Daily Journal Digest — 2026-05-31¶
過去 24 小時新增：Transplant ID × 5、One Health × 10、Food Security × 12，共 27 篇。
⭐ 今日亮點¶
- Non-HIV Pneumocystis jirovecii pneumonia-associated immune reconstitution inflammatory syndrome: a case report and systematic review
Non-HIV PJP-IRIS臨床上嚴重低估；IL-6動態監測與glucocorticoid重啟策略具直接處置指引價值。 - Addressing the dual-use of antifungals and fungal antimicrobial resistance (fAMR) through a One Health approach
農業與醫療共用azoles驅動fAMR加速，提出One Health整合政策，具即時公衛影響力。 - High prevalence of carbapenem-resistant Pseudomonas spp. in the pork production chain: a potential reservoir for zoonotic transmission
豬肉生產鏈中carbapenem-resistant Pseudomonas盛行率高，首次確認食品鏈為人畜共通傳播儲菌庫。 - Evolution of Salmonella Typhimurium under antibiotics from distinct classes reveals variant-dependent cross-protection against food preservation treatments
抗生素暴露使Salmonella對食品保存熱/酸處理產生交叉耐受，顛覆傳統食品加工安全假設。 - Glycoprotein B genotypes and clinical features in patients with recurrent cytomegalovirus anterior segment infection
台灣本土CMV眼部感染gB基因型追蹤，支持長期抗病毒維持治療的必要性，亞太臨床直接適用。
🔴 Transplant & Opportunistic Infections¶
Recreational drug inhalation and socioenvironmental determinants of pulmonary infection in patients with HIV: a hospital-based case control study¶
Authors: Blount RJ et al. | Journal: BMC Public Health | Date: 2026-05-30
DOI: 10.1186/s12889-026-27957-2
TL;DR: HIV患者中，吸菸（aOR 6.43）與無家可歸（aOR 3.22）顯著升高肺部感染風險，近期吸大麻者反而風險較低（aOR 0.21）。
不嘻嘻：—貧困、吸菸、無家可歸構成HIV患者的肺部感染三重奏，老問題年年唱，社會決定因子依舊難解。
Non-HIV Pneumocystis jirovecii pneumonia-associated immune reconstitution inflammatory syndrome: a case report and systematic review¶
Authors: Turhon G et al. | Journal: BMC Infect Dis | Date: 2026-05-29
DOI: 10.1186/s12879-026-13710-y
TL;DR: Non-HIV患者PJP治療中快速停用glucocorticoid可誘發IRIS；動態監測IL-6並重啟glucocorticoid後預後改善。
嘻嘻：—終於有系統回顧提醒我們non-HIV PJP停glucocorticoid要小心，IL-6飆升就是IRIS的線索！
Determination of the yearly distribution of the incidence of Allergic Bronchopulmonary Aspergillosis (ABPA) in patients registered in the cystic fibrosis patient registry system of Turkey and identification of risk factors for its development¶
Authors: Demir HI et al. | Journal: Chronic Illn | Date: 2026-05-30
DOI: 10.1177/17423953261452631
TL;DR: 土耳其CF登錄系統分析顯示，低肺功能值、頻繁急性惡化及慢性細菌定殖為ABPA發生的主要危險因子。
不嘻嘻：—CF患者本已千瘡百孔，偏偏低肺功能又是ABPA高危，雙重打擊真的好難過。
Convergence of neuroinflammation across major neurotropic viral exposomes in AD and ADRD¶
Authors: Harmouch J et al. | Journal: J Neuroinflammation | Date: 2026-05-29
DOI: 10.1186/s12974-026-03876-2
TL;DR: CMV、HIV、SARS-CoV-2等多種嗜神經病毒透過NF-κB等匯聚神經炎症路徑加速阿茲海默症進展，APOE4攜帶者風險尤高。
不嘻嘻：—病毒感染和失智症愈來愈難分難解，感染科醫師的工作又多了一條神經科的尾巴。
Glycoprotein B genotypes and clinical features in patients with recurrent cytomegalovirus anterior segment infection¶
Authors: Hsu HT et al. | Journal: Br J Ophthalmol | Date: 2026-05-29
DOI: 10.1136/bjo-2025-327910
TL;DR: CMV前房感染復發主要為gB1/gB3株再活化；老年患者可同時出現新株感染，強調長期抗病毒維持治療的必要性。
嘻嘻：—台灣長庚的CMV眼部資料，老年患者gB型別追蹤有助於判斷是再活化還是再感染，臨床實用！
🟢 One Health / Zoonoses¶
Genomic characterization of multidrug-resistant monophasic Salmonella 4,[5],12:I:- ST34 circulating along the food chain of Central Italy¶
Authors: Riaz J et al. | Journal: Food Res Int | Date: 2026-05-13
DOI: 10.1016/j.foodres.2026.119445
TL;DR: WGS分析顯示義大利中部食品鏈中多重抗藥性單相型 Salmonella ST34廣泛流通，帶多種AMR基因且具跨環節傳播能力。
不嘻嘻：—Salmonella ST34橫行食品鏈，AMR基因全配備，歐洲食安形勢再拉警報。
From foodborne to environmental Yersinia enterocolitica: Comparative insights into antimicrobial resistance and virulence for food safety¶
Authors: Lou X et al. | Journal: Food Res Int | Date: 2026-05-14
DOI: 10.1016/j.foodres.2026.119442
TL;DR: WGS分析顯示環境株 Yersinia enterocolitica 帶更多AMR基因，食品株則毒力基因更豐富，兩類族群傳播風險迥異。
不嘻嘻：—Yersinia enterocolitica 一邊在食物裡練毒力、一邊在環境中練抗藥，兩面夾攻真讓人頭疼。
Young adults' perceptions and experiences in using mobile apps and wearables for health: a qualitative study with public involvement¶
Authors: Leuzzi G et al. | Journal: BMC Public Health | Date: 2026-05-29
DOI: 10.1186/s12889-026-27734-1
TL;DR: 質性研究顯示年輕成人使用健康APP與穿戴裝置的主要障礙為隱私疑慮及演算法透明度不足。
不嘻嘻：—數位健康工具理論上很美好，但年輕人的真實顧慮是「我的資料去哪了」，科技信任赤字難建立。
Current advances in antimicrobial feed additives for terrestrial livestock: A systematic review¶
Authors: Thng AHH et al. | Journal: Food Microbiol | Date: 2026-05-07
DOI: 10.1016/j.fm.2026.105146
TL;DR: 系統回顧顯示有機酸、植物化學物質等替代性抗菌飼料添加劑可降低牲畜人畜共通病原風險，但各研究間效果差異大。
嘻嘻：—禁用formaldehyde後還有有機酸和植物化合物可用，畜牧業微生物風險管理算是找到幾條出路。
Longitudinal surveillance and molecular characterization of methicillin-resistant Staphylococcus aureus (MRSA) from livestock carcasses in South Korea: A 12-year nationwide study (2013-2024)¶
Authors: Lee YH et al. | Journal: Food Microbiol | Date: 2026-05-02
DOI: 10.1016/j.fm.2026.105137
TL;DR: 南韓12年全國監測顯示畜牧場MRSA以CC398型為主，多重抗藥性呈持續上升趨勢，人畜共通傳播風險持續存在。
不嘻嘻：—CC398 MRSA 12年居高不下，韓國豬場和台灣豬場的問題其實是一家人。
High prevalence of carbapenem-resistant Pseudomonas spp. in the pork production chain: a potential reservoir for zoonotic transmission¶
Authors: Botelho A et al. | Journal: Food Microbiol | Date: 2026-04-05
DOI: 10.1016/j.fm.2026.105105
TL;DR: 豬肉生產鏈中carbapenem-resistant Pseudomonas spp.盛行率高，具人畜共通傳播潛力，可能成為臨床難治感染的環境儲菌庫。
不嘻嘻：—豬肉鏈裡的carbapenem-resistant Pseudomonas，從農場到餐桌一路帶著抗藥基因，吃肉多一層風險。
One health viral metagenomics for pathogen surveillance: robust mNGS workflows for viral detection and genome recovery from swab and tissue specimens¶
Authors: Russell T et al. | Journal: BMC Microbiol | Date: 2026-05-29
DOI: 10.1186/s12866-026-05105-5
TL;DR: 評估兩種宏基因組學（mNGS）工作流程，對多種宿主與樣本類型均有穩健病毒偵測效能，適用於One Health病毒監測。
嘻嘻：—mNGS工作流程通吃拭子和組織，跨宿主監測有了標準化方案，下次大流行提早發現的機會更大了！
Addressing the dual-use of antifungals and fungal antimicrobial resistance (fAMR) through a One Health approach¶
Authors: Weeks S et al. | Journal: NPJ Antimicrob Resist | Date: 2026-05-29
DOI: 10.1038/s44259-026-00220-9
TL;DR: 農業與醫療共用azoles等抗真菌藥驅動fAMR加速；英國政策案例指出分散治理為主因，呼籲建立One Health整合監控體系。
不嘻嘻：—農田噴的azoles跑進了病人的治療選項縫隙，fAMR問題政策分散、監管破洞，治理難度堪比堵九個洞的堤壩。
Ocular adnexal sporotrichosis: case series from a hyperendemic region in southern Brazil¶
Authors: Poester VR et al. | Journal: Med Mycol | Date: 2026-05-29
DOI: 10.1093/mmy/myag054
TL;DR: 巴西南部高地病區首批眼附屬器sporotrichosis系列病例，多由 Sporothrix brasiliensis 引起，眼部表現多樣，需早期積極治療。
嘻嘻：—sporotrichosis竟然爬上眼睛！巴西 Sporothrix brasiliensis 疫情持續擴張，臨床表現百變，診斷大考驗。
Integrating molecular tools into leishmaniosis surveillance: evaluation of a commercial qPCR kit in sand fly vectors¶
Authors: Dehesa-García B et al. | Journal: Parasit Vectors | Date: 2026-05-29
DOI: 10.1186/s13071-026-07440-y
TL;DR: 商業qPCR套組成功整合入沙蠅媒介監測流程，可提升地中海地區 Leishmania infantum 早期偵測效率。
嘻嘻：—商業qPCR套組直接上陣監測沙蠅，省去自建方法的麻煩，地方性leishmaniosis監測效率大躍進！
🟡 Food Security / Food Safety¶
Multiplexed electrochemical biosensors: system-level design frameworks, signal decoding strategies and translational perspectives for food safety¶
Authors: Zhou S et al. | Journal: Food Res Int | Date: 2026-05-21
DOI: 10.1016/j.foodres.2026.119499
TL;DR: 系統回顧多重電化學生物感測器在食品安全的設計框架與訊號解碼策略，同時偵測多種污染物具商業轉化潛力。
嘻嘻：—一次偵測多種污染物的電化學感測器正在成熟，食品安全快篩未來不再是夢，技術轉化只差臨門一腳。
Portulaca Oleracea polysaccharides attenuate zearalenone-induced macrophage activation and Leydig cell dysfunction in testis: A single-cell and multi-omics study¶
Authors: Huangfu B et al. | Journal: Food Res Int | Date: 2026-05-17
DOI: 10.1016/j.foodres.2026.119481
TL;DR: 馬齒莧多醣於小鼠模型中可透過多組學機制減緩zearalenone真菌毒素誘發的睪丸免疫失調與雄性生殖功能損害。
嘻嘻：—馬齒莧來護睪丸，對抗黴菌毒素的天然解方有了多組學支撐，食品農業交叉研究意外有點萌。
Translating Food Biosensing into Practice: Smart Packaging, On-Site Analytics, and AI Integration¶
Authors: Seyedhosseini-Ghaheh H et al. | Journal: Food Res Int | Date: 2026-05-16
DOI: 10.1016/j.foodres.2026.119473
TL;DR: 回顧生物感測器、智慧包裝與AI整合在食品安全即時監測的應用現況，臨床轉化仍面臨成本與監管挑戰。
嘻嘻：—智慧包裝內建感測器偵測病原，AI協助判讀，食品安全進入科幻時代，期待轉化成現實。
Simultaneous determination of N-nitrosamines in ready-to-cook dishes: optimized extraction-purification protocol and comparative quantification by GC-MS/MS versus GC-Q/TOF MS¶
Authors: Chen J et al. | Journal: Food Res Int | Date: 2026-05-14
DOI: 10.1016/j.foodres.2026.119454
TL;DR: 開發優化萃取方案搭配GC-MS/MS，可同時定量即食料理中多種N-亞硝胺類致癌物，填補加工食品安全分析空缺。
不嘻嘻：—即食料理裡暗藏亞硝胺致癌物，新分析法把它們一網打盡，但知道了又怎樣——還是得吃便利食品。
Enhancing microbial safety and enzymatic stability of green peas using sequential sodium hypochlorite washing and continuous in-package DBD plasma treatment¶
Authors: Muhammad AI et al. | Journal: Food Res Int | Date: 2026-05-12
DOI: 10.1016/j.foodres.2026.119452
TL;DR: 次氯酸鈉洗滌後in-package DBD電漿處理可有效滅活青豆上 Listeria monocytogenes 及 E. coli O157:H7，兼顧微生物安全與品質。
嘻嘻：—電漿技術加氯洗聯手對付青豆上的 Listeria 和 E. coli，非熱加工殺菌又進化一步，保鮮又安全！
Digital twin-centered food safety management systems: A review of IoT, AI, and blockchain integration for bacterial pathogen control¶
Authors: Ismail BB et al. | Journal: Food Res Int | Date: 2026-05-12
DOI: 10.1016/j.foodres.2026.119449
TL;DR: 數位孿生結合IoT、AI及區塊鏈可將食品安全管理從被動事後應對轉為主動即時預防，強化病原菌污染控制效能。
嘻嘻：—數位孿生+區塊鏈監控食品鏈聽起來很酷，如果真能落地，下次 Salmonella 爆發可能早三天被抓到。
Microplastic co-pollution in food systems: interaction mechanisms, migration, removal technologies, and environmental linkages¶
Authors: Feng J et al. | Journal: Food Res Int | Date: 2026-05-14
DOI: 10.1016/j.foodres.2026.119443
TL;DR: 系統回顧微塑膠作為食品系統中共污染物載體，可攜帶微生物、持久性有機物與重金屬，複合毒性機制複雜。
不嘻嘻：—微塑膠帶著細菌、農藥和重金屬一起進入食品鏈，複合毒性還沒搞清楚，但我們每天都在吃。
Towards sustainable serum-free media development from alternative sources for cultivated meat¶
Authors: Sivakumar S et al. | Journal: Food Res Int | Date: 2026-05-13
DOI: 10.1016/j.foodres.2026.119434
TL;DR: 回顧以植物性等永續來源替代動物血清開發無血清培養基用於細胞培養肉，降低成本並改善倫理問題，但規模化仍有挑戰。
嘻嘻：—細胞培養肉走向不用動物血清，永續替代方案百花齊放，未來牛排可能真的不需要牛！
Prevalence, plasmid transmission, and chromosomal integration of blagenes in Salmonella isolated from retail chicken and pork meats in China¶
Authors: Sheng H et al. | Journal: Food Res Int | Date: 2026-05-11
DOI: 10.1016/j.foodres.2026.119421
TL;DR: 中國市售雞豬肉 Salmonella 中ESBL基因（bla）陽性率達10.8%，可透過質體水平轉移傳播，食品安全風險顯著。
不嘻嘻：—中國市場雞豬肉裡的 Salmonella 帶著bla基因四處傳播，ESBL問題從醫院延伸到菜市場，防線節節潰退。
Intra-seafood strain diversity and temporal dynamics of Vibrio parahaemolyticus in a retail stall¶
Authors: Wang N et al. | Journal: Int J Food Microbiol | Date: 2026-05-19
DOI: 10.1016/j.ijfoodmicro.2026.111854
TL;DR: 單一零售海鮮攤3個月WGS追蹤顯示 Vibrio parahaemolyticus 菌株高度多樣且持續替換，提示食品鏈中病原傳播動態極為活躍。
不嘻嘻：—一個海鮮攤就藏了多少株 V. parahaemolyticus，換來換去永遠追不完，夏天吃生蠔的後果自負。
Analysis of foodborne disease outbreak surveillance in the China Mainland 2014-2023¶
Authors: Li T et al. | Journal: Food Microbiol | Date: 2026-05-07
DOI: 10.1016/j.fm.2026.105143
TL;DR: 2014-2023年中國大陸食源性疾病爆發達5萬起、逾1,300死亡，地理差異顯著，夏季高峰，家庭環境為主要發生地。
不嘻嘻：—10年5萬起食源性疾病爆發，中國大陸數字驚人，家庭廚房仍是主戰場，衛教再強也不夠。
Evolution of Salmonella Typhimurium under antibiotics from distinct classes reveals variant-dependent cross-protection against food preservation treatments¶
Authors: García-Penas I et al. | Journal: Food Microbiol | Date: 2026-05-04
DOI: 10.1016/j.fm.2026.105138
TL;DR: Salmonella Typhimurium接觸抗生素後可對熱處理、酸化等食品保存壓力產生交叉耐受性，提示AMR機制可能削弱食品加工安全性。
不嘻嘻：—Salmonella 練了抗藥術，順帶對食品加工殺菌也產生耐受，AMR問題比我們想的還要複雜深遠。
資料來源：PubMed (articles retrieved 2026-05-31)