Daily Journal Digest — 2026-06-07¶

過去 24 小時新增：Transplant ID × 5、One Health × 10、Food Security × 10，共 25 篇。

🔴 Transplant & Opportunistic Infections¶

Survival and risk factors of mortality among patients with TB/HIV coinfection in Kigali City, Rwanda: a retrospective cohort study (2019-2024)¶

Authors: Ndabana D et al. | Journal: BMC Infect Dis | Date: 2026 Jun 05
DOI: 10.1186/s12879-026-13744-2
TL;DR: 盧安達吉佳利1,966名TB/HIV coinfection患者168天死亡率13.4%，78.8%死亡發生於56天內；undernutrition、CD4<200、comorbidities與未接受TPT/CPT增加死亡風險。

不嘻嘻：TB/HIV還是很會搶時間，慢一步就很難追。

Risk factors and predictive model of poor graft function after allogeneic hematopoietic stem cell transplantation¶

Authors: Gao M et al. | Journal: Transplant Cell Ther | Date: 2026 Jun 04
DOI: 10.1016/j.jtct.2026.05.043
TL;DR: 795名allo-HSCT血液惡性腫瘤患者中，PGF與較低CD34+ cell dose、infection、CMV activation、splenomegaly、anti-HLA antibody相關；3年OS為50.6% vs 78.1%。

不嘻嘻：allo-HSCT後一感染，骨髓表現就開始臉色難看。

Infectious complications in paediatric kidney transplantation: prevention and management¶

Authors: Macdonald ANG et al. | Journal: Pediatr Nephrol | Date: 2026 Jun 06
DOI: 10.1007/s00467-026-07378-4
TL;DR: 兒童kidney transplantation後infection仍是morbidity、allograft failure與死亡主因；因對CMV、EBV較少既有immunity，需精準donor screening、prophylaxis與及早治療。

不嘻嘻：小兒kidney transplantation，免疫空窗真的不給人鬆懈。

Pneumocystis prophylaxis in rheumatic disease¶

Authors: Wolfe RM et al. | Journal: Best Pract Res Clin Rheumatol | Date: 2026 Jun 05
DOI: 10.1016/j.berh.2026.102164
TL;DR: Rheumatic disease患者PJP雖少見但致死率可高於HIV族群；ANCA-associated vasculitis induction、anti-MD5+ dermatomyositis與VEXAS合併高劑量glucocorticoid時應常規prophylaxis。

不嘻嘻：PJP平常安靜，一出手就很會讓人加班。

Comparison of cationic beta-glucans with antifungal properties - Correlation between chemical structure and biological activity¶

Authors: Skóra M et al. | Journal: Int J Biol Macromol | Date: 2026 Jun 04
DOI: 10.1016/j.ijbiomac.2026.152888
TL;DR: Cationic beta-glucans對多種真菌具選擇性抑制，MIC 0.49–31.25 mg/L；活性與cationization程度及分子量相關，且in vitro毒性低、Galleria模型有效。

嘻嘻：beta-glucans看起來有戲，真菌戰線多一張牌。

🟢 One Health / Zoonoses¶

Human angiotensin‑converting enzyme 2‑specific benzothiazole-based allosteric inhibitor against pan‑sarbecoviruses¶

Authors: Liu L et al. | Journal: Nat Commun | Date: 2026 Jun 06
DOI: 10.1038/s41467-026-73944-x
TL;DR: MB-32為ACE2 allosteric inhibitor，可阻斷SARS-CoV-2 variants、SARS-CoV-1與多種sarbecoviruses進入細胞；鼻內給藥保護小鼠與倉鼠，並阻止Omicron接觸傳播。

嘻嘻：直接卡ACE2，這招對sarbecoviruses很有想像力。

Phylogenetic Analysis of blaCTX-M and blaTEM Genes in E. coli from Hospital Wastewater¶

Authors: Dayrit GB et al. | Journal: Ecohealth | Date: 2026 Jun 05
DOI: 10.1007/s10393-026-01812-7
TL;DR: 菲律賓馬尼拉與奎松市醫院廢水17株ESBL-producing E. coli帶blaCTX-M-1、blaCTX-M-9、blaTEM-1；phylogenetic analysis顯示與亞洲及全球株系相近，支持廢水AMR監測。

不嘻嘻：醫院廢水又在提醒我們，AMR從不下班。

Brucella abortus-induced neck abscess: a case report in an urban area of Miranda, Venezuela¶

Authors: Carrillo WAM et al. | Journal: BMC Infect Dis | Date: 2026 Jun 05
DOI: 10.1186/s12879-026-13702-y
TL;DR: 委內瑞拉加拉加斯19歲男性因食用乳酪發生Brucella abortus biovar 1頸部abscess，PCR確認；Rifampicin加Doxycycline後完全恢復，為罕見人類表現。

嘻嘻：乳酪送來Brucella，但治療結局還算給面子。

A novel risk stratification model based on creatine kinase and direct bilirubin for identifying severe Chlamydia psittaci pneumonia: a double-center, hypothesis-generating retrospective cohort study¶

Authors: Huang Y et al. | Journal: BMC Infect Dis | Date: 2026 Jun 05
DOI: 10.1186/s12879-026-13738-0
TL;DR: 36名住院Chlamydia psittaci pneumonia患者中，severe組11例；CK與direct bilirubin較高但未達統計顯著，模型僅屬hypothesis-generating，需大型prospective cohort驗證。

不嘻嘻：C. psittaci pneumonia分層，現在還在摸索階段。

Closing the gap on gapeworm: experimental infection of Mammomonogamus ierei in domestic cats¶

Authors: Iani AD et al. | Journal: Parasit Vectors | Date: 2026 Jun 05
DOI: 10.1186/s13071-026-07480-4
TL;DR: 20隻幼貓以6種途徑接種Mammomonogamus ierei L3，僅subcutaneous組2隻於48–51天排卵；首次證實可行感染途徑，但自然傳播意義仍待確認。

嘻嘻：貓模型終於開門，寄生蟲研究多了路徑。

Rickettsiosis: existing advances and future opportunities for the development of vaccines¶

Authors: León-Montoya H et al. | Journal: Vet Res Commun | Date: 2026 Jun 06
DOI: 10.1007/s11259-026-11308-y
TL;DR: Rickettsiosis vaccine研發涵蓋inactivated、live-attenuated、subunit、DNA與nanovaccines，多能誘發immune response，部分可抵抗challenge；仍需解決抗原選擇與保護力驗證。

嘻嘻：Rickettsiosis vaccine有進展，至少不再只靠祈禱。

Immunopharmacologsical and structural insights into Rift Valley fever virus envelope glycoproteins: an immunoinformatics approach to multi-epitope vaccine design¶

Authors: Aziz T et al. | Journal: Naunyn Schmiedebergs Arch Pharmacol | Date: 2026 Jun 06
DOI: 10.1007/s00210-026-05493-5
TL;DR: 針對RVFV Gn/Gc設計multi-epitope vaccine，in silico顯示抗原性高、穩定、全球population coverage >90%，且與TLR4 docking良好；仍需實驗驗證。

嘻嘻：RVFV vaccine設計漂亮，下一關就是離開電腦。

Serological surveillance for malaria elimination in Southeast Asia: a scoping review¶

Authors: Sangaran K et al. | Journal: Malar J | Date: 2026 Jun 05
DOI: 10.1186/s12936-026-05977-y
TL;DR: 東南亞malaria serology scoping review納入2000–2025年33篇研究；antibody surveillance可補足低傳播區診斷缺口，辨識residual hotspots與zoonotic spill-over風險。

嘻嘻：malaria serology很適合抓那些躲起來的尾巴。

Reconsidering the risks of Linguatula in Australia: A review of an overlooked introduced parasite¶

Authors: Shamsi S et al. | Journal: Parasitol Res | Date: 2026 Jun 05
DOI: 10.1007/s00436-026-08705-2
TL;DR: Linguatula serrata在澳洲已於引進與原生宿主間建立傳播，雖未有人類病例通報；因症狀非特異與診斷限制，可能低估其One Health與foodborne風險。

不嘻嘻：Linguatula serrata低調拓荒，診斷卻還在裝睡。

Pregnancy and hantavirus infection: maternal, fetal, and neonatal outcomes - a systematic review¶

Authors: Baradwan S et al. | Journal: Eur J Obstet Gynecol Reprod Biol | Date: 2026 Jun 01
DOI: 10.1016/j.ejogrb.2026.115216
TL;DR: Hantavirus感染妊娠systematic review納入24例，ICU 41.7%、mechanical ventilation 29.2%、母體死亡8.3%；早產33.3%、胎死或stillbirth 16.7%，未證實vertical transmission。

不嘻嘻：懷孕遇上hantavirus，產科和ICU都會皺眉。

🟡 Food Security / Food Safety¶

Antibiofilm Mechanisms and Applications of Natural Compounds¶

Authors: Kim SM et al. | Journal: J Food Prot | Date: 2026 Jun 04
DOI: 10.1016/j.jfp.2026.100825
TL;DR: Natural compounds可抑制biofilm attachment、quorum sensing、c-di-GMP signaling並破壞EPS，也可清除persister bacteria；食品加工應用仍需結合奈米載體、表面塗層與sanitizer synergy驗證。

嘻嘻：antibiofilm天然物很會拆台，persister也被點名。

Microbial innovations for climate-resilient agriculture: mechanisms, applications, and emerging technologies¶

Authors: Das K et al. | Journal: World J Microbiol Biotechnol | Date: 2026 Jun 06
DOI: 10.1007/s11274-026-05031-8
TL;DR: Microbial innovations可透過biofertilizers、biopesticides、mycorrhizal fungi與microbiome engineering提升作物抗旱、耐鹽、抗熱與養分取得；導入仍受技術、生态與社經障礙限制。

嘻嘻：microbiome engineering讓農業抗壓多了生物解方。

Effects of thermal regime variability on adult rainbow trout (Oncorhynchus mykiss) mortality in Afromontane river systems¶

Authors: Mugaviri B et al. | Journal: Environ Monit Assess | Date: 2026 Jun 06
DOI: 10.1007/s10661-026-15536-2
TL;DR: 辛巴威1994–2024年河川資料顯示，夏季Oncorhynchus mykiss死亡遠高於冬季（1272 vs 229），溫度異常與死亡異常強相關（ρ=0.713），15.20°C以上死亡不成比例上升。

不嘻嘻：水溫一飆，O. mykiss就用死亡率抗議。

Unveiling the Nutraceutical Potential of Yam Dioscorea alata L.: A Comprehensive Review¶

Authors: Prajapati KK et al. | Journal: Plant Foods Hum Nutr | Date: 2026 Jun 06
DOI: 10.1007/s11130-026-01525-w
TL;DR: Dioscorea alata綜述指出其saponins與anthocyanins可能帶來antioxidant、anti-inflammatory、antidiabetic、anticancer與gut microbiome調節效果；仍缺足夠phytochemical與臨床研究確認。

嘻嘻：Dioscorea alata很有潛力，但證據還要補作業。

Extracting cropping patterns from remotely sensed images in a mixed single-, double-, and triple-cropping region of Southern China¶

Authors: Li Y et al. | Journal: Environ Monit Assess | Date: 2026 Jun 06
DOI: 10.1007/s10661-026-15530-8
TL;DR: 中國南方混合耕作區以GEE與10-m NDVI建構cropland、cropping intensity與cropping pattern圖，對照田野調查accuracy分別為98.97%、96.47%、87.92%。

嘻嘻：衛星看耕作節奏，農業監測越來越精準。

Heptametallic high‑entropy nanozyme‑based biosensors for detecting bacterial pathogens in food and infected wound¶

Authors: Li X et al. | Journal: Mikrochim Acta | Date: 2026 Jun 06
DOI: 10.1007/s00604-026-08181-6
TL;DR: H-HEzyme colorimetric biosensor可偵測CAT-positive pathogens，牛奶與果汁中Staphylococcus aureus回收率87.79–112.48%；MRSA傷口模型LOD達10^4 CFU/mL，低於臨床閾值10^5。

嘻嘻：nanozyme biosensor很快狠準，食安和傷口都能用。

User experiences with food storage in a meatsafe (mesh-covered food storage cabinet) in an informal settlement in Dhaka, Bangladesh¶

Authors: Rahman MJ et al. | Journal: Trop Med Health | Date: 2026 Jun 05
DOI: 10.1186/s41182-026-00983-x
TL;DR: 孟加拉達卡Korail RCT質性子研究顯示，meatsafe使用率87.7–99.2%仍未減少污染或兒童diarrhoea，主因食物先裸露冷卻、能源不足、淹水與害蟲路徑未被處理。

不嘻嘻：meatsafe很努力，但環境問題不是櫃子能全扛。

Application of the WHO Workload Indicators of Staffing Need (WISN) method to estimate workforce requirements in Italian Local Health Unit Prevention Departments¶

Authors: Colarusso G et al. | Journal: BMC Health Serv Res | Date: 2026 Jun 05
DOI: 10.1186/s12913-026-14874-8
TL;DR: 義大利坎帕尼亞以WHO WISN估算Prevention Departments人力，2022年約短缺76名FTE；缺口集中animal health sector，部分LHU缺18至逾38名FTE。

不嘻嘻：預防部門人力短缺，公共衛生又在硬撐。

Nutritional disparities between urban poor and non-poor Malaysian children under five in the context of the COVID-19 pandemic: a cross-sectional study¶

Authors: Choo MY et al. | Journal: BMC Pediatr | Date: 2026 Jun 05
DOI: 10.1186/s12887-026-07079-9
TL;DR: 馬來西亞雪蘭莪717名6–59月兒童中，urban-poor組underweight較高（13.2% vs 7.0%），urban poverty增加underweight風險（adjusted OR 1.99），minimum dietary diversity具保護效果。

不嘻嘻：貧窮會長進營養曲線裡，疫情只是放大鏡。

Multi-generational effects of salicylic acid on Lipaphis erysimi and induced defense in Brassica juncea¶

Authors: Javed MW et al. | Journal: BMC Plant Biol | Date: 2026 Jun 05
DOI: 10.1186/s12870-026-09170-w
TL;DR: Brassica juncea施用0.5–1 mM salicylic acid可跨兩代降低Lipaphis erysimi存活、繁殖與成長參數，並提升phenolic與flavonoid防禦反應；仍需田間試驗確認效果。

嘻嘻：salicylic acid讓植物防線升級，田間還要驗收。

資料來源：PubMed (articles retrieved 2026-06-07)