Daily Journal Digest — 2026-06-06¶

過去 24 小時新增：Transplant ID × 18、One Health × 12、Food Security × 11，共 41 篇。

🔴 Transplant & Opportunistic Infections¶

Intracellular acidification by microbiota-derived valeric acid facilitates trans-kingdom ecology limiting Candida parapsilosis colonization¶

Authors: Yasuma-Mitobe K et al. | Journal: Cell Host Microbe | Date: 2026 Jun 04
DOI: 10.1016/j.chom.2026.05.008
TL;DR: machine learning從Lachnospiraceae metabolomics找出valeric acid、butyric acid可抑制C. parapsilosis；HCT糞便與小鼠資料支持其透過intracellular acidification限制colonization。

嘻嘻：腸道代謝物又替我們多守一門。

Egg microbiome of the yellow-spotted Amazon river turtle (Podocnemis unifilis) modulates fusariosis fungal infection and hatching success¶

Authors: Carranco AS et al. | Journal: Commun Biol | Date: 2026 Jun 04
DOI: 10.1038/s42003-026-10404-8
TL;DR: 黃斑亞馬遜河龜蛋microbiome影響FSSC fusariosis與孵化；mycobiome evenness較低與感染傾向、強度上升相關，microbial diversity較高則與hatching success較佳相關。

嘻嘻：連龜蛋microbiome都在上感染科。

Diagnostic accuracy study of the multiplex Truenat MTB Ultima/COVID-19 assay for simultaneous detection of Tuberculosis and SARS-CoV2 (COVID-19)¶

Authors: Tootla H et al. | Journal: PLOS Glob Public Health | Date: 2026
DOI: 10.1371/journal.pgph.0005859
TL;DR: 1,928名疑似TB成人中，Truenat MTB Ultima/COVID-19偵測TB sensitivity 79.8%、specificity 98.9%；COVID-19 sensitivity僅64.4%、specificity 99.2%，整體表現未達最佳。

不嘻嘻：multiplex很帥，但臨床還是會皺眉。

Clinical characteristics and outcomes of invasive fungal infections in critically ill patients with liver cirrhosis¶

Authors: Seeßle J et al. | Journal: BMC Infect Dis | Date: 2026 Jun 04
DOI: 10.1186/s12879-026-13709-5
TL;DR: 488名ICU liver cirrhosis患者IFI盛行率6.1%，invasive candidiasis與invasive pulmonary aspergillosis各占46.7%、53.3%；IFI顯著降低30與90天存活，ACLF者尤其高風險。

不嘻嘻：cirrhosis進ICU後真菌很會補刀。

Survival and predictors of mortality among TB-HIV co-infected children attending ART clinics in public hospitals in Addis Ababa, Ethiopia: a retrospective cohort study¶

Authors: Habteyes AT et al. | Journal: BMC Infect Dis | Date: 2026 Jun 04
DOI: 10.1186/s12879-026-13716-6
TL;DR: 阿迪斯阿貝巴241名TB-HIV共感染兒童5年存活率83.31%，死亡率14.5%；低CD4、opportunistic infections史、ART adherence不佳分別使死亡風險升高aHR 2.84、5.04、5.69。

不嘻嘻：兒童TB-HIV照護還是步步驚心。

A pilot study of the CMV inSIGHT T-cell immunity panel to assess cytomegalovirus (CMV) cell mediated immunity (CMI) in allogeneic hematopoietic cell transplant (HCT) recipients¶

Authors: Arya S et al. | Journal: Cytotherapy | Date: 2026 Jun 04
DOI: 10.1016/j.jcyt.2026.102878
TL;DR: 53名接受letermovir的allogeneic HCT成人，D100有73%呈CMV CMI陽性；D100前CMV DNAemia blips與陽性CMV CMI相關，OR 4.89，提示prophylaxis下仍可免疫重建。

嘻嘻：letermovir時代免疫重建有亮點。

Antifungal susceptibility of Aspergillus spp. isolated from coffee beans of Los Santos Coffee Region, Costa Rica¶

Authors: Jaikel-Víquez D et al. | Journal: Front Public Health | Date: 2026
DOI: 10.3389/fpubh.2026.1817727
TL;DR: 哥斯大黎加咖啡豆187株Aspergillus spp.中，A. fumigatus對amphotericin B non-wild type達75%、voriconazole 25%；itraconazole MIC最低且皆為wild type。

不嘻嘻：咖啡香裡也飄著antifungal壓力。

Outcomes of concomitant Pneumocystis jirovecii pneumonia and cytomegalovirus co-infection in non-HIV, mechanically ventilated critically ill patients¶

Authors: Hung WS et al. | Journal: Ann Med | Date: 2026 Dec
DOI: 10.1080/07853890.2026.2677997
TL;DR: 132名非HIV、機械通氣PJP ICU患者中，26例合併CMV；CMV在單變項與ICU死亡較高相關，但多變項非獨立因子，死亡主要與ARDS及PJP治療時間相關。

不嘻嘻：ICU PJP劇本已夠難，CMV還來客串。

Morphine disrupts antigen-presenting cell function through TLR-4 and autophagy pathways¶

Authors: Malik JA et al. | Journal: Mol Biol Rep | Date: 2026 Jun 05
DOI: 10.1007/s11033-026-11785-z
TL;DR: morphine在macrophages與DCs抑制M. tuberculosis、E. coli等antigen uptake、killing與presentation，並下調MHC I/II、CD80/CD86；機轉涉及TLR-4/NF-κB與autophagy。

不嘻嘻：morphine連免疫簡報都幫倒忙。

The clinical profiles and outcomes of patients with herpesviruses in cerebrospinal fluid: 2019 - 2022¶

Authors: Du Plessis WP et al. | Journal: S Afr Med J | Date: 2026 Jun 02
DOI: 10.7196/SAMJ.2026.v116i5.3441
TL;DR: 184名CSF herpesvirus陽性住院者中，HIV占74.5%、EBV占74.5%；僅10.9%被判定為神經症候群病因，院內死亡率21.7%，凸顯CMV治療不足與EBV過度治療問題。

不嘻嘻：CSF PCR陽性不等於真凶，頭更痛。

Molecular Identification and Antifungal Susceptibility Patterns of Candida Species in Pediatric Patients at Tabriz Children's Hospital¶

Authors: Hosseini K et al. | Journal: Biomed Res Int | Date: 2026
DOI: 10.1155/bmri/6685542
TL;DR: 伊朗97株兒科Candida isolates以C. glabrata最多51.5%，67株susceptibility顯示fluconazole與amphotericin B抗藥性普遍；caspofungin對各species仍有97.4–100% susceptibility。

不嘻嘻：兒科Candida用藥選擇越來越窄。

Clinical characteristics and predictors of in-hospital mortality in patients with ANCA-associated vasculitis complicated by diffuse alveolar hemorrhage: a retrospective cohort study¶

Authors: Gao X et al. | Journal: Front Med (Lausanne) | Date: 2026
DOI: 10.3389/fmed.2026.1840399
TL;DR: 58名AAV合併DAH患者院內死亡率22.4%，感染相關septic shock占死亡76.9%；IPA在死亡者達46.2%，但獨立死亡因子為aCCI較高與早期機械通氣。

不嘻嘻：AAV出血已慘，感染還在旁邊加戲。

Genotype distribution of Pneumocystis jirovecii in immunocompromised patients: a single-center molecular epidemiology study¶

Authors: Alencar CS et al. | Journal: Front Fungal Biol | Date: 2026
DOI: 10.3389/ffunb.2026.1841693
TL;DR: 巴西單中心80名疑似PCP免疫低下者中，58份P. jirovecii成功genotyping；genotype 3占69%且跨HIV、solid organ transplant等族群，mixed infections占12%。

嘻嘻：P. jirovecii分型讓傳播線索更清楚。

Prevalence and Risk Factors of Latent Tuberculosis Infection among People Living with HIV in Mongolia¶

Authors: Och N et al. | Journal: Infect Chemother | Date: 2026 Apr 02
DOI: 10.3947/ic.2025.0136
TL;DR: 蒙古196名PLHIV無active TB者，LTBI盛行率39.3%；ART中斷與LTBI高度相關，OR 27.7，TB接觸史亦增加風險，支持系統性LTBI screening與preventive therapy。

不嘻嘻：HIV照護一斷線，TB就準備上場。

Clinic and Provider Innovations to Improve Tuberculosis Infection Screening and Preventive Therapy Uptake in Brazil: Qualitative Findings From the PREVINE-TB Study¶

Authors: Kerrigan D et al. | Journal: J Int Assoc Provid AIDS Care | Date: 2026
DOI: 10.1177/23259582261447940
TL;DR: 巴西PREVINE-TB的38場質性訪談指出，nurse預先篩選、specialized TB clinics、TPT Champions與digital communication可提升PLHIV的QFT+使用與TPT uptake。

嘻嘻：流程設計做好，TPT也能少卡關。

Interventions to reduce the impact of post-tuberculosis lung disease: a scoping review of the literature¶

Authors: Byrne AL et al. | Journal: BMC Pulm Med | Date: 2026 Jun 04
DOI: 10.1186/s12890-026-04355-3
TL;DR: scoping review納入87項PTLD介入研究，多數小型且非以PTLD為主要目標；corticosteroids、部分HDT、doxycycline、metformin與inhaled bronchodilators僅呈不一致或初步效益訊號。

不嘻嘻：PTLD研究很多，答案還是很害羞。

Global burden of drug-resistant tuberculosis in children: A systematic analysis for the Global Burden of Disease Study¶

Authors: Liu X et al. | Journal: Eur Respir J | Date: 2026 Jun 04
DOI: 10.1183/13993003.01648-2025
TL;DR: GBD 2021估計2021年全球兒童MDR/RR-TB 32,515例、死亡5,887例，XDR-TB 1,193例、死亡253例；女性、幼齡、低SDI與HIV共感染兒童負擔較重。

不嘻嘻：兒童MDR/RR-TB完全不是小問題。

Incidence, risk factors and management of paradoxical reaction in central nervous system tuberculosis in the United Kingdom¶

Authors: Carter EC et al. | Journal: J Infect | Date: 2026 Jun 03
DOI: 10.1016/j.jinf.2026.106778
TL;DR: 英國20院229名非HIV CNS TB成人中，21%發生paradoxical reaction，與disability、住院延長、neurosurgical intervention相關；風險因子含CSF M. tuberculosis陽性、重症與CSF neutrophils較高。

不嘻嘻：CNS TB反轉劇，通常不是好消息。

🟢 One Health / Zoonoses¶

Agricultural fungicides shape soil and sediment reservoirs of multidrug-resistant fungi¶

Authors: Qin Z et al. | Journal: Nat Commun | Date: 2026 Jun 04
DOI: 10.1038/s41467-026-73958-5
TL;DR: 農業土壤與河川沉積物中>3,900株fungicide-resistant fungi含358株MDR；triazole exposure上調virulence genes與mycotoxin clusters，顯示農業環境可能成為臨床antifungal resistance儲存庫。

不嘻嘻：農業fungicide也在幫MDR練等。

The mouse-lethal H5N1 influenza virus carrying the PB2-384L/443R/460M characteristics acquired in avian hosts can effectively utilize human ANP32A/B proteins¶

Authors: Lin W et al. | Journal: Emerg Microbes Infect | Date: 2026 Jun 05
DOI: 10.1080/22221751.2026.2685917
TL;DR: H5N1 PB2-384L/443R/460M可在缺乏PB2-627K或701N下提升mouse lethality，並有效利用human ANP32A/B、增強vRNP互動與assembly，提示禽源演化已具zoonotic風險。

不嘻嘻：H5N1適應哺乳類的劇情太不浪漫。

A new clade of H9N2 avian influenza virus circulating in Laos¶

Authors: Li J et al. | Journal: Emerg Microbes Infect | Date: 2026 Dec
DOI: 10.1080/22221751.2026.2678641
TL;DR: 寮國2024年定序52株H9N2，發現BJ/94-like lineage新HA clade 4.6.20，與既有clades抗原反應低；全株帶HA-L226與NP-N52，需持續監測與更新疫苗株。

不嘻嘻：H9N2又換外套，疫苗追得很喘。

Metagenomic and serological evidence of emerging tick-borne viruses in livestock, humans, and rats in Pakistan¶

Authors: Ammar M et al. | Journal: Virol Sin | Date: 2026 Jun 03
DOI: 10.1016/j.virs.2026.06.001
TL;DR: 巴基斯坦87隻livestock-associated ticks RNA sequencing發現至少31種病毒；319 livestock、253 humans、214 rats血清調查顯示JMTV等跨物種暴露，且JMTV neutralizing antibodies證實productive infection。

不嘻嘻：tick-borne viruses的名單又變厚了。

Host Ecology Shapes Gut Pathogen Evolution: An Eco-Evolutionary Trade-Off in Plateau Wildlife¶

Authors: Wang Y et al. | Journal: Environ Microbiol | Date: 2026 Jun
DOI: 10.1111/1462-2920.70344
TL;DR: 青藏高原zokor與pika兩年半metagenomics顯示宿主niche塑造gut pathogens、VFGs與PHI genes；zokor豐度與network較高，pika diversity較高但定殖較opportunistic。

嘻嘻：host ecology把pathogen演化寫得很立體。

Emergence of Marburg virus disease in Ethiopia: Implications for public health preparedness and its impact on Ethiopia's health system¶

Authors: Biadgilign S et al. | Journal: PLoS Negl Trop Dis | Date: 2026 Jun
DOI: 10.1371/journal.pntd.0014394
TL;DR: 衣索比亞2025年11月首度確認MVD，截至2026-01-25共19例、14死，857名contacts完成21天追蹤；疫情暴露監測、跨境傳播與醫療體系韌性挑戰。

不嘻嘻：Marburg一出場，公衛壓力直接拉滿。

Authors: Bajwa HUR et al. | Journal: PLoS One | Date: 2026
DOI: 10.1371/journal.pone.0344889
TL;DR: 美國2009–2022年177起跨州動物接觸NTS outbreaks涉及40個serovars；random forest指向鳥類、爬蟲類、農業飼料店與住宅為關鍵暴露來源與場域。

不嘻嘻：動物接觸outbreak，家門口也很會藏雷。

A first insight into the diversity of pathogenic Leptospira serogroups in human cases from Ecuador¶

Authors: Jaramillo NM et al. | Journal: Acta Trop | Date: 2026 Jun 03
DOI: 10.1016/j.actatropica.2026.108169
TL;DR: 厄瓜多371名疑似leptospirosis發燒患者中121例MAT陽性，檢出14種Leptospira serogroups；Bataviae、Sejroe、Grippotyphosa最常見，與當地動物reservoirs高度重疊。

嘻嘻：Leptospira地圖越細，防治越有方向。

Longitudinal Assessment of Psychological Distress and Coping Strategies in Animal Bite Victims Undergoing Rabies Post-Exposure Prophylaxis¶

Authors: Singh AD et al. | Journal: Am J Trop Med Hyg | Date: 2026 Jun 04
DOI: 10.4269/ajtmh.26-0114
TL;DR: 北印度100名接受rabies PEP的動物咬傷者，day 0到28的IES-R與DASS-21 distress顯著下降；Category III嚴重咬傷、年齡與社經狀態影響anxiety與coping。

嘻嘻：rabies PEP也需要照顧心理創傷。

Beyond brain fog: viral proteins as convergent drivers of neuroinflammation and proteinopathy¶

Authors: Käufer C et al. | Journal: Curr Opin Virol | Date: 2026 Jun 05
DOI: 10.1016/j.coviro.2026.101559
TL;DR: post-viral neurological syndromes可能由shed viral proteins驅動，而非CNS大量複製；多種病毒蛋白收斂活化glial TLR4/TLR2與破壞proteostasis，形成neuroinflammation與proteinopathy。

不嘻嘻：post-viral腦霧可能比想像更黏人。

Integrative phenotypic and functional genomic characterization of virulence and antimicrobial resistance in Salmonella enterica isolates from reptiles¶

Authors: Satharasinghe DA et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1841627
TL;DR: 佛羅里達爬蟲類Salmonella culture陽性率16.41%，24株S. enterica中58.3%為MDR，WGS檢出55個AMR genes與239個VF genes，支持爬蟲為mobile genetic elements儲存庫。

不嘻嘻：爬蟲身上的Salmonella很有武裝感。

Seasonal surveillance of Salmonella prevalence, antimicrobial resistance, and genetic relatedness in chickens from slaughterhouses and retail markets in Northeast Thailand¶

Authors: Zhang Z et al. | Journal: Vet World | Date: 2026 Apr
DOI: 10.14202/vetworld.2026.1550-1563
TL;DR: 泰國東北689份雞肉供應鏈樣本中，Salmonella盛行率32.37%，零售市場與雨季風險較高；MDR占32.43%，冬季最高，PFGE顯示同地同季株具clonal relatedness。

不嘻嘻：雞肉供應鏈裡Salmonella仍很忙。

🟡 Food Security / Food Safety¶

An ultrasensitive Fiber ring laser platform for detection of trace-level Enrofloxacin with a functionalized microfiber sensitized by COF-V@ENR apt/DA film¶

Authors: Guo S et al. | Journal: Food Chem | Date: 2026 Jun 01
DOI: 10.1016/j.foodchem.2026.149902
TL;DR: COF-V@ENR Apt/DA fiber ring laser可偵測0.01–100 nM enrofloxacin，LOD 0.009 nM；Gradient Boosting驗證R² 0.9970，具食品安全與環境監測潛力。

嘻嘻：食安檢測靈敏到enrofloxacin難躲。

The GA-optimized MSPE measurement for high-performance electrochemical detection of bacterial pathogens in complex matrices¶

Authors: Zhang X et al. | Journal: Food Chem | Date: 2026 Jun 02
DOI: 10.1016/j.foodchem.2026.149904
TL;DR: GA-optimized MSPE結合aptamer magnetic probes、XGBoost與electrochemical detection，可在複雜食品matrix中進行跨species、跨matrix的foodborne bacterial pathogens偵測並降低matrix interference。

嘻嘻：複雜食品matrix終於少一點干擾。

Food system drivers of global foodborne bacterial disease burden: Pathogen-specific attribution using 1990-2021 GBD 2021 and FAO food system databases, with implications for food safety control¶

Authors: Zhou Z et al. | Journal: Int J Food Microbiol | Date: 2026 Jun 01
DOI: 10.1016/j.ijfoodmicro.2026.111883
TL;DR: GBD 2021估計2021年foodborne bacterial pathogens造成364,500 diarrheal deaths與2,461萬DALYs，負擔78.7%集中撒哈拉以南非洲與南亞；food safety infrastructure比產量更關鍵。

不嘻嘻：foodborne disease負擔仍然很不平均。

Application of AI-facilitated handwashing monitoring system on food handlers¶

Authors: Guo Y et al. | Journal: Sci Rep | Date: 2026 Jun 04
DOI: 10.1038/s41598-026-56516-3
TL;DR: 46名大學餐廳food handlers兩次field study顯示，AI computer-vision導引洗手較ad-hoc洗手更能降低VRBGA Enterobacteriaceae；受試者接受度高，適合即時提醒技巧與時間。

嘻嘻：AI盯洗手，尷尬但可能真的有用。

Measurement, regional disparities, and dynamic evolution of food crop breeding technology innovation in China¶

Authors: Shen J et al. | Journal: Sci Rep | Date: 2026 Jun 04
DOI: 10.1038/s41598-026-56288-w
TL;DR: 中國31省2013–2023年food crop breeding innovation上升但區域差距仍明顯；主要銷售區優於生產區，spatial Markov顯示高水準鄰近地區可提升向上流動機率。

不嘻嘻：農業創新進步了，落差也沒消失。

Recent advances and critical insights of cellulose nanocrystals in active food packaging¶

Authors: Gong X et al. | Journal: Crit Rev Food Sci Nutr | Date: 2026 Jun 05
DOI: 10.1080/10408398.2026.2681137
TL;DR: CNC-based active food packaging可改善mechanical與gas-barrier表現，並作為Pickering emulsion stabilizers與active compounds carriers；仍需interfacial engineering與標準化regulatory safety evaluation。

嘻嘻：active packaging看來能更聰明一點。

From Harvest to Health: A Systems-Based Evaluation of FarmsSHARE's Impact on Nutrition in North Carolina¶

Authors: Hege A et al. | Journal: J Hum Nutr Diet | Date: 2026 Jun
DOI: 10.1111/jhn.70286
TL;DR: 北卡FarmsSHARE 2024年支付312個農場295萬美元，322份survey與14場focus groups顯示92% recipients健康食物取得改善、95%使用全部或多數品項。

嘻嘻：食物取得改善，比口號更有營養。

Occurrence of acrylamide and 4-methylimidazole in roasted and ground coffee and the effect of L-asparaginase treatment of green coffee on their levels¶

Authors: da Costa DS et al. | Journal: Food Addit Contam Part A Chem Anal Control Expo Risk Assess | Date: 2026 Jun 05
DOI: 10.1080/19440049.2026.2683670
TL;DR: 巴西48款烘焙研磨咖啡acrylamide <LOD–207.3 µg/kg、4-MEI <LOD–366.1 µg/kg；L-asparaginase預處理使asparagine降23.8–34.1%、acrylamide降30.4–41.4%，不影響4-MEI。

嘻嘻：咖啡少點acrylamide，早晨更安心。

Assessment of dietary patterns and macronutrient intake among the adult population of Armenia¶

Authors: Pipoyan D et al. | Journal: Front Nutr | Date: 2026
DOI: 10.3389/fnut.2026.1840868
TL;DR: 亞美尼亞1,400名成人個人飲食資料顯示，日均熱量1,738 kcal，protein 71.51 g、carbohydrates 209.57 g、fat 69.91 g；飲食高度依賴麵包與麵粉製品。

不嘻嘻：飲食太靠麵包，營養彈性就受限。

Preliminary hematological reference values and morphology of blood cells in farmed sex-reversed male Nile tilapia (Oreochromis niloticus) from Southern Thailand¶

Authors: Swangneat K et al. | Journal: Vet World | Date: 2026 Apr
DOI: 10.14202/vetworld.2026.1773-1784
TL;DR: 泰國南部46尾養殖sex-reversed male Nile tilapia僅14份高品質血樣納入，建立PCV 0.23–0.45 L/L、Hb 76–119 g/L等初步hematological reference values。

嘻嘻：tilapia血液參考值終於有雛形。

Wastewater-based Surveillance of Salmonella Senftenberg as an Early-warning Indicator for Foodborne Outbreaks - Lianyungang City, Jiangsu Province, China, 2023-2025¶

Authors: Zhu X et al. | Journal: China CDC Wkly | Date: 2025 Dec 19
DOI: 10.46234/ccdcw2025.268
TL;DR: 中國江蘇連雲港wastewater surveillance以cgSNP確認ST14 S. Senftenberg與foodborne outbreak clonal一致；相關菌株早於outbreak 7–14天出現並持續逾3週。

嘻嘻：wastewater提早示警，食安多一雙眼。

資料來源：PubMed (articles retrieved 2026-06-06)