Daily Journal Digest — 2026-06-02¶

過去 24 小時新增：Transplant ID × 12、One Health × 12、Food Security × 12，共 36 篇。

🔴 Transplant & Opportunistic Infections¶

Glucocorticoid use and candidemia: results from a nationwide case-control study¶

Authors: Leding C et al. | Journal: Clin Microbiol Infect | Date: 2026 May 30
DOI: 10.1016/j.cmi.2026.05.033
TL;DR: 丹麥2010–2024年case-control納入6,179例candidemia；oral glucocorticoid暴露aOR 2.17，高劑量達5.23，IBD最高4.62。

不嘻嘻：steroid救火，也順手幫Candidia開派對。

Post-Viral Aspergillosis: A Systematic Review of Incidence, Clinical Manifestations, and Outcomes¶

Authors: Akhavan M et al. | Journal: Rev Med Virol | Date: 2026 May
DOI: 10.1002/rmv.70163
TL;DR: systematic review顯示PVA主要見於SARS-CoV-2、influenza與CMV後，重症、immunocompromised或corticosteroids使用者死亡風險高，需早期診斷與antifungal therapy。

不嘻嘻：viral後場還有Aspergillus補刀，ICU真的很忙。

Metformin exerts a dual effect on Mucorales virulence by altering oxidative metabolism through the regulation of rhizoferrin levels¶

Authors: Patiño-Medina JA et al. | Journal: Med Mycol | Date: 2026 Jun 01
DOI: 10.1093/mmy/myag053
TL;DR: metformin對Mucorales virulence呈濃度雙相效應：低濃度增強mitochondrial activity與•OH，高濃度則經AMPK/mitophagy降低virulence。

嘻嘻：metformin連Mucorales都能被玩出雙面劇本。

Drug-Resistant Tuberculosis Outcomes in South Kivu Province, Democratic Republic of Congo, During a Humanitarian Crisis (2018-2024)¶

Authors: Musafiri EM et al. | Journal: Open Forum Infect Dis | Date: 2026 May
DOI: 10.1093/ofid/ofag303
TL;DR: 南基伍2018–2024年277名DR-TB患者全用bedaquiline regimen，成功率77.6%、死亡13.4%；rural residence保護，非relapse retreatment預後較差。

嘻嘻：humanitarian crisis裡DR-TB還能有這成績，值得多看一眼。

Development and Internal Validation of a Nomogram Model to Predict Invasive Pulmonary Aspergillosis Occurrence Risk in ICU Patients with Sepsis¶

Authors: Li H et al. | Journal: Infect Drug Resist | Date: 2026
DOI: 10.2147/IDR.S603823
TL;DR: 單中心574名sepsis ICU患者中86例(15.0%)發生IPA；nomogram含corticosteroid、viral coinfection、MV時間、NRS 2002與SOFA，validation AUC 0.844。

嘻嘻：sepsis ICU若能早抓IPA，值班少一點玄學。

Atomically Precise Polyanionic Boron Cluster Agents with Broad-Spectrum Antiviral Activity¶

Authors: Wang Y et al. | Journal: Precis Chem | Date: 2026 May 25
DOI: 10.1021/prechem.6c00019
TL;DR: dodecaborate-based polyanionic clusters在mammalian cells細胞毒性低，部分結構對HIV-1與CMV具antiviral activity，可作結構活性研究scaffold。

嘻嘻：boron cluster看起來像抗病毒工具箱新零件。

Advances in cryptococcal infections-associated immunopathology and potential therapeutic strategies¶

Authors: Sachivkina N et al. | Journal: Front Pharmacol | Date: 2026
DOI: 10.3389/fphar.2026.1776489
TL;DR: cryptococcal infections治療仍受5-flucytosine、fluconazole、amphotericin B選項有限、毒性、resistance與blood-brain barrier限制，需新策略。

不嘻嘻：cryptococcosis治療選項少到像在翻舊抽屜。

Acetylation and accessibility of Cryptococcus neoformans cell wall chitosans influence the strength of host immune responses¶

Authors: Hellmann MJ et al. | Journal: Cell Surf | Date: 2026 Jun
DOI: 10.1016/j.tcsw.2026.100175
TL;DR: Cryptococcus neoformans cell wall chitosan的acetylation與accessibility受chitin deacetylase與生長條件影響，決定host immune response強弱。

嘻嘻：C. neoformans cell wall也有免疫音量旋鈕。

CMV-specific T-cell receptor-engineered T-cell therapy as first-line treatment for CMV reactivation after haploidentical hematopoietic stem cell transplantation: a phase 2 trial¶

Authors: Tang J et al. | Journal: Front Immunol | Date: 2026
DOI: 10.3389/fimmu.2026.1820399
TL;DR: phase 2試驗25例haplo-HSCT中13例CMV reactivation接受TCR-T；4週CR 92.3%，中位追蹤1011天，僅2例grade 1 CRS。

嘻嘻：CMV TCR-T一出手，transplant ward眼睛亮了。

Cost Impact of a Novel Pre-transplant Risk Assessment Tool for Early Acute Rejection in Kidney Transplant Patients¶

Authors: Cooper JT et al. | Journal: J Health Econ Outcomes Res | Date: 2026
DOI: 10.36469/001c.146282
TL;DR: PTRA用於standard-risk kidney transplant模型可省每人90天358美元、2年13,234美元；若納入14,468人，2年可省1.91億美元。

嘻嘻：transplant前先算風險，錢包和graft都開心。

Managing Azole Resistance in Aspergillus¶

Authors: Kushima H et al. | Journal: Med Mycol J | Date: 2026
DOI: 10.3314/mmj.26.008
TL;DR: azole-resistant Aspergillus fumigatus上升威脅aspergillosis治療，常見cyp51A mutation與azole cross-resistance；susceptibility testing不足使管理更困難。

不嘻嘻：azoles越用越心虛，susceptibility又常缺席。

Plasmablastic lymphoma through clonal expansion 17 years after EBV-positive DLBCL: case report and review¶

Authors: Ishii K et al. | Journal: J Clin Exp Hematop | Date: 2026 May 30
DOI: 10.3960/jslrt.26012
TL;DR: 67歲男EBV-positive DLBCL緩解17年後發生PBL；NGS immunoglobulin repertoire顯示PBL可能源自原先minor subclone的長期clonal expansion。

不嘻嘻：17年後subclone回來打招呼，真的很會等。

🟢 One Health / Zoonoses¶

Community zoonoses prioritization (CZP): A One Health tool integrating participatory epidemiology and multicriteria decision analysis¶

Authors: Mumin FI et al. | Journal: One Health | Date: 2026 Jun
DOI: 10.1016/j.onehlt.2026.101450
TL;DR: CZP結合Participatory Epidemiology與MCDA，以六步驟在單次session完成zoonoses prioritization，低識字社群也能產生可分析排序與行動規劃。

嘻嘻：One Health工具若能進社區，排序就不只在會議室。

Antimicrobial resistant E. coli in animals, humans and the environment within household and compound settings: A scoping review¶

Authors: Gutema FD et al. | Journal: One Health | Date: 2026 Jun
DOI: 10.1016/j.onehlt.2026.101452
TL;DR: scoping review納入40篇，household/compound中AMR E. coli盛行率AH 63%、AHE 36.5%、AE 46%，13篇AH研究見動物與人類genetic relatedness。

不嘻嘻：AMR E. coli在家戶流動，門檻比想像低。

Investigating a Skin Disease in Guinea Baboons (Papio papio) Using Non-invasive Methods¶

Authors: Ramon M et al. | Journal: Ecohealth | Date: 2026 Jun 01
DOI: 10.1007/s10393-026-01799-1
TL;DR: 幾內亞比索野生Guinea baboons以107點位、2224 camera trap days與272樣本偵測皮膚病；至少7隻有病灶，PCR未確認M. leprae或T. pallidum。

不嘻嘻：非侵入式查皮膚病，答案仍很害羞。

Governance of antimicrobial resistance in Central Africa (2015-2025): a systematic review of policies, One Health coordination and funding¶

Authors: Kamsu GT et al. | Journal: JAC Antimicrob Resist | Date: 2026 Jun
DOI: 10.1093/jacamr/dlag093
TL;DR: 中非AMR governance systematic review納入27份文件；6國有NAPs，但One Health落實、surveillance、laboratory capacity與國內financing仍薄弱。

不嘻嘻：AMR policy有了，落地還是一路卡關。

The WHO costing and budgeting tool for national action plans on antimicrobial resistance-a review and assessment of impact in Africa¶

Authors: Mazengiya YD et al. | Journal: JAC Antimicrob Resist | Date: 2026 Jun
DOI: 10.1093/jacamr/dlag094
TL;DR: WHO AFRO 15國使用AMR NAP costing tool後，11國以costed data募資，7國影響政策；主要瓶頸仍是國內financing不足與donor priority不合。

不嘻嘻：costed NAP會算錢，但錢不一定會來。

Commercial determinants of health: an approach for strengthening One Health interventions¶

Authors: Ebata A et al. | Journal: Front Public Health | Date: 2026
DOI: 10.3389/fpubh.2026.1787079
TL;DR: CDoH lens可補強One Health，分析intensified animal production中非公部門誘因、市場動態與zoonotic risk、AMR、環境衝擊間的取捨。

嘻嘻：把市場誘因算進One Health，終於比較像現實。

A comparison of antibiotic resistance reports in pharmacovigilance databases and conventional surveillance across "One Health"¶

Authors: Mitchell J et al. | Journal: Front Public Health | Date: 2026
DOI: 10.3389/fpubh.2026.1758180
TL;DR: pharmacovigilance資料庫抓到VigiBase 26,086件、EudraVigilance Veterinary 1,010件抗生素抗藥性報告，與傳統surveillance的ATC分布顯著不同。

嘻嘻：pharmacovigilance也能挖AMR訊號，雷達多一支。

Trichinella spiralis HSP70 Mediates Mice Immune Responses via TLR2/MyD88/ERK Signaling Pathway¶

Authors: Feng J et al. | Journal: Transbound Emerg Dis | Date: 2026
DOI: 10.1155/tbed/5533482
TL;DR: Trichinella spiralis Ts-HSP70可經TLR2/MyD88/ERK活化macrophage，增加NO、ROS與cytokine mRNA；PLGA nanoparticle疫苗使小鼠muscle larvae降28%。

嘻嘻：parasite HSP70拿來當疫苗線索，頗有戲。

First report of traumatic myiasis in the wild Komodo dragon (Varanus komodoensis Ouwens, 1912) from Indonesia¶

Authors: Winarso A et al. | Journal: Vet Res Commun | Date: 2026 Jun 01
DOI: 10.1007/s11259-026-11310-4
TL;DR: 2025年印尼Komodo National Park首次記錄野生Komodo dragon traumatic myiasis；幼蟲皆為Chrysomya rufifacies，推估infestation後2–3天。

不嘻嘻：wound myiasis連野外大個體也不放過。

The Role of ES&T in Advancing Environmental Toxicology and Chemical Risk Assessment: Past, Present, and Future¶

Authors: Escher BI et al. | Journal: Environ Sci Technol | Date: 2026 Jun 01
DOI: 10.1021/acs.est.6c03315
TL;DR: 回顧ES&T 60年environmental toxicology指出，整合ecotoxicology、human toxicology、exposomics與NAMs，可將risk assessment推向mechanism-based One Health模式。

嘻嘻：toxicology走向mechanism-based，One Health更有骨架。

New strains, new threats: the rise of atypical non-typhoidal Salmonella serovars and what it means for global health¶

Authors: Campbell A et al. | Journal: Crit Rev Microbiol | Date: 2026 Jun 01
DOI: 10.1080/1040841X.2026.2668055
TL;DR: atypical non-typhoidal Salmonella serovars因全球貿易、政策與globalization增加，具新host adaptation、AMR profile與infection sources，需One Health監測。

不嘻嘻：Salmonella serovars換新招，食安又加班。

Establishment of an indirect ELISA method for detecting Salmonella infection based on Sptp protein in poultry¶

Authors: Xie L et al. | Journal: J Microbiol Methods | Date: 2026 May 30
DOI: 10.1016/j.mimet.2026.107560
TL;DR: 以SptP protein建立poultry Salmonella indirect ELISA，可偵測1:1600稀釋serum，intra/inter-assay CV均<10%，與commercial ELISA結果完全一致。

嘻嘻：poultry Salmonella篩檢若更順，防線就早一點。

🟡 Food Security / Food Safety¶

Emergence and genomic characterization of Listeria monocytogenes causing human listeriosis in Pakistan, 2017-2023¶

Authors: Ahmed I et al. | Journal: BMC Microbiol | Date: 2026 May 30
DOI: 10.1186/s12866-026-05236-9
TL;DR: 巴基斯坦2017–2023年Listeria monocytogenes臨床分離增至142例，90例bloodstream、47例CNS；24株WGS多屬CC1、serogroup 4b、lineage I。

不嘻嘻：L. monocytogenes在臨床冒頭，食安警鈴很響。

Native rhizobia nodulating soybean (Glycine max (L.) Merr.) performs better than commercial strain across locations in South Ethiopia Region¶

Authors: Dalo DD et al. | Journal: Sci Rep | Date: 2026 May 30
DOI: 10.1038/s41598-026-55131-6
TL;DR: 南衣索比亞44株native rhizobia中SB19表現最佳，田間soybean產量2.39–3.10 tons/ha，顯著高於commercial strain 2.25–2.40 tons/ha。

嘻嘻：native rhizobia贏commercial strain，土壤也有地主優勢。

Prevalence and Genetic Diversity of Toxoplasma gondii in Foods: A Global Systematic Review and Meta-Analysis¶

Authors: Shamsi L et al. | Journal: Foodborne Pathog Dis | Date: 2026 Jun 01
DOI: 10.1177/15353141261451633
TL;DR: global meta-analysis納入34研究、142 datasets，食品中Toxoplasma gondii pooled prevalence 8.2%；raw meats最高11.9%、non-leafy vegetables 11.4%。

不嘻嘻：T. gondii藏進食物鏈，沙拉和肉都要小心。

A Review of Reclaimed Water Use for Irrigation of Produce Crops and Food Safety Aspects in the United States¶

Authors: Reyes GA et al. | Journal: J Food Prot | Date: 2026 May 29
DOI: 10.1016/j.jfp.2026.100824
TL;DR: 美國reclaimed water灌溉produce缺乏一致聯邦規範；病原如Cyclospora cayetanensis與emerging chemical hazards處理效能仍不確定，影響採用與食安評估。

不嘻嘻：reclaimed water想上桌，規範和風險還在拉扯。

High thermal resistance and inactivation behaviour of Clostridioides difficile spores in milk¶

Authors: Taylan Yalçın G et al. | Journal: Braz J Microbiol | Date: 2026 Jun 01
DOI: 10.1007/s42770-026-01975-z
TL;DR: 牛奶中Clostridioides difficile spores熱抗性高，85°C約7-log reduction，但≤77.5°C 60分鐘仍<2.2-log；常規pasteurization不足以完全清除。

不嘻嘻：C. difficile spores泡牛奶，熱處理也不太怕。

Characterization of Lactiplantibacillus plantarum IM3, a Salmonella-antagonistic strain isolated from garbage enzyme: genome analysis, mechanism of action, and mRNA transcription kinetics¶

Authors: Ngo TPN et al. | Journal: World J Microbiol Biotechnol | Date: 2026 Jun 01
DOI: 10.1007/s11274-026-05040-7
TL;DR: Lactiplantibacillus plantarum IM3對S. enterica Typhimurium抑制圈8.10 mm，co-culture抑制率99.44%，CFS 24小時可降低lettuce上可回收菌量。

嘻嘻：friendly bacteria幫忙壓S. enterica，生菜有救援感。

Evaluating Toxoplasmosis Molecular Prevalence in Slaughtered Sheep using PCR Assay in Northern Palestine¶

Authors: Qash H et al. | Journal: Acta Parasitol | Date: 2026 Jun 01
DOI: 10.1007/s11686-026-01316-y
TL;DR: 北巴勒斯坦346隻屠宰羊PCR顯示Toxoplasma gondii DNA盛行率25.7%；ewe 52%高於ram 21.3%，tongue tissue最高21.8%。

不嘻嘻：slaughterhouse一篩就不少T. gondii，烹調別偷懶。

A MXene@GQDs hybrid fluorescent array for rapid identification and quantification of foodborne pathogens¶

Authors: Zhang X et al. | Journal: Mikrochim Acta | Date: 2026 Jun 01
DOI: 10.1007/s00604-026-08142-z
TL;DR: MXene@GQDs fluorescence array可於3分鐘辨識6種foodborne pathogens，最低驗證濃度1.0×10^3 CFU/mL，在自來水、牛奶與mixed-bacteria樣本維持100% accuracy。

嘻嘻：3分鐘抓foodborne pathogens，檢驗室會想加購。

Aflatoxin B1 and food safety: Mechanisms of action associated to Hepatocellular Carcinoma¶

Authors: Zamudio MC et al. | Journal: Arch Microbiol | Date: 2026 Jun 01
DOI: 10.1007/s00203-026-04978-4
TL;DR: AFB1經CYP3A4/CYP1A2 bioactivation產生AFBO，形成DNA adducts並促進p53、ras G-to-T transversions；需整合HBV vaccination與biocontrol降低暴露。

不嘻嘻：AFB1到HCC這條路，食品安全不能裝沒事。

Functional characterization of iucC and iucD in iron acquisition and virulence of Cronobacter sakazakii¶

Authors: Meng X et al. | Journal: Braz J Microbiol | Date: 2026 Jun 01
DOI: 10.1007/s42770-026-01978-w
TL;DR: Cronobacter sakazakii iucC/iucD在iron-limited條件顯著上調；knockout降低siderophore、intracellular iron，並削弱Caco-2 adhesion與invasion。

嘻嘻：抓到C. sakazakii iron路徑，virulence有新把柄。

Diversity and selected functional traits of microbiota associated with traditional dried plant foods from South African informal markets¶

Authors: Wassermann B et al. | Journal: FEMS Microbes | Date: 2026
DOI: 10.1093/femsmc/xtag026
TL;DR: 南非51件傳統乾燥植物食品16S分析顯示microbiota差異大；baobab richness最高1460 ASVs，leafy greens bacterial load最高達10^9 copies/g。

不嘻嘻：傳統乾燥食品microbiota豐富到有點緊張。

Production optimization and in vitro evaluation of the biofunctional potential of folate from Lactiplantibacillus plantarum-MGKMVIT11¶

Authors: Megala G et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1811272
TL;DR: Lactiplantibacillus plantarum MGKMVIT11最佳化後folate產量364.35 μg/mL、較未最佳化增1.64倍，並具antioxidant與anti-inflammatory activity。

嘻嘻：L. plantarum順手產folate，functional food很會包裝。

資料來源：PubMed (articles retrieved 2026-06-02)