Daily Journal Digest — 2026-06-03¶
過去 24 小時新增：Transplant ID × 10、One Health × 10、Food Security × 10，共 30 篇。
🔴 Transplant & Opportunistic Infections¶
Experiences and understanding of diagnosis and treatment among drug-resistant extrapulmonary tuberculosis patients: A qualitative study from Central India¶
Authors: Bhagwat G et al. | Journal: PLOS Glob Public Health | Date: 2026
DOI: 10.1371/journal.pgph.0006383
TL;DR: 印度18名 drug-resistant EPTB 患者訪談顯示，照護歷程充滿不確定性：疾病與 drug resistance 認知不足、診斷延遲、治療副作用與溝通不足，並伴隨財務壓力與 stigma。
不嘻嘻：TB 照護像迷宮，病人還得自備導航。
Pediatric candidemia epidemiology and antifungal susceptibility profiles reported by the ISPED program in China, 2016-2024¶
Authors: Xu J et al. | Journal: Antimicrob Agents Chemother | Date: 2026 Jun 02
DOI: 10.1128/aac.00031-26
TL;DR: 中國13家兒童醫院527例 pediatric candidemia 中，NACs占74.0%；C. parapsilosis 2019至2024由21.2%升至51.9%，且 fluconazole susceptibility 2022–2024降至63.6%。
不嘻嘻：Candida 又換打法，兒科病房先冒冷汗。
Change in plasma cryptococcal antigen titers in Uganda among outpatients with advanced HIV disease from 2017 to 2022 with rollout of national cryptococcal screening¶
Authors: Poeschla A et al. | Journal: PLoS One | Date: 2026
DOI: 10.1371/journal.pone.0349854
TL;DR: 烏干達436名 advanced HIV disease 且 CrAg 陽性成人中，2017–2022年 plasma CrAg titer 未下降；2022年58%從未使用 ART，顯示 late presentation 仍持續。
不嘻嘻：screening 有了，late presentation 還是很會遲到。
Optimizing Pneumocystis jirovecii Prophylaxis in Immunocompromised Patients: Defining the Clinical Role of Atovaquone¶
Authors: Pham TN et al. | Journal: Transpl Infect Dis | Date: 2026 Jun 02
DOI: 10.1111/tid.70255
TL;DR: 2015–2022年149名使用 atovaquone 進行 PJP prophylaxis 患者中，2020後占84%，使用時間由2.3延至6.0個月；67人改藥後多數回到 cotrimoxazole，無 breakthrough PJP。
嘻嘻：atovaquone 當備援，至少沒有 PJP 破門。
Pneumocystis jirovecii Infection in children with solid tumors: Incidence and clinical characteristics in a retrospective cohort (2010-2023)¶
Authors: Vera García JM et al. | Journal: Arch Argent Pediatr | Date: 2026 Jun 04
DOI: 10.5546/aap.2025-10972.eng
TL;DR: 2010–2023年251名兒童 solid tumors 患者中，PJP 累積發生率2.4%（95% CI 0.9–5.1），incidence rate 8.4/1000 person-years，感染距癌症診斷中位2.7個月。
不嘻嘻：solid tumors 小孩的 PJP，低調但不能忘。
The black aspergilli (Aspergillus niger complex) and their role in human, animal, and plant diseases¶
Authors: Bongomin F et al. | Journal: Clin Microbiol Rev | Date: 2026 Jun 02
DOI: 10.1128/cmr.00158-25
TL;DR: A. niger complex 可致 otomycosis、keratitis、chronic pulmonary aspergillosis 與少數 invasive aspergillosis；常見 triazoles MIC 偏高，itraconazole、isavuconazole 療效可能受限。
不嘻嘻：黑色 Aspergillus 看起來也不太好惹。
Predictors of viral non-suppression among key populations in Lagos, Nigeria: a retrospective matched case-control study¶
Authors: Madubueze RE et al. | Journal: AIDS Care | Date: 2026 Jun 02
DOI: 10.1080/09540121.2026.2679506
TL;DR: 拉哥斯520名 ART-experienced key populations 的 matched case-control 顯示，baseline VL >1000 copies/mL 強烈預測 viral non-suppression（aOR 6.85），TB coinfection 亦增加風險（aOR 2.34）。
不嘻嘻：viral load 一高，ART 劇本就開始歪。
Real-World Efficacy and Safety of Liposomal Amphotericin B for Invasive Fungal Disease in Patients with Hematologic Malignancies: A Multicenter Retrospective Study¶
Authors: Lu T et al. | Journal: Drug Des Devel Ther | Date: 2026
DOI: 10.2147/DDDT.S605938
TL;DR: 中國100名 hematologic malignancies 合併 IFD 患者接受 L-AmB，中位療程12天，treatment success 71.0%；hypokalemia 52.0%最常見，51%達成療效且無 severe AEs。
嘻嘻：L-AmB 還能打，只是鉀離子要顧好。
Multimorbidity and the risk of post-tuberculosis lung disease: a systematic review and meta-analysis¶
Authors: Hill KJ et al. | Journal: BMJ Glob Health | Date: 2026 Jun 01
DOI: 10.1136/bmjgh-2025-020365
TL;DR: 41篇 LMICs 研究的 meta-analysis 顯示，PTLD 定義差異大且58.5%高 bias；HIV 與較低 PTLD odds 相關（OR 0.68），undernutrition 則增加 abnormal spirometry（OR 1.99）。
不嘻嘻：PTLD 證據很亂，肺也很難收尾。
Adaptation of a Smartphone-Based Mobile Health Program to Support Person-Centered Treatment of Tuberculosis in Kilimanjaro, Tanzania: Preimplementation Qualitative Needs Assessment¶
Authors: Ngowi K et al. | Journal: JMIR Form Res | Date: 2026 Jun 01
DOI: 10.2196/92051
TL;DR: 坦尚尼亞吉力馬札羅25人質性訪談顯示，provider 端 smartphone access 達100%，TB 患者僅36%；網路穩定性與 data bundle 成本是 mHealth 導入主要障礙。
不嘻嘻：mHealth 很潮，但 data bundle 不買單。
🟢 One Health / Zoonoses¶
Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline¶
Authors: Stuart WS et al. | Journal: Nat Commun | Date: 2026 Jun 01
DOI: 10.1038/s41467-026-73421-5
TL;DR: cryo-EM 顯示 doxycycline 除 A site 外也結合 ribosome exit tunnel；在 C. burnetii 有3個分子堆疊阻塞，在 E. coli 則誘發 PTC 構形改變並阻斷 tRNA binding。
嘻嘻：doxycycline 竟有多重卡位，ribosome 很忙。
Rab11B is required for binding and entry of recent H3N2, but not H1N1, influenza A isolates¶
Authors: Turner AH et al. | Journal: J Virol | Date: 2026 Jun 02
DOI: 10.1128/jvi.02111-25
TL;DR: Rab11B depletion 使2022年 H3N2 binding 約降50%，並減少 infected cells，但不影響 H1N1；缺陷定位至 HA gene，提示近期 H3N2 entry 依賴特定 sialylated surface proteins。
嘻嘻：H3N2 entry 又多一個可盯的門把。
Molecular detection of relapsing fever Borrelia puertoricensis in migratory Mexican free-tailed bats¶
Authors: Becker DJ et al. | Journal: mSphere | Date: 2026 Jun 02
DOI: 10.1128/msphere.00085-26
TL;DR: 奧克拉荷馬近400隻 Mexican free-tailed bats 的2022–2023年調查首次在蝙蝠偵測 Borrelia puertoricensis，prevalence 低但支持其可能參與北美 tick-borne pathogen dispersal。
不嘻嘻：bats 帶線索飛過來，ticks 又加戲。
OmpU elicits cross-protective bactericidal activity against Vibrio species: a surface-exposed antigen with vaccine potential¶
Authors: Yuan S et al. | Journal: J Appl Microbiol | Date: 2026 Jun 02
DOI: 10.1093/jambio/lxag129
TL;DR: OmpU 免疫可誘發高 titer antisera（最高1:243,000），對多種 Vibrio species 具 cross-reactivity 與 bactericidal activity（titer 1:512），優於 VP0802 的1:32。
嘻嘻：OmpU 這張 vaccine 牌，看起來有點香。
Silent carriage of mcr-9 on IncHI2 plasmid in an Enterobacter hormaechei strain causing a urinary tract infection in a dog from Portugal¶
Authors: Menezes J et al. | Journal: Vet Microbiol | Date: 2026 Jun 01
DOI: 10.1016/j.vetmic.2026.111104
TL;DR: 葡萄牙犬 UTI 分離的 Enterobacter hormaechei 帶 mcr-9 IncHI2 plasmid 但仍 colistin susceptible；缺 qseC/qseB 可能解釋 silent carriage，凸顯 companion animals 的 One Health surveillance 需求。
不嘻嘻：mcr-9 安靜搭便車，狗狗也進 One Health。
High Burden of Intestinal Protozoan Infections Revealed by Molecular Diagnostics among Schoolchildren in the Marshall Islands: Species Diversity, Genotyping, and Risk Factors¶
Authors: Too YX et al. | Journal: Int J Infect Dis | Date: 2026 May 31
DOI: 10.1016/j.ijid.2026.108846
TL;DR: 馬紹爾群島215名學童 PCR 顯示 E. histolytica 97.2%、G. lamblia 87.0%、Cryptosporidium spp. 2.8%；PCR 分別比 microscopy 多偵測13倍與35倍感染。
不嘻嘻：PCR 一開，腸道 protozoa 直接開派對。
Expanding diversity of tick-borne phleboviruses (Phlebovirus mukawaense, Mudanjiang phlebovirus, Gomselga Virus, and Onega tick phlebovirus) in Russia¶
Authors: Kartashov MY et al. | Journal: PLoS One | Date: 2026
DOI: 10.1371/journal.pone.0349564
TL;DR: 亞洲俄羅斯143地點1078隻 Ixodes persulcatus ticks 中偵測27株 tick-borne phleboviruses，Gomselga virus prevalence 1.5%最高，並見 MKWV 與 Borrelia miyamotoi 等 coinfections。
不嘻嘻：ticks 的病毒名單，又默默加長一頁。
Dynamics of zoonotic soil-transmitted helminth infections in wild African green monkey (Chlorocebus aethiops sabaeus)¶
Authors: Teng Y et al. | Journal: Parasitology | Date: 2026 Jun 02
DOI: 10.1017/S0031182026102212
Hydroxamate Siderophores Drive Persistent Free Radical Generation to Suppress Antibiotic Resistance Gene Dissemination and Enhance Humification during Composting¶
Authors: Yi S et al. | Journal: Environ Sci Technol | Date: 2026 Jun 02
DOI: 10.1021/acs.est.6c00828
TL;DR: 40天 rice straw/pig manure composting 中，HDS 使 humification 加速24.7%、SQ•- 增加2.1–7.4倍，plasmid-mediated conjugative transfer 降65.3–84.4%，mid/high-risk ARGs 降11.6–26.6%。
嘻嘻：composting 也能壓 ARGs，環保突然很硬派。
Brucellosis Surveillance - United States, 2010-2024¶
Authors: Locke NS et al. | Journal: MMWR Surveill Summ | Date: 2026 Jun 04
DOI: 10.15585/mmwr.ss7502a1
TL;DR: 美國2010–2024年通報1796例 brucellosis，878例有補充 CRF，其中503例符合 CSTE 定義；61%有旅遊史，國際旅遊者73%暴露於未殺菌乳品或未熟肉品。
不嘻嘻：brucellosis 老派但穩，未殺菌乳品再補刀。
🟡 Food Security / Food Safety¶
A lack of clean drinking water is associated with lacking food and experiencing food safety threats in 121 countries across the globe¶
Authors: Bruine de Bruin W et al. | Journal: Nat Food | Date: 2026 Jun 01
DOI: 10.1038/s43016-026-01363-8
TL;DR: 121國124,003人 World Risk Poll 顯示，過去一年缺食逾1天與缺 clean drinking water 逾1天相關；兩者共存或任一存在皆增加 food safety threats 與擔憂。
不嘻嘻：沒水又缺食，感染風險地基先塌一半。
Bimetallic Ce/Zr-MOF nanozyme for integrated colorimetric detection and degradation of tetracycline in foods¶
Authors: Du L et al. | Journal: Food Chem | Date: 2026 May 27
DOI: 10.1016/j.foodchem.2026.149834
TL;DR: Ce/Zr-MOF nanozyme 可用 colorimetric assay 偵測食品 tetracycline，0–40 μM 線性、detection limit 0.368 μM；同時產生 •OH radicals 促進 TC degradation。
嘻嘻：食品 tetracycline 可偵測又可降解，很划算。
Molecular typing and genomic characterization of persistent Listeria monocytogenes clones in a bakery production facility¶
Authors: Almeida G et al. | Journal: Int J Food Microbiol | Date: 2026 May 25
DOI: 10.1016/j.ijfoodmicro.2026.111874
TL;DR: 烘焙廠68株 L. monocytogenes 分為3個 molecular serotypes、17種 PFGE types、10種 cgMLST types；CC2與CC9兩個 persistent clones 占86%，但未能連結特定 genomic determinants。
不嘻嘻：Listeria 在烘焙廠住太久，像有門牌。
Novel N'-Phenyl Benzyl Carbazate Derivatives with Potent Multiple Antifungal Activity: Design, Structure-Activity Relationship, and Action Mode¶
Authors: Wang Y et al. | Journal: J Agric Food Chem | Date: 2026 Jun 01
DOI: 10.1021/acs.jafc.6c02545
TL;DR: 30個 N'-phenyl benzyl carbazates 中26個對6種 phytopathogenic fungi 的平均 EC50 為0.316–4.617 μg/mL；2f 在番茄 A. solani 第7天 control efficacy 96.3%。
嘻嘻：新 antifungal 骨架冒頭，植物病害先期待。
Food purchase patterns in Nairobi before, during, and after the COVID-19 pandemic lockdown measures¶
Authors: Momanyi R et al. | Journal: PLOS Glob Public Health | Date: 2026
DOI: 10.1371/journal.pgph.0006544
TL;DR: 奈洛比2家超市2018–2023年11,105,974筆交易的 interrupted time series 顯示，COVID lockdown 短期降低 UPF、增加 minimally processed foods，但 post-COVID 多數改變反轉。
不嘻嘻：lockdown 飲食短暫變好，之後又被打回原形。
Isolation and characterization of a novel lytic phage Artin targeting typhoidal and nontyphoidal Salmonella and evaluation of its antibacterial efficacy in food¶
Authors: Ramezannia Z et al. | Journal: Virol J | Date: 2026 Jun 01
DOI: 10.1186/s12985-026-03204-3
TL;DR: phage Artin 具 strictly lytic、耐4–70°C與pH 2–12，宿主含 S. Enteritidis、S. Typhimurium、S. Typhi 與 E. coli；4°C下在雞胸與牛奶可降 Salmonella 1.3–3.1 log10 CFU/mL。
嘻嘻：phage Artin 低溫也能清 Salmonella，很務實。
Seasonal impacts on Salmonella prevalence and antimicrobial resistance in the pork food chain of northeastern Thailand¶
Authors: Liu H et al. | Journal: Appl Environ Microbiol | Date: 2026 Jun 02
DOI: 10.1128/aem.00057-26
TL;DR: 泰國東北897件豬肉鏈樣本中，retail pork Salmonella prevalence 最高（夏75.4%、雨季75.3%、冬54.7%）；雨季與 AMR 強相關（OR 11.9），冬季由 S. Rissen 主導。
不嘻嘻：豬肉鏈 Salmonella 太熱鬧，雨季還加抗藥性。
Microbiological quality assessment of potential pathogenic bacteria and multidrug resistance patterns in commercial electrolyte drinks in Dhaka, Bangladesh¶
Authors: Saha S et al. | Journal: PLoS One | Date: 2026
DOI: 10.1371/journal.pone.0336888
TL;DR: 達卡40件 electrolyte drinks 全數有 bacteria，40% aerobic plate count 超 FDA 限值、55%有 fecal contamination；分離 K. pneumoniae、E. coli、A. baumannii、Vibrio spp. 等且多為 MDR。
不嘻嘻：electrolyte drinks 變菌湯，喝前先深呼吸。
miR408-5p and miR408-3p cooperatively reduce cadmium uptake and accumulation in rice¶
Authors: Rong F et al. | Journal: PLoS Biol | Date: 2026 Jun
DOI: 10.1371/journal.pbio.3003811
TL;DR: MIR408 產生的 miR408-5p 與 miR408-3p 分別抑制 HIPP19 與 UCL7，降低水稻根部 Cd uptake；HIPP19/UCL7 knockout 與 MIR408 overexpression 均可降 rice grains Cd 而不影響 essential metals。
嘻嘻：rice Cd 能降，還不太傷 essential metals。
Associations Between Social Determinants of Health and Epilepsy Prevalence in U.S. Adults: NHANES1999-2018¶
Authors: Li B et al. | Journal: Neuroepidemiology | Date: 2026 Jun 02
DOI: 10.1159/000552729
TL;DR: NHANES 1999–2018年36,458名成人中，epilepsy 加權盛行率1.1%；整體 SDoH index 與 epilepsy odds 增3倍相關（OR 3.03），food security 貢獻最大（weight 0.39）。
不嘻嘻：epilepsy 也照見 SDoH，食物安全最扎心。
資料來源：PubMed (articles retrieved 2026-06-03)