Daily Journal Digest — 2026-06-04¶

過去 24 小時新增：Transplant ID × 16、One Health × 11、Food Security × 14，共 41 篇。

🔴 Transplant & Opportunistic Infections¶

Wickerhamomyces anomalus Fungemia during Healthcare-Associated Outbreak, Pereira, Colombia, 2025¶

Authors: Ordoñez KM et al. | Journal: Emerg Infect Dis | Date: 2026 Jun
DOI: 10.3201/eid3206.251980
TL;DR: 哥倫比亞佩雷拉2025年healthcare-associated outbreak共10例Wickerhamomyces anomalus bloodstream infection，9例為兒童、8例新生兒；6株STR顯示clonal transmission，所有病人存活。

嘻嘻：clonal outbreak還全員存活，今天先小聲加薪給感控。

Authors: Albanell-Fernández M et al. | Journal: Int J Infect Dis | Date: 2026 Jun 01
DOI: 10.1016/j.ijid.2026.108847
TL;DR: 407例candidemia中，TTP可預測catheter-related來源：C. albicans ≤27小時OR 5.1、C. parapsilosis ≤35小時OR 3.1，表現優於DTP。

嘻嘻：blood culture時鐘也會抓source，微生物室又帥一次。

Post-Transplantation Hairy Cell Leukemia with Hemophagocytic Lymphohistiocytosis in an Adult Kidney Transplant Recipient: A Case of Rare Occurrence¶

Authors: Ghazizadeh M et al. | Journal: Iran J Kidney Dis | Date: 2025 Sep 27
PMID: 42234896
TL;DR: 腎臟移植成人發生late-onset EBV-positive hairy cell leukemia合併HLH，臨床可類似sepsis；HLH與PTLD同時出現極罕見，診斷與處置困難。

不嘻嘻：transplant後連診斷都玩變裝秀，值班醫師先跪。

Indolent Localized Orbital Aspergillosis Mimicking Breast Cancer Metastasis¶

Authors: Wu X et al. | Journal: Ophthalmology | Date: 2026 Jun 03
DOI: 10.1016/j.ophtha.2026.05.004

Helminth seropositivity in allergic bronchopulmonary aspergillosis: Co-exposure, misdiagnosis, or cross-reactivity?¶

Authors: Mewara A et al. | Journal: Trop Doct | Date: 2026 Jun 03
DOI: 10.1177/00494755261456517
TL;DR: ABPA與helminth infections有相似clinical與immunologic特徵；回溯cross-sectional資料提示，helminth-endemic地區ABPA若反應不全或表現 atypical，應評估寄生蟲暴露。

不嘻嘻：ABPA遇到helminth，免疫反應開始玩你猜我猜。

Proportions of M. Intracellulare and M. Avium among non-tuberculous mycobacteria isolates in China: A Systematic review and Meta-Analysis¶

Authors: Hou Y et al. | Journal: J Clin Tuberc Other Mycobact Dis | Date: 2026 Aug
DOI: 10.1016/j.jctube.2026.100600
TL;DR: 中國190項研究顯示NTM isolates中M. intracellulare占39.30%、M. avium占13.18%；HIV陽性者反轉為M. avium較常見39.46%，異質性I2>95%。

不嘻嘻：NTM版圖又亂又異質，統合分析也只能苦笑。

Are CD4+ T-Cell Counts Associated with Pneumocystis jirovecii Detection in Hospitalized Patients with Liver Disease? A Retrospective Exploratory Pilot Analysis¶

Authors: Katsounas A et al. | Journal: Livers | Date: 2026 Jun
DOI: 10.3390/livers6030040
TL;DR: 455名肝病住院者院內死亡率22.6%；22名immunological risk病人中8人做P. jirovecii PCR、3人陽性，但0例死於PJ pneumonia，死亡主因為hepatic decompensation與bacterial infections。

不嘻嘻：肝病住院者問題很多，P. jirovecii倒像配角。

Fourth-generation chemiluminescence QuantiFERON-TB Plus assay versus T-SPOT.TB semi-automated assay: a case for the use of both assays in immunosuppressed patients¶

Authors: Palacios-Penedo S et al. | Journal: ERJ Open Res | Date: 2026 May
DOI: 10.1183/23120541.01257-2025
TL;DR: 3748名immunosuppressed病人中，任一IGRA陽性13.4%、不確定結果2%上下；QFT-Plus CLIA與T-SPOT.TB整體一致率93.0%，但HIV等族群discordance較高。

嘻嘻：IGRA雙軌並行，immunosuppressed族群少一點盲猜。

Comparative proteome analyses of human natural killer cells from patients after allogeneic stem cell transplantation and healthy individuals challenged with Aspergillus fumigatus¶

Authors: Springer J et al. | Journal: Microlife | Date: 2026
DOI: 10.1093/femsml/uqag020
TL;DR: alloSCT後NK cells面對Aspergillus fumigatus刺激，day 90有1652個proteins差異、day 180降至77個；STAT1-IL27RA與GZMA、IFNg、NCAM1軸可能參與反應。

嘻嘻：NK cells術後慢慢回神，proteome把過程拍給你看。

Community-based health screening and all-cause mortality in rural South Africa: a longitudinal cohort study¶

Authors: Magut F et al. | Journal: BMJ Public Health | Date: 2026
DOI: 10.1136/bmjph-2025-003803
TL;DR: 南非夸祖魯-納塔爾農村18041人參與Vukuzazi health fair，追蹤中位4.0年；參與者all-cause mortality hazard降25%（HR 0.75），5年絕對死亡率降1.5%。

嘻嘻：community screening有救命感，公共衛生今天很有面子。

Lead Optimization of TgCDPK1 Inhibitors for the Treatment of Toxoplasmosis¶

Authors: Mannino MP et al. | Journal: J Med Chem | Date: 2026 Jun 03
DOI: 10.1021/acs.jmedchem.6c00065
TL;DR: 以X-ray structure-based design開發Toxoplasma gondii TgCDPK1 inhibitors，多個化合物具良好oral bioavailability、brain exposure與24小時PK；16c在急性感染小鼠最具preclinical潛力。

嘻嘻：toxoplasmosis新藥苗頭不錯，腦部曝露聽起來很香。

Common and Rare Emerging and Re-Emerging Infectious Diseases in Pediatric Transplant Recipients: A Comprehensive Review¶

Authors: Verma A | Journal: Pediatr Transplant | Date: 2026 Jun
DOI: 10.1111/petr.70365
TL;DR: pediatric transplant recipients除CMV、EBV與bacterial bloodstream infections外，SARS-CoV-2、MDR bacteria/fungi、measles、pertussis與arboviruses等emerging pathogens負擔上升。

不嘻嘻：pediatric transplant名單越看越長，疫苗牆也要補滿。

Virologic and Immunological Failure and Associated Factors Among Adults Living With HIV on HAART at Jimma Medical Center, Southwest Ethiopia¶

Authors: Teshome RT et al. | Journal: J Int Assoc Provid AIDS Care | Date: 2026
DOI: 10.1177/23259582261453642
TL;DR: 衣索比亞272名HIV成人接受HAART中，immunologic failure 8.1%、virologic failure 10.3%；poor adherence與tuberculosis co-infection或baseline viral load ≥1000 copies/mL相關。

不嘻嘻：HIV治療失敗多半不新奇，但每次都很扎心。

Real-world experience with gilteritinib maintenance following allogeneic transplantation in relapsed/refractory AML patients harboring FLT3 mutations¶

Authors: Lin YT et al. | Journal: Blood Res | Date: 2026 Jun 03
DOI: 10.1007/s44313-026-00144-3
TL;DR: 亞洲FLT3-mutated R/R AML cohort中，gilteritinib術前salvage後接allo-HSCT與maintenance，CR率76.2%；追蹤46.2個月，maintenance與較低1年relapse及較佳生存相關。

嘻嘻：gilteritinib接棒maintenance，AML賽後防守有亮點。

Long-term spectrum and outcomes of post-transplant malignancy following liver transplantation: A comprehensive single-center study¶

Authors: Megaly MG et al. | Journal: Surg Oncol | Date: 2026 May 28
DOI: 10.1016/j.suronc.2026.102457
TL;DR: 1841名成人肝臟移植者追蹤中位10.6年，25年non-HCC solid organ malignancy 18%、skin malignancy 29%、PTLD 4%；malignancy占死因20%，僅次於infection 23%。

不嘻嘻：liver transplant活久了，malignancy也來收長期帳。

Authors: Tashiro M et al. | Journal: Respir Investig | Date: 2026 Jun 02
DOI: 10.1016/j.resinv.2026.101458
TL;DR: 日本azole-resistant Aspergillus fumigatus呈異質分布，區域監測55株中7株resistant；CPA cohort isolate-based resistance 8.3%，azole-treatment failure subgroup達46.2%。

不嘻嘻：azole-resistant Aspergillus不均勻冒出，治療又要抖。

🟢 One Health / Zoonoses¶

Yellow Fever Virus Surveillance in Callithrix spp. Marmosets during Epizootic Outbreak, Brazil, 2024-2025¶

Authors: Siconelli MJL et al. | Journal: Emerg Infect Dis | Date: 2026 Jun
DOI: 10.3201/eid3206.251388
TL;DR: 巴西聖保羅州2024–2025年epizootic outbreak期間，9隻Callithrix penicillata marmosets檢出YFV，高viral load且有典型器官病灶，支持納入multispecies surveillance。

不嘻嘻：YFV監測連marmosets都上工，人類真的別裝沒事。

Assessing Evidence to Guide Primary Prevention of Pathogen X¶

Authors: Holmes I et al. | Journal: Emerg Infect Dis | Date: 2026 Jun
DOI: 10.3201/eid3206.260293
TL;DR: Pathogen X primary prevention可借鏡常見但人傳人差的zoonotic viruses spillover證據；在pandemic events稀少下，precautionary approach是較可行的empirical foundation。

嘻嘻：Pathogen X還沒登場，prevention劇本先寫起來。

In Vitro Antifungal Drug Susceptibility of Feline Sporothrix schenckii Complex Isolates, Thailand, 2023-2025¶

Authors: Yurayart C et al. | Journal: Emerg Infect Dis | Date: 2026 Jun
DOI: 10.3201/eid3206.260135
TL;DR: 泰國2023–2025年1178株貓Sporothrix schenckii complex isolates中，687株對itraconazole reduced susceptibility，含321株single-drug、270株co-reduced、96株multidrug-reduced。

不嘻嘻：貓源Sporothrix對itraconazole冷感，毛孩也讓ID焦慮。

Cerebrospinal Fluid Findings among Patients with Anaplasmosis and Central Nervous Involvement, Minnesota and Wisconsin, USA¶

Authors: Dumic I et al. | Journal: Emerg Infect Dis | Date: 2026 Jun
DOI: 10.3201/eid3206.260240
TL;DR: 美國明尼蘇達與威斯康辛10名anaplasmosis合併CNS症狀住院者，5人CSF正常、4人mild lymphocytic pleocytosis；CSF異常與嚴重度不相關，皆對doxycycline快速改善。

嘻嘻：CNS anaplasmosis看似嚇人，doxycycline還是很罩。

Regional heterogeneity of spatial-temporal characteristics and meteorological-environmental driving factors of hemorrhagic fever with renal syndrome in China¶

Authors: Cheng C et al. | Journal: One Health | Date: 2026 Jun
DOI: 10.1016/j.onehlt.2026.101454
TL;DR: 中國2005–2022年HFRS呈秋冬與春季雙峰；monthly mean temperature 7.5°C時RR 1.85、relative humidity 38%時RR 1.21，風險受host與環境區域異質性驅動。

不嘻嘻：HFRS跟天氣一起起伏，老鼠與環境都不放假。

CEIRR Risk Assessment Pipeline executive reports on H5N1 highly pathogenic avian influenza 2.3.4.4b, swine H1 1B.2, and H9N2 low pathogenicity avian influenza B4.7.2¶

Authors: | Journal: J Virol | Date: 2026 Jun 03
DOI: 10.1128/jvi.00545-26
TL;DR: CEIRR RAP整合六中心surveillance、phenotypic analysis與computational modeling，評估H5N1 2.3.4.4b、swine H1 1B.2與H9N2 B4.7.2之pandemic potential。

嘻嘻：influenza風險評估變成流水線，pandemic焦慮稍微有工具。

AMR in wild animals and plants: global trends and future priorities in wildlife-associated antimicrobial resistance research¶

Authors: Tipper HJ et al. | Journal: NPJ Antimicrob Resist | Date: 2026 Jun 02
DOI: 10.1038/s44259-026-00226-3
TL;DR: 866篇wildlife-associated AMR研究顯示明顯taxonomic與geographic偏差，mammals與birds占多數，plants僅14篇、amphibians 10篇；resistant fungi僅2%，Escherichia占microbial targets 33%。

不嘻嘻：wildlife AMR研究偏到不行，One Health還在補地圖。

Metagenomic profiling reveals shared resistome signatures between humans and pigs in Vietnamese smallholder farms¶

Authors: Linh LTK et al. | Journal: NPJ Antimicrob Resist | Date: 2026 Jun 02
DOI: 10.1038/s44259-026-00223-6
TL;DR: 越南50個小農場 paired fecal metagenomics檢出10270個ARGs、550型；人與豬共享52% ARGs，含mcr、blaOXA-58、optrA，並見近緣E. coli strains共享。

不嘻嘻：人豬共享resistome，小農場的ARGs很會串門子。

Age-driven shifts of the camel gut microbiome and resistome in extensively reared dromedary camels¶

Authors: Wang W et al. | Journal: Microbiol Spectr | Date: 2026 Jun 03
DOI: 10.1128/spectrum.03183-25
TL;DR: 未記錄therapeutic antibiotic暴露的dromedary camels中，6月齡幼駱駝gut microbiome較不穩且ARGs較多；6歲成駱駝ARG richness與diversity較低，resistome隨年齡收斂。

嘻嘻：camel resistome會隨年齡收斂，至少不是一路放飛。

Polyunsaturated fatty acid and oxylipin profiles of Angiostrongylus cantonensis during cerebral-to-pulmonary migration illuminate parasite and host microenvironmental lipid signatures¶

Authors: Tang Z et al. | Journal: Parasit Vectors | Date: 2026 Jun 02
DOI: 10.1186/s13071-026-07469-z
TL;DR: Angiostrongylus cantonensis缺乏Δ6 desaturase與canonical COX/LOX/CYP；L5自腦移行至肺時累積n-6 PUFAs與anti-inflammatory oxylipins，反映host microenvironment差異。

嘻嘻：寄生蟲lipid路線圖展開，host環境被看得更清楚。

Antimicrobial resistance in Enterobacteriaceae across the human-animal-environment interface at the lower catchment area of Akaki River, Ethiopia¶

Authors: Weldo BF et al. | Journal: One Health Outlook | Date: 2026 Jun 02
DOI: 10.1186/s42522-026-00220-9
TL;DR: 衣索比亞Akaki River下游720件human-animal-water samples分離1042株Enterobacteriaceae，MDR占62.7%，水樣最高且見Ertapenem resistance，凸顯One Health surveillance需求。

不嘻嘻：河水也成AMR倉庫，One Health不是口號是欠債。

🟡 Food Security / Food Safety¶

Exploring the biochemical and biological functions of copper radical oxidases in the vascular wilt phytopathogen Verticillium dahliae¶

Authors: Fong JK et al. | Journal: Appl Environ Microbiol | Date: 2026 Jun 03
DOI: 10.1128/aem.00790-26
TL;DR: Verticillium dahliae JR2中AA5_2主要呈aryl-alcohol oxidase活性、AA5_1呈aldehyde oxidase活性；knockout未支持其直接參與phytopathogenesis，與foliar phytopathogens機制不同。

嘻嘻：phytopathogen enzyme拆清楚，負結果也能省大家時間。

Apigenin decreases the pathogenicity of Aeromonas hydrophila infection by inhibiting aerolysin activity and interfering with quorum sensing¶

Authors: Li S et al. | Journal: J Appl Microbiol | Date: 2026 Jun 03
DOI: 10.1093/jambio/lxag131
TL;DR: apigenin在低於MIC濃度抑制Aeromonas hydrophila AerA與QS-regulated virulence factors，結合Pro347/Pro395並降低channel catfish challenge死亡率，支持anti-virulence策略。

嘻嘻：anti-virulence策略有戲，不殺菌也能讓病原變乖。

Research on an improved RT-DETR-based model for rice disease detection¶

Authors: Zhang Y et al. | Journal: PLoS One | Date: 2026
DOI: 10.1371/journal.pone.0349237
TL;DR: ECL-RTDETR用EfficientViT、CARAFE與LDConv改善rice disease detection；相較RT-DETR，mAP@0.5增0.7%、速度增22.2 FPS，GFLOPs降81.8、參數減22.12M。

嘻嘻：rice disease AI又快又瘦，田間偵測更像能落地。

Effect of plastic composition in the combustion material on the Persistent Organic Pollutant content in smoked chicken meat¶

Authors: Hoang GD et al. | Journal: PLoS One | Date: 2026
DOI: 10.1371/journal.pone.0350345
TL;DR: 越南smoked chicken實驗顯示塑膠混入燃料使POPs上升，污染梯度為wood<PE<PS<PVC；PVC造成12種PCDD/Fs、21種PCBs與多種carcinogenic PAHs，組間差異p<0.01。

不嘻嘻：拿塑膠燻雞，這食品安全劇情真的自己寫悲劇。

Sentinel Surveillance-Based Epidemiological Analysis of Foodborne Diseases in Shengsi County, China, 2019-2024¶

Authors: Chen J et al. | Journal: Infect Drug Resist | Date: 2026
DOI: 10.2147/IDR.S594651
TL;DR: 中國浙江嵊泗2019–2024年2173例FBD中，夏季占38.93%、家庭場域76.44%、海產相關34.74%；V. parahaemolyticus持續endemic，2024年Salmonella陽性升至9.32%。

不嘻嘻：海產加夏天老組合，foodborne disease永遠準時打卡。

Two decades of human- and climate-induced groundwater storage shifts in Brazil¶

Authors: Getirana A et al. | Journal: Sci Adv | Date: 2026 Jun 05
DOI: 10.1126/sciadv.aee0266
TL;DR: 巴西2002–2023年aquifer outcrop zones平均groundwater recharge為223±16 mm/year，約占降雨12%、總通量1900±136 km3/year；東部過度開採區出現持續depletion或無recharge。

不嘻嘻：groundwater被抽到透支，氣候帳本也開始催收。

Integrated study of sediments and fish from Croatian rivers: potentially toxic elements and human health concerns¶

Authors: Miličić L et al. | Journal: Environ Geochem Health | Date: 2026 Jun 03
DOI: 10.1007/s10653-026-03270-0
TL;DR: 克羅埃西亞河川sediments多數PTEs低於指引，但Cd常超標且為主要ecological risk；魚體Pb與Cr構成food safety concern，HI>1、CR>1×10^-6提示不宜長期無管制食用。

不嘻嘻：河魚重金屬超標，長期吃下去真的不太妙。

Enterobacteriaceae contamination in raw chicken meat from Amazonas, Brazil: implications for food hygiene¶

Authors: Amorim ABA et al. | Journal: Braz J Biol | Date: 2026
DOI: 10.1590/1519-6984.305490
TL;DR: 巴西亞馬遜Manaus 88件raw chicken meat中，Salmonella spp. 32.9%、E. coli 42.0%、其他Enterobacteriaceae 11.4%；室溫販售與街市污染較高，冷鏈與衛生缺失明顯。

不嘻嘻：raw chicken冷鏈破功，Salmonella直接出來開會。

Classification of food security status in disaster-prone areas: a comparative analysis of machine learning models using Support Vector Machine, Random Forest, and Logistic Regression¶

Authors: Sukmawani R et al. | Journal: Braz J Biol | Date: 2026
DOI: 10.1590/1519-6984.305154
TL;DR: 災害易發區food security status分類中，SVM表現最佳，accuracy 92–96%、precision 0.93、recall 0.94、F1 0.93；錯誤多集中於FSI約1的threshold邊界案例。

嘻嘻：food security分類準度不錯，災區決策多一把尺。

Evaluation of land suitability and potential production of sorghum (Sorghum bicolor L.) as a biomass energy crop in West Sumatra, Indonesia¶

Authors: Juniarti et al. | Journal: Braz J Biol | Date: 2026
DOI: 10.1590/1519-6984.297938
TL;DR: 印尼西蘇門答臘sorghum land suitability為S1，適合25–27°C、降雨<200 mm、濕度<75%、土深>60 cm與pH 4.4–6.1；actual production potential估5 t/ha。

嘻嘻：sorghum適地評估清楚，bioenergy至少先有地圖。

Effects of combinatorial hurdles on a non-alcoholic beer matrix challenged with Salmonella Javiana, Escherichia coli, Listeria monocytogenes, Pseudomonas aeruginosa, and Bacillus cereus¶

Authors: Maust A et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1835393
TL;DR: non-alcoholic beer matrix中，pH是pathogen control關鍵；1.50 volumes CO2可控制Salmonella Javiana與E. coli，多種處理使菌量降至<10 CFU/mL、>3 log reduction。

嘻嘻：non-alcoholic beer也能控菌，pH這次很有存在感。

The SPI-6 T6SS gene cluster from Salmonella Tennessee encodes a new antibacterial nuclease effector protein¶

Authors: Vargas-Del Río C et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1794835
TL;DR: Salmonella Tennessee SPI-6 T6SS具antibacterial activity；VR3中新E/I module之RhsA-HNHc造成E. coli growth inhibition，immunity protein可完全救回，並證實DNase activity。

嘻嘻：Salmonella T6SS新武器曝光，細菌內戰真精彩。

Advanced biosensing strategies for high-risk foodborne pathogens: a comprehensive review of Salmonella and Listeria monocytogenes¶

Authors: Gumush SE et al. | Journal: Food Chem (Oxf) | Date: 2026 Jun
DOI: 10.1016/j.fochms.2026.100417
TL;DR: 此review聚焦Listeria monocytogenes與Salmonella spp. biosensors，整合bioreceptor、transducer與AI-driven design，並評估scalability、portability與食品產業routine use可行性。

嘻嘻：biosensor加AI，食品病原檢測越來越像現場可用。

Detection of viable and VBNC Salmonella in retail meat using optimized PMAxx real-time PCR¶

Authors: Pham HT et al. | Journal: J Microbiol Methods | Date: 2026 Jun 01
DOI: 10.1016/j.mimet.2026.107568
TL;DR: PMAxx real-time PCR可去除10^8 CFU/mL死菌訊號，18小時pre-enrichment後LOD為10 CFU/g；33件零售肉品23件陽性，與ISO 6579-1:2017 culture 100%一致。

嘻嘻：VBNC Salmonella也抓得到，PCR這次很懂食品現場。

資料來源：PubMed (articles retrieved 2026-06-04)