Authors: Antel K et al. | Journal: Hemasphere | Date: 2026 Jun
DOI: 10.1002/hem3.70394
TL;DR: 南非124例lymphadenopathy中，ADLiB以plasma cfDNA區分malignant與benign，sensitivity 95%、specificity 75%、accuracy 92%，AUC 0.89。
嘻嘻：TB盛行區用cfDNA分流，少走冤枉路太重要。
Bone Marrow Examination in the Diagnosis of Infectious Pathology: An Often Underutilized Diagnostic Tool¶
Authors: Maharjan M et al. | Journal: Cureus | Date: 2026 May
DOI: 10.7759/cureus.108330
TL;DR: 6年BME診斷29例感染，leishmaniasis占65.5%，tuberculosis與histoplasmosis各10.3%；PUO合併anemia、plasmacytosis時可提升快速診斷。
嘻嘻：Bone marrow examination老工具，關鍵時刻仍很能打。
Epstein-Barr virus and oral health: epidemiology, pathogenesis, clinical aspects, and diagnostic insights: a narrative review¶
Authors: Sriram S et al. | Journal: Ann Med Surg (Lond) | Date: 2026 Jun
DOI: 10.1097/MS9.0000000000005034
TL;DR: EBV口腔表現含palatal petechiae、oral hairy leukoplakia與ulcers，並可能連結periodontitis與oral cancer；診斷需PCR、in situ hybridization與serology整合。
不嘻嘻：EBV在口腔戲份太多，牙科也被拖下水。
Letermovir does not affect long-term polyclonal immune reconstitution after allogeneic hematopoietic stem cell transplantation with ATG-based GvHD prophylaxis¶
Authors: Weidt C et al. | Journal: Front Immunol | Date: 2026
DOI: 10.3389/fimmu.2026.1790563
TL;DR: 276名HCMV-seropositive allo-SCT患者中，letermovir使100天clinically significant HCMV infections由68.4%降至28.3%，18個月IR相近（24% vs 27%）。
嘻嘻：letermovir降CMV又不亂免疫，這很可以。
Burden of infectious diseases in children during the first year after solid organ transplantation¶
Authors: Rock NM et al. | Journal: Transpl Int | Date: 2026
DOI: 10.3389/ti.2026.16075
TL;DR: 瑞士285名pediatric SOT一年內53%至少一次感染、共360次，incidence 1.36/person-year；viral infections占53%，肝與肺移植感染率最高。
不嘻嘻：小朋友SOT第一年，感染像例行公事般報到。
Utility of Cytopathology in Diagnosing a Plethora of Fungal Infections¶
Authors: Suneja P et al. | Journal: J Cytol | Date: 2026
DOI: 10.4103/joc.joc_43_25
TL;DR: 5年25例FNAC診斷fungal infections，以rhino-orbital cerebral mucormycosis最多（15例）；FNAC可在臨床未疑及時協助早期治療。
嘻嘻：FNAC抓fungal infection，便宜快狠準最香。
Characterizing isoniazid preventive therapy uptake among people living with human immunodeficiency virus in Tanzania, a resource-constrained setting with a high tuberculosis burden: A systematic review and meta-analysis¶
Authors: Sindato EM et al. | Journal: IJID Reg | Date: 2026 Jun
DOI: 10.1016/j.ijregi.2026.100908
TL;DR: 坦尚尼亞PLHIV的isoniazid preventive therapy uptake僅23.61%（95% CI 14.00–34.83），但完成率82.40%；IPT中TB發生率2.72%。
不嘻嘻：IPT完成率漂亮，問題是很多人根本沒上車。
RASGRP1 Deficiency Manifesting as Severe Vasculopathy and Fatal Autoimmune Hemolytic Anemia¶
Authors: Ashari KA et al. | Journal: EJHaem | Date: 2026 Jun
DOI: 10.1002/jha2.70275
TL;DR: RASGRP1 deficiency病例回顧15例顯示infections 100%、lymphoproliferation 87%；新病例以severe vasculopathy與fatal autoimmune hemolytic anemia呈現。
不嘻嘻：RASGRP1 deficiency把免疫學教成恐怖片。
Predictors of Mucormycosis in Hospitalized Patients with Postcoronavirus Disease 2019: A Role of Metabolic and Micronutrient Factors¶
Authors: Shabbir N et al. | Journal: Ann Afr Med | Date: 2026 Jun 05
DOI: 10.4103/aam.aam_52_26
TL;DR: 139名post-COVID-19患者中94例mucormycosis；diabetes 87.2%、steroid exposure 85.1%與ICU較久相關，Vitamin B12、folate異常也可能重要。
不嘻嘻：post-COVID mucormycosis提醒我們代謝債會追來。
Updating CMV protocols in lung transplant patients: a single-center case study modeling use of generative AI for antimicrobial stewardship protocol development and economic impact analysis¶
Authors: Enriquez KT et al. | Journal: Infect Control Hosp Epidemiol | Date: 2026 Jun 08
DOI: 10.1017/ice.2026.10480
TL;DR: Microsoft CopilotTM為165例肺移植cohort建CMV prophylaxis模型，protocol未hallucination但偏保守，較guideline與院內protocol每人多花4740美元。
不嘻嘻：AI沒亂講但很會花錢，stewardship錢包先哭。
A rare case of orbital heavy chain amyloidosis¶
Authors: Majumdar B et al. | Journal: Orbit | Date: 2026 Jun 07
DOI: 10.1080/01676830.2026.2681055
TL;DR: 65歲女性腎移植與tuberculosis病史，眼眶無痛腫塊經biopsy與tandem mass spectrometry診斷heavy chain amyloidosis；無全身侵犯可觀察追蹤。
嘻嘻：罕見眼眶腫塊能釘出診斷，病理仍是王牌。
Herpesvirus Retinitis by Immune Status: Clinical Phenotypes and Predictors of Retinal Detachment and Severe Visual Impairment¶
Authors: Zou Y et al. | Journal: Ophthalmol Retina | Date: 2026 Jun 06
DOI: 10.1016/j.oret.2026.06.002
TL;DR: 120例herpesvirus retinitis追蹤5.5年，ARN較早且較常retinal detachment；ARN（HR 11.52）與較差baseline visual acuity預測RD。
不嘻嘻：ARN一出手就瞄準retina，眼科壓力很真實。
Impact of fluconazole non-susceptibility on 30-day mortality in Candida tropicalis invasive candidiasis: Insights from a region with low resistance prevalence¶
Authors: Lin GL et al. | Journal: J Glob Antimicrob Resist | Date: 2026 Jun 06
DOI: 10.1016/j.jgar.2026.06.001
TL;DR: 南台灣341例Candida tropicalis invasive candidiasis 30天死亡率45.8%、FNS 8.2%；死亡主要由宿主因素與fungemia驅動，FNS非獨立因子。
不嘻嘻：C. tropicalis死亡率高到抗藥性都不是主角。
🟢 One Health / Zoonoses¶
Identification and phylogenetic analysis of seven Brucella abortus strains in Zhejiang, China¶
Authors: Yang Y et al. | Journal: Front Cell Infect Microbiol | Date: 2026
DOI: 10.3389/fcimb.2026.1758965
TL;DR: 中國浙江7株Brucella abortus皆為ST2，ANI對參考株99.99%；cgSNP顯示與俄羅斯參考株成monophyletic cluster並分三個subclades。
不嘻嘻：Brucella系譜又牽出跨境線索，公衛不會無聊。
Community knowledge, attitudes and practices related to cystic echinococcosis in Ethiopia: Implications for control¶
Authors: Efa DA et al. | Journal: One Health | Date: 2026 Jun
DOI: 10.1016/j.onehlt.2026.101456
TL;DR: 衣索比亞310人KAP調查顯示逾半對cystic echinococcosis知識有限且行為高風險；教育程度與較佳知識、安全practice強相關。
不嘻嘻：cystic echinococcosis控制，最後還是輸給日常習慣。
Development and implementation of an animal-inclusive Community-Led Total Sanitation program for rural Mali¶
Authors: Dione M et al. | Journal: One Health | Date: 2026 Jun
DOI: 10.1016/j.onehlt.2026.101449
TL;DR: 馬利25村pilot中，A-CLTS組10村有6村達animal-inclusive ODF，CLTS+A為4/10，standard CLTS僅1/5；納入動物糞便管理可提升成效。
嘻嘻：把動物糞便納入 sanitation，終於正視現場生活。
Determinants of antimicrobial resistance practices in Ethiopia: A One Health mixed-methods study¶
Authors: Assefa GM et al. | Journal: One Health | Date: 2026 Jun
DOI: 10.1016/j.onehlt.2026.101461
TL;DR: 衣索比亞One Health mixed-methods研究納入750戶與251名animal health professionals；attitude最穩定連結較佳AMR practice（aOR 1.26與1.50）。
嘻嘻：AMR practice先從態度改起，One Health很務實。
Magnolol ameliorates Streptococcus suis serotype 2-induced pulmonary inflammatory injury in mice via inhibition of GSDMD¶
Authors: Liao J et al. | Journal: Microb Pathog | Date: 2026 Jun 06
DOI: 10.1016/j.micpath.2026.108614
TL;DR: 小鼠與macrophage實驗顯示magnolol降低Streptococcus suis serotype 2誘發肺部發炎傷害、IL-1β/IL-18與GSDMD，效果類似GSDMD-deficient mice。
嘻嘻：magnolol壓GSDMD，老天然物也能有新戲路。
Genetic Characterization of Swine Influenza Viruses in Thailand in 2019-2025 Reveals Novel Reassortants¶
Authors: Chaiyawong S et al. | Journal: Transbound Emerg Dis | Date: 2026
DOI: 10.1155/tbed/9516354
TL;DR: 泰國2019–2025年1629件豬鼻拭子10.87% swIAV陽性，分離30株含H1N1、H1N2、H3N2；WGS發現8種genotypes與4種新reassortants。
不嘻嘻：swIAV重組玩不停，豬場監測不能打瞌睡。
Echinococcus Equinus Found in Imported Donkeys (Equus asinus) From Central Asia¶
Authors: Cui N et al. | Journal: Transbound Emerg Dis | Date: 2026
DOI: 10.1155/tbed/9570858
TL;DR: 1900頭中亞進口驢中18頭（0.9%）檢出Echinococcus equinus，52個hydatid cysts來自肝肺；小鼠感染180天後3/18出現肝cysts。
不嘻嘻：進口驢也帶寄生蟲彩蛋，邊境檢疫很有感。
Protective Immunity Induced by DNA Vaccines Encoding TgGRA47 and TgGRA72 Against Toxoplasma gondii Infection in BALB/c Mice¶
Authors: Zhou Z et al. | Journal: Transbound Emerg Dis | Date: 2026
DOI: 10.1155/tbed/9513737
TL;DR: pVAX-GRA47與pVAX-GRA72 DNA vaccines在BALB/c小鼠對T. gondii PRU strain誘發humoral、Th1與Th17 protective immunity，具候選疫苗潛力。
嘻嘻：DNA vaccine打出Th1/Th17，T. gondii壓力上升。
Mechanistic Landscape and Farm to Fork Control Strategies for Streptococcus suis: An Emerging Foodborne Threat¶
Authors: Yao W et al. | Journal: Transbound Emerg Dis | Date: 2026
DOI: 10.1155/tbed/1603643
TL;DR: Streptococcus suis全球逾1600例人類確診、pooled case-fatality約12%，東亞逾18%；review整理BBB invasion、biofilm與疫苗/diagnostic targets。
不嘻嘻：S. suis從豬到餐桌，吃貨人生突然嚴肅。
Epidemiological and Genomic Characteristics of bla CTX-M and bla NDM-Producing K. pneumoniae From Dairy Cows in Henan Province, China¶
Authors: Feng Y et al. | Journal: Transbound Emerg Dis | Date: 2026
DOI: 10.1155/tbed/5331014
TL;DR: 中國河南180件乳牛mastitic milk分離65株Klebsiella，31株ESBL、1株K. pneumoniae帶bla NDM-1；87.1% ESBL producers為MDR。
不嘻嘻：乳牛場冒出bla NDM-1，One Health警鈴很大聲。
Temporal trends in Salmonella serovar distribution and antimicrobial resistance profiles, including plasmid-mediated colistin resistance, among livestock-derived isolates in South Korea, 2019-2024¶
Authors: Ali MS et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1821233
TL;DR: 南韓2019–2024年4198株畜牧來源Salmonella中78.7%具抗藥性、50.5%為MDR；S. Infantis MDR達90.7%，mcr-1位於IncX4/IncI2 plasmids。
不嘻嘻：Salmonella MDR配mcr-1，畜牧端真的很會加戲。
🟡 Food Security / Food Safety¶
A novel fluorescent sensor based on CdTe quantum dots and DTAB-modified Au nanoparticles through aggregation-induced fluorescence recovery for the detection of l-lysine¶
Authors: Min X et al. | Journal: J Sci Food Agric | Date: 2026 Jun 07
DOI: 10.1002/jsfa.70784
TL;DR: CdTe quantum dots與DTAB-AuNPs建立off-on fluorescent sensor偵測l-lysine，線性範圍0.5–10 μm、R=0.999、LOD 3.22 nm，已用於乳品與黃豆樣本。
嘻嘻：l-lysine sensor靈敏到很誇張，食品檢測添新招。
Smart detection of juice adulteration: An approach based on ion mobility spectrometry and machine learning¶
Authors: Calle JLP et al. | Journal: J Sci Food Agric | Date: 2026 Jun 07
DOI: 10.1002/jsfa.70781
TL;DR: HS-GC-IMS結合machine learning可量化果汁摻白葡萄汁；SVR表現最佳，RMSE 1.831、R2 0.987，並提供web app輔助資料處理。
嘻嘻：果汁摻假遇上IMS加ML，騙味蕾不等於騙機器。
Improving Microbial Quality of Ostrich Meat Using Mechanically Deboned Chicken Meat Protein Nanocomposite Coating Incorporated With Ziziphora clinopodioides Essential Oil and Eugenol During Cold Storage¶
Authors: Barkhordari H et al. | Journal: Food Sci Nutr | Date: 2026 Jun
DOI: 10.1002/fsn3.71759
TL;DR: 含ZEO與EUG的MDCM-P nanocomposite coating於4°C保存21天可降低鴕鳥肉總菌數9.29至6.33 log10 CFU/g，並降低S. aureus與E. coli O157:H7。
嘻嘻：肉品coating能壓菌，冷藏櫃終於少點驚喜。
Breastfeeding Practices, Insomnia Symptoms, Anxiety, and Depression Among Lebanese Mothers: A Cross-Sectional Study¶
Authors: Boutros PH et al. | Journal: Food Sci Nutr | Date: 2026 May
DOI: 10.1002/fsn3.71830
TL;DR: 黎巴嫩305名產後母親中，6個月exclusive breastfeeding與insomnia、anxiety、depression無關；12–24個月持續哺乳與insomnia相關（aOR 2.15）。
不嘻嘻：產後睡不好已夠累，哺乳研究還來補刀。
Radionuclides in Milk: A Global Systematic Review and Meta-Analysis and Probabilistic Human Risk Assessment¶
Authors: Fakhri Y et al. | Journal: Food Sci Nutr | Date: 2026 May
DOI: 10.1002/fsn3.71770
TL;DR: 66篇、32國牛奶radionuclides meta-analysis顯示全球pooled mean以K-40最高57.494 Bq/L；多國Cs-137、K-40、I-131或Pb-210癌症風險超過1E-4。
不嘻嘻：牛奶裡談radionuclides，早餐突然變沉重。
Vendor Hygiene Practices, Temporal Variation, and Microbial Quality of Soya Kebabs Sold in Public and Private Basic Schools in Sunyani, Ghana¶
Authors: Amponsah AS et al. | Journal: Food Sci Nutr | Date: 2026 May
DOI: 10.1002/fsn3.71909
TL;DR: 迦納25校50件soya kebabs檢出污染隨週期變動，S. aureus 2.28–4.12 log10 CFU/g；僅16%攤商洗手合格，hygiene score與污染高度負相關。
不嘻嘻：soya kebabs遇到手部衛生，校園點心瞬間不香。
Discrimination of the S-isomer of ofloxacin using nanozyme-enhanced immunochromatographic analysis based on a secondary antibody-modified Au@Pd nanozyme¶
Authors: Hendrickson OD et al. | Journal: Mikrochim Acta | Date: 2026 Jun 08
DOI: 10.1007/s00604-026-08172-7
TL;DR: Au@Pd nanozyme-enhanced ICA可20分鐘偵測S-ofloxacin，instrumental LOD 1.4 pg/mL、cutoff 0.1 ng/mL，較傳統gold nanoparticle ICA敏感60與10倍。
嘻嘻：nanozyme讓ICA開外掛，20分鐘抓到超低濃度。
Characterization of bacteriocin, probiotic attributes and genomic information of Bacillus subtilis S1¶
Authors: Jain PM et al. | Journal: World J Microbiol Biotechnol | Date: 2026 Jun 08
DOI: 10.1007/s11274-026-05070-1
TL;DR: Bacillus subtilis S1基因體4.48 Mb、含4969個protein-coding sequences，具acid/bile tolerance並產Subtilosin A，可抑制Listeria monocytogenes。
嘻嘻：B. subtilis S1會撐胃酸又抗Listeria，益生菌履歷不錯。
Heat stress variation exerts a more pronounced effect than vapor pressure deficit on maize yield in Northeast China¶
Authors: Sun S et al. | Journal: Int J Biometeorol | Date: 2026 Jun 08
DOI: 10.1007/s00484-026-03227-z
TL;DR: 中國東北1981–2022年玉米資料顯示BRT模型CV correlation 0.78–0.88；reproductive phase的HDD anomalies是產量下降最重要氣候因子，強於VPD。
不嘻嘻：熱傷害比VPD更狠，玉米也怕夏天加班。
Restoring a synthetic methylxanthine degradation operon to its native genes¶
Authors: Nguyen ST et al. | Journal: MicroPubl Biol | Date: 2026
DOI: 10.17912/micropub.biology.002105
TL;DR: Caffeinated Coli恢復Pseudomonas putida ndmE至decaffeination operon後，多數N7-demethylating strains可在略高溫度生長，改善gst9替代的限制。
嘻嘻：Caffeinated Coli修回native基因，咖啡因代謝更順。
Investigating Stress Tolerance of Multiple Salmonella enterica Strains Associated With Foodborne Outbreaks¶
Authors: Martin A et al. | Journal: Int J Microbiol | Date: 2026
DOI: 10.1155/ijm/9940898
TL;DR: 43株outbreak與nonoutbreak Salmonella enterica中34株帶AMR genes，21株對ampicillin、ciprofloxacin或ceftriaxone具genotypic/phenotypic resistance；3株56°C存活逾60分鐘。
不嘻嘻：Salmonella又抗藥又耐熱，廚房安全別靠運氣。
Microbial Contamination and Molecular Identification of Predominant Bacteria in Fermented Milk Products in Mbarara, Uganda¶
Authors: Kamwine M et al. | Journal: Cureus | Date: 2026 May
DOI: 10.7759/cureus.108346
TL;DR: 烏干達192件發酵乳品中，175件培養有12.0%檢出至少一種pathogen，起司污染率最高42.9%；16S確認Klebsiella spp與Enterobacter spp等潛在pathogens。
不嘻嘻：發酵乳品不該抽到pathogen盲盒，監管要醒著。
資料來源：PubMed (articles retrieved 2026-06-09)