Daily Journal Digest — 2026-05-28¶
過去 24 小時新增：Transplant ID × 30、One Health × 15、Food Security × 13，共 58 篇。
🔴 Transplant & Opportunistic Infections¶
Outbreak of Wickerhamomyces anomalus (formerly Candida pelliculosa) Bloodstream Infections, Venezuela, 2022-20231¶
Authors: Dolande-Franco M et al. | Journal: Emerg Infect Dis | Date: 2026 May 26
DOI: 10.3201/eid3206.251978
TL;DR: Venezuela 2022–2023 年 8 家醫院出現 110 例 Wickerhamomyces anomalus 血流感染，Caracas 單一 pediatric ICU 佔 82 例，genotyping 支持多起 clonal transmission。
不嘻嘻：兒科加護病房的新生兒爆發真菌感染，臨床守門人壓力山大。
Unraveling the Rectal Virome: Microbial Crosstalk, Immune Modulation, and Clinical Outcomes in People with and Vulnerable to HIV¶
Authors: Bako RS et al. | Journal: Viruses | Date: 2026 Apr 29
DOI: 10.3390/v18050511
TL;DR: Rectal virome 在 PWH 與 MSM 中常見 herpesviruses、CMV、HPV，可能透過 virome-bacteriome-immune crosstalk 影響 HIV 易感性與臨床結果，但證據仍不足。
嘻嘻：終於開始研究直腸病毒組對免疫的調控，雖然目前還在摸索。
Polymorphisms for Defence and Virulence in the Arabidopsis thaliana-Cucumber mosaic virus Interaction Are Expressed in the Host's Native Habitat¶
Authors: Pagán I et al. | Journal: Viruses | Date: 2026 Apr 23
DOI: 10.3390/v18050494
TL;DR: 野外 Arabidopsis thaliana 接種 CMV 後，10 個 genotype 的 virulence、resistance 與 tolerance 差異仍可重現，支持溫室結果可反映 native habitat 中的 host-virus interaction。
嘻嘻：野外研究跟實驗室結果能對上，代表我們沒在象牙塔裡做白工。
Epstein-Barr virus-specific T-cells in pediatric liver transplant recipients¶
Authors: Getsuwan S et al. | Journal: Sci Rep | Date: 2026 May 26
DOI: 10.1038/s41598-026-54471-7
TL;DR: 40 名 pediatric liver transplant 兒童中 7 例（17.5%）發生 EBV infection；術前 EBNA1-specific CD4+/CD8+ T-cells 較低，48 週 IFSR 最高可達 100%。
不嘻嘻：移植後 T 細胞不給力，EBV 就會在那邊蠢蠢欲動等著翻盤。
Long-term evolution of the burden of HIV/AIDS in older adults: a global burden of disease analysis in individuals aged ≥75 years in G7 countries¶
Authors: Sun R et al. | Journal: Front Public Health | Date: 2026
DOI: 10.3389/fpubh.2026.1811915
TL;DR: GBD 1990–2021 資料顯示 G7 ≥75 歲 HIV/AIDS incidence 與 mortality 多數下降，但 prevalence 與 DALYs 在部分國家上升，呈現存活增加與 disability 累積。
不嘻嘻：活得更久，HIV 負擔也更重。
Past Achievements, Present Gaps, and Future Priorities in Pneumocystis jirovecii Research: A Global Bibliometric Analysis¶
Authors: Ortiz B et al. | Journal: Pathogens | Date: 2026 May 14
DOI: 10.3390/pathogens15050530
TL;DR: Scopus 收錄 1916–2025 年 P. jirovecii 文獻 27,396 篇，2001–2025 較 1975–2000 增加 58.9%，研究重心轉向 molecular diagnostics 與 non-HIV immunosuppression。
不嘻嘻：寫了半個世紀的論文，PJP 的診斷跟治療居然還是欠資源。
Molecular Mechanisms of Mucormycosis Pathogenesis: Host-Pathogen Interactions and Immune Evasion¶
Authors: Alanazi A et al. | Journal: Pathogens | Date: 2026 May 12
DOI: 10.3390/pathogens15050522
TL;DR: Mucormycosis 死亡率仍超過 50%；CotH-GRP78、iron acquisition、mucoricin 與 PAMP masking 等機制，解釋 Mucorales endothelial invasion 與 immune evasion。
不嘻嘻：毛黴菌又是搶鐵又是逃避免疫，根本是真菌界的生存大師。
Clinical Characteristics and Outcomes of Cytomegalovirus DNAemia in Non-HIV-Infected and Non-Transplant Patients: A Propensity Score-Matched Analysis¶
Authors: Salter I et al. | Journal: Pathogens | Date: 2026 May 01
DOI: 10.3390/pathogens15050492
TL;DR: TriNetX 納入 1,123 名 NHNT CMV DNAemia 成人，63% 有 neoplasms；30 天住院率 35%、死亡率 14%，respiratory failure、malnutrition、hypotension 等與 90 天死亡相關。
不嘻嘻：非移植患者一旦 CMV 陽性死亡率就破表，脆弱族群真的傷不起。
Transfusion-transmitted cytomegalovirus infection in the era of universal leukoreduction and pathogen inactivation: a contemporary review¶
Authors: Kirupanantha Rajan P et al. | Journal: Lab Med | Date: 2026 Apr 03
DOI: 10.1093/labmed/lmag031
TL;DR: Universal leukoreduction 可移除 >99.9% leukocytes、達 <5×10^6/unit；transfusion-transmitted CMV 已屬罕見，但新生兒與 transplant recipients 仍需監測殘餘風險。
嘻嘻：輸血感染 CMV 幾乎絕跡，這大概是血液安全史上的一大勝利。
Predicting antifolate resistance in the unculturable fungal pathogen Pneumocystis jirovecii¶
Authors: Rouleau FD et al. | Journal: PLoS Genet | Date: 2026 May 27
DOI: 10.1371/journal.pgen.1012163
TL;DR: P. jirovecii DHFR 的 DMS 結合 biophysical modeling 與 random forest，可預測 MTX/TMP resistance；resistance mutation 受 enzyme function 保留限制。
不嘻嘻：雖然能用功能掃描預測抗藥性，但藥物選擇還是少得可憐。
Adoptive T-Cell Immunotherapy¶
Authors: Gottschalk S et al. | Journal: Curr Top Microbiol Immunol | Date: 2026 May 28
DOI: 10.1007/82_2026_345
TL;DR: EBVSTs 對 PTLD 尤其 HSCT 後療效佳且 toxicity 低；third-party off-the-shelf 產品已於歐洲核准，type 2 latency tumors 仍受 antigen expression 與 tumor microenvironment 限制。
嘻嘻：現成的 T 細胞療法能隨取隨用，這對 PTLD 患者是真福音。
Unsupervised Immune Profiling Identifies Distinct Post-Transplant T-Cell Clusters Associated with Kidney Allograft Function¶
Authors: Vagiotas L et al. | Journal: Med Sci (Basel) | Date: 2026 May 04
DOI: 10.3390/medsci14020238
TL;DR: 112 名 kidney transplant recipients 於 12 個月 flow cytometry 分成 CD8-skewed、innate-like cytotoxic、CD4-dominant 三群，T-cell cluster 與第一年 eGFR/creatinine trajectory 相關。
不嘻嘻：CD8 比例偏高預示腎功能不佳，看來免疫平衡比什麼都重要。
Beyond CD4: Posterior segment findings and virologic-immunologic predictors in highly active antiretroviral therapy-naïve HIV patients¶
Authors: Hayat SC et al. | Journal: Indian J Ophthalmol | Date: 2026 Jun 01
DOI: 10.4103/IJO.IJO_1957_25
TL;DR: 124 名 ART-naïve PLWH 中 29% 有 posterior segment involvement，最常見 CMV retinitis；log10 CMV plasma load 為最強 predictor（OR 1.630，P=0.003）。
不嘻嘻：三成未治療患者眼部中招，CMV viral load預測視力風險最關鍵。
Toward precision anti-biofilm therapy for Candida: a translational perspective¶
Authors: Tuan DA et al. | Journal: Future Microbiol | Date: 2026 May 27
DOI: 10.1080/17460913.2026.2678109
TL;DR: PABT 被定位為 Candida biofilm translational framework：Tier 1 強調 species ID、susceptibility、source control；biofilm phenotype、biomarker、nano-delivery 仍屬研究階段。
不嘻嘻：唸了這麼多年生物膜精準治療，結果臨床應用還在實驗室階段。
Deciphering the role of the Sch9 serine/threonine kinase in Scedosporium apiospermum¶
Authors: Kabbara S et al. | Journal: Front Fungal Biol | Date: 2026
DOI: 10.3389/ffunb.2026.1820509
TL;DR: Scedosporium apiospermum Δsch9 顯著降低 fitness 與 hyphal development，增加 oxidative/cell wall stress 敏感性，並削弱抵抗 macrophage ingestion 與 killing 的能力。
不嘻嘻：這種冷門真菌連激酶都長得這麼有侵略性，治療難度又增加了。
Interferon-Inducible Gene Upregulation Correlates With Successful Viral Clearance in Patients With BK Polyomavirus-Associated Nephropathy¶
Authors: Omic H et al. | Journal: Kidney Int Rep | Date: 2026 Jul
DOI: 10.1016/j.ekir.2026.106551
TL;DR: 30 例 biopsy-proven BKPyVAN 中，6 與 12 個月 BKPyV-DNAemia clearance 皆為 40%；ISG15、IFI27、IFIT1、IFITM1 上調預測 clearance，12 個月 AUC 0.91–0.97。
嘻嘻：看到干擾素相關基因上調能清除病毒，這點暫時的腎損還算值得。
A comprehensive mechanistic multicellular model of the human immune system spanning 11 diseases¶
Authors: Moore R et al. | Journal: Front Immunol | Date: 2026
DOI: 10.3389/fimmu.2026.1732556
TL;DR: 以 449 篇 human experimental data 建構 immune model，涵蓋 88 種 immune cell type、37 secretory factors、1,450 interactions；38 項 validation 與文獻一致率 75%–90%。
嘻嘻：一個模型能跨 11 種疾病，這 AI 建模要是成真，收病人就穩了。
Assessment of PPD Conversion Rate in Patients Receiving Tumor Necrosis Factor-alpha Inhibitor Drugs¶
Authors: Meidani M et al. | Journal: Iran J Pathol | Date: 2026
DOI: 10.22034/ijp.2026.2076748.3574
TL;DR: 60 名 anti-TNF 使用者追蹤 1 年，6 例（10%）PPD conversion，未見 active TB；psoriatic arthritis 唯一顯著相關因子（P=0.03）。
不嘻嘻：用了抗 TNF 藥物後一成患者轉陽性，潛伏結核真是日常陰影。
Candicidal Effect of a Nanoemulsion Based on the Essential Oil of the Medicinal Plant Haplopappus foliosus: Role of Main Compounds in Yeast Inhibition¶
Authors: Madrid A et al. | Journal: Pharmaceuticals (Basel) | Date: 2026 May 12
DOI: 10.3390/ph19050759
TL;DR: Haplopappus foliosus essential oil 以 terpinen-4-ol 27.27% 與 α-bisabolol 10.40% 為主；α-bisabolol 對 C. albicans MIC 16 µg/mL，nanoemulsion 48 小時達 fungicidal effect。
嘻嘻：藥用植物萃取的奈米乳劑對念珠菌有效，天然的果然還是最香。
Analytical Performance and Inter-Method Agreement of a Laboratory-Developed CMV qPCR Assay in Clinical Plasma Samples¶
Authors: Aral M et al. | Journal: Microorganisms | Date: 2026 May 15
DOI: 10.3390/microorganisms14051127
TL;DR: 100 件 plasma 比較 laboratory-developed CMV qPCR 與 Roche Cobas CMV，LoD95 為 63.8 copies/µL；低 CMV DNA level 的 quantitative monitoring 需謹慎解讀。
不嘻嘻：低病毒量時自建方法就不太準，這種時候還是花錢買商檢穩一點。
Inhibitors of the FASII Metabolic Pathway in Toxoplasma gondii: Advances and Therapeutic Perspectives¶
Authors: Castillo-Villanueva CJ et al. | Journal: Microorganisms | Date: 2026 May 09
DOI: 10.3390/microorganisms14051072
TL;DR: Toxoplasma gondii FASII 位於 apicoplast 且哺乳動物宿主缺乏，現有 inhibitor 證據支持其作為較 selective toxoplasmosis therapeutic target，但 chronic phase efficacy 仍待突破。
不嘻嘻：標靶雖然選得好，但臨床驗證還遙遙無期，弓蟲還是很難搞。
Decoding CAPA: A Comparative Study of AspICU, ISHAM, and EORTC Criteria in Critical COVID-19 Patients Requiring Mechanical Ventilation¶
Authors: Taleb C et al. | Journal: Microorganisms | Date: 2026 Apr 27
DOI: 10.3390/microorganisms14050978
TL;DR: 405 名 mechanical ventilation COVID-19 ICU 病人中，CAPA incidence 依 criteria 差異很大：EORTC/MSG 6.1%、AspICU 9.7%、ISHAM 15.1%；probable CAPA ICU mortality 約 76%。
不嘻嘻：診斷標準各說各話，抓不到 CAPA 就只能看著死亡率升高。
Roles of Indole and Its Derivative in Modulating E. coli-Candida albicans Biofilm Formation¶
Authors: Ma YQ et al. | Journal: Int J Mol Sci | Date: 2026 May 16
DOI: 10.3390/ijms27104478
TL;DR: E. coli tnaAΔ 使 mono-species biofilm 降 12%，且失去促進 C. albicans biofilm 的 1.7-fold 效果；indole 與 IAA 參與 bacterial-fungal mixed biofilm signaling。
嘻嘻：讓細菌去搞定真菌生物膜，微生物界這種「內鬥」我最愛看。
Temporal Trends of Candida Species in Healthcare-Associated Infections in Intensive Care Units in Taiwan¶
Authors: Hsiao CC et al. | Journal: Medicina (Kaunas) | Date: 2026 Apr 24
DOI: 10.3390/medicina62050814
TL;DR: 台灣 ICU HAI surveillance 2018–2023 顯示 Candida 比例由 15.13% 升至 16.74%，主要由 NACs 6.84% 升至 7.91% 驅動，Efm 同期升至 11.11%。
不嘻嘻：台灣 ICU 非白念珠菌感染持續上升，又是濫用抗生素的鍋。
Global Epidemiology of Post-Transplant Lymphoproliferative Disorder (PTLD) in Hematopoietic Stem Cell Transplantation (HSCT): A Systematic Review and Meta-Analysis of Incidence, Subtypes, Risk Factors, and Beyond¶
Authors: Khandker SS et al. | Journal: J Clin Med | Date: 2026 May 18
DOI: 10.3390/jcm15103867
TL;DR: 39 項 HSCT 研究 meta-analysis 顯示 PTLD pooled incidence 5.6%（95% CI 5.0–6.3），排除 outlier 後升至 12.4%；allogenic HSCT 與 HLA mismatch 是主要風險脈絡。
不嘻嘻：移植後 PTLD 發生率不低，HLA 錯配簡直是埋下定時炸彈。
Clinical Characteristics, Microbiological Sources, and Outcomes of Candida-Positive ICU Cultures in Critically Ill Adults¶
Authors: Yalçınkaya E et al. | Journal: J Clin Med | Date: 2026 May 12
DOI: 10.3390/jcm15103710
TL;DR: 349 名 ICU Candida-positive culture 病人，28 天死亡率 59.0%、ICU mortality 65.9%；blood/sterile-site isolation 的 ICU mortality 較高（79.2% vs 63.5%）。
不嘻嘻：單靠評分表抓念珠菌太天真，一旦在無菌部位分離到就真的不妙。
Knowledge, Psychological Distress, and Medication Beliefs Among Tuberculosis Patients in Southwest China: A Mediation Analysis¶
Authors: Zheng Y et al. | Journal: Healthcare (Basel) | Date: 2026 May 11
DOI: 10.3390/healthcare14101298
TL;DR: 中國西南TB 橫斷研究顯示 TB knowledge 透過 psychological distress 影響 medication beliefs，indirect effect 0.014（95% CI 0.001–0.033），佔 total effect 37.12%。
不嘻嘻：衛教做得再好，患者心情不好也會讓療效歸零，心病還須心藥醫。
Insights into Canine Idiopathic Rhinitis from a Prospective Study: A Multimodal Diagnostic Perspective¶
Authors: Rösch S et al. | Journal: Animals (Basel) | Date: 2026 May 08
DOI: 10.3390/ani16101438
TL;DR: 46 隻慢性 nasal discharge 犬中 13 隻為 idiopathic rhinitis；allergen-specific IgE 在各組皆常見，與 sinusitis、turbinate destruction、culture bacteriology 無診斷或預測價值。
嘻嘻：原來狗狗也會有特發性鼻炎，這種排除診斷法真的很有我們風格。
Clinical Determinants of 30-Day Mortality in Candidemia: Antifungal Susceptibility and Treatment Patterns in a 10-Year Cohort¶
Authors: Yılmaz Nakir İ et al. | Journal: Antibiotics (Basel) | Date: 2026 Apr 28
DOI: 10.3390/antibiotics15050438
TL;DR: 391 例 candidemia 十年 cohort 中 30 天死亡率 54%，non-albicans Candida 佔 62.7%；年齡、ICU admission、septic shock、未移除 central venous catheter、leukocytosis、thrombocytopenia 為獨立 predictor。
不嘻嘻：五成以上的死亡率，念珠菌血症患者的中心靜脈管一定要拔。
Guidance for Chest-CT in Children and Adults with Cystic Fibrosis: A European Perspective (Part 2: Special Situations/Respiratory Complications)¶
Authors: Fayon M et al. | Journal: Respir Med | Date: 2026 May 25
DOI: 10.1016/j.rmed.2026.108911
TL;DR: ECFS-CTN Delphi consensus 支持 CF 病人在 haemoptysis、Allergic Bronchopulmonary Aspergillosis、NTM-positive cultures 時使用 chest CT，最終仍由照護團隊判斷必要性。
嘻嘻：囊狀纖維化患者的影像指引終於明確了，不用再在那邊瞎猜。
🟢 One Health / Zoonoses¶
Characterization of inner capsid σA protein as a virulence factor of the pteropine orthoreovirus¶
Authors: Harima H et al. | Journal: PLoS Pathog | Date: 2026 May 26
DOI: 10.1371/journal.ppat.1014252
TL;DR: PRV mouse model 顯示 S1/S2 segment 影響 virulence；σA protein Ser-46 是關鍵 determinant，出現在 human、monkey、bat fly strains，可能與跨物種 transmission 相關。
不嘻嘻：正呼腸孤病毒換個氨基酸就可能跨種傳播，大自然真的很會。
The Hungate1000 prokaryotic culture collection encodes a wide variety of bacteriocins¶
Authors: Hourigan D et al. | Journal: mSystems | Date: 2026 May 27
DOI: 10.1128/msystems.00195-26
TL;DR: Hungate1000 中 410 個 rumen prokaryotes 發現 408 個 novel bacteriocin gene clusters、分布於 308 genomes；putative bacteriocin frequency 逾 30%，納入 ranthipeptides 等可達約 70%。
嘻嘻：瘤胃細菌庫藏著這麼多抗菌胜肽，看來新抗生素的希望在牛胃。
Odocoileus virginianus PRNP sequencing reveals AF (Q95G96/H95G96) advantage over AC (Q95G96/Q95S96) against chronic wasting disease¶
Authors: London EW et al. | Journal: Vet Res | Date: 2026 May 26
DOI: 10.1186/s13567-026-01752-8
TL;DR: 重新設計 primer 後於 586 隻原判 homozygous deer 中找出 128 隻 heterozygotes；PrP C/F variant 對 CWD susceptibility 最低（OR 0.03，P<0.001）。
嘻嘻：利用基因分型就能預測白尾鹿的抗病性，精準醫療也要下鄉。
Structures of New World mammarenavirus glycoproteins as targets for antibody-mediated neutralization¶
Authors: Taylor LJ et al. | Journal: J Virol | Date: 2026 May 27
DOI: 10.1128/jvi.01626-25
TL;DR: New World mammarenavirus GPC 由 GP1、GP2、SSP 組成並透過 TfR1 介導 entry；近十年 structural biology 揭示 receptor binding 與 neutralizing antibody targets。
嘻嘻：arena 病毒結構被摸透了，抗體治療與疫苗開發總算有方向。
Going wild: prioritizing experimental models of rodent-borne viruses to decode zoonotic spillover and pandemic risk¶
Authors: Honce R et al. | Journal: J Virol | Date: 2026 May 27
DOI: 10.1128/jvi.01751-25
TL;DR: Rodent-borne mammarenaviruses 與 orthohantaviruses 的 reservoir persistence 與 spillover 需結合 field 與 laboratory model；作者主張優先建立更自然且可轉譯的 experimental infection models。
嘻嘻：把野外模型跟實驗室結合，終於不用再盲目擔心人畜共通傳染。
Infectome Landscape of Rodents and Shrews in Guangdong Province Reveals Diverse Pathogens with Zoonotic Potential in Wildlife¶
Authors: Lin Y et al. | Journal: Viruses | Date: 2026 May 21
DOI: 10.3390/v18050584
TL;DR: 廣東42 隻 rodents、16 隻 shrews 共 227 tissue samples 的 meta-transcriptomics 找到 34 viral families；23 種 mammalian viruses 中 15 種被 machine learning 評為 high risk。
不嘻嘻：廣東野生動物帶這麼多威脅病毒，我們離下一次大流行不遠。
Aerosol Inhalation of a Recombinant H7N9 Hemagglutinin Antigen Elicits Systemic and Mucosal Immune Responses in Mice¶
Authors: Hou Z et al. | Journal: Viruses | Date: 2026 May 21
DOI: 10.3390/v18050579
TL;DR: X33CLS-H7 在 mice 中 i.m. 兩劑 HI GMT 達 1:1622、mean log10 NT50 4.62；高劑量 nebulized 四劑亦誘發 serum 與 BALF HA7-specific IgG/IgA，未見明顯 toxicity。
嘻嘻：吸入式疫苗比打針更方便，還能激發黏膜免疫，怕針者的救星。
The Largest Outbreak of Acute Gastroenteritis of Mixed Norovirus Genogroups in the Coast of São Paulo State, Brazil¶
Authors: Carmona RC et al. | Journal: Viruses | Date: 2026 May 13
DOI: 10.3390/v18050555
TL;DR: São Paulo coast 2024-12-29 至 2025-03-06 通報 55 起 AGE outbreaks、755 例，另有 >76,000 次就診；NoV 陽性率 54%，GII.17[P17] 佔 48%。
不嘻嘻：諾羅病毒在巴西海岸大爆發，這種病毒的變異速度真的太卷了。
Bat-Borne Viruses and Pandemic Risk: Could Europe Be an Emergence Hotspot?¶
Authors: Skowron K et al. | Journal: Viruses | Date: 2026 May 02
DOI: 10.3390/v18050535
TL;DR: Bat-borne RNA viruses 約 80% 來自 Vespertilionidae、Rhinolophidae、Pteropodidae；Europe 需持續監測 coronavirus、filovirus、paramyxovirus 的 genetic change 與 spillover risk。
不嘻嘻：歐洲蝙蝠病毒監測刻不容緩，這種隨時會跨種的風險太讓人焦慮。
Emergence and Evolution of Triple Reassortant Highly Pathogenic Avian Influenza A(H5N1) Virus, Argentina, 2025¶
Authors: Benedetti E et al. | Journal: Viruses | Date: 2026 Apr 30
DOI: 10.3390/v18050525
TL;DR: Argentina 2025 年出現 novel triple reassortant A(H5N1)，含 Eurasian、North American、South American lineage segments；HA T204K/P251S 與 PB2 I292M 提示持續 adaptation。
不嘻嘻：H5N1 在阿根廷瘋狂重組演化，禽流感真的打算跟人類拼到底。
Pathological, Immunohistochemical, and Bacteriological Characterization of Salmonellosis in Bearded Dragons (Pogona vitticeps)¶
Authors: Dorsch MA et al. | Journal: Pathogens | Date: 2026 Apr 22
DOI: 10.3390/pathogens15050457
TL;DR: 6 例 bearded dragon salmonellosis 以 fibrinonecrotizing enterocolitis 83.3% 與 hepatitis 66.7% 為主；cultures 包含 S. houtenae、Rissen、Cotham、S. diarizonae。
不嘻嘻：寵物蜥蜴也會得沙門氏菌性腸炎，這下又要多提醒飼主勤洗手。
Protective Effect of Escherichia coli Nissle 1917 on Salmonella typhimurium Infection by Regulating Intestinal Flora¶
Authors: Li ZJ et al. | Journal: Microorganisms | Date: 2026 May 20
DOI: 10.3390/microorganisms14051155
TL;DR: EcN 預處理 mice（n=15/group）可提高 Peyer’s patch mature dendritic cells，降低 Salmonella typhimurium 後 spleen/liver live bacteria 與病理變化，並改善 survival。
嘻嘻：用益生菌來對抗沙門氏菌感染，讓菌相自己去重塑免疫防線。
Detection of Bovine Brucellosis Antibodies in Serum and Milk Using Quantum Dot Microspheres Immunochromatographic Assay¶
Authors: Chen M et al. | Journal: Microorganisms | Date: 2026 May 08
DOI: 10.3390/microorganisms14051057
TL;DR: Brucella QDMs-ICA 對 bovine serum 與 milk sensitivity 分別約 0.98、1.56 IU/mL；150 serum 與 80 milk 與 ID-VET kit coincidence rates 為 97.3%、96.3%。
嘻嘻：牛奶也能快速驗出布氏桿菌抗體，量子點技術讓檢測變親民。
Genomic Epidemiology of Foodborne Salmonella in Colombia (2002-2009): Emergence of Novel IncHI1 and IncI1 Plasmids Harboring Metal and Multi-Drug Resistance Clusters¶
Authors: Li M et al. | Journal: Antibiotics (Basel) | Date: 2026 May 18
DOI: 10.3390/antibiotics15050511
TL;DR: Colombia 2002–2009 年 90 株 foodborne Salmonella 中 45.6% 有 AMR、7 株 MDR；novel IncHI1 229,037 bp plasmid 同帶 metal 與 antibiotic resistance clusters。
不嘻嘻：連食源性沙門氏菌都帶金屬抗性質體了，我們以後真的沒藥可用。
Mobile Genetic Elements Associated with Antimicrobial Resistance Across One Health Interfaces in Africa: A Systematic Review and Meta-Analysis¶
Authors: Hassen KA et al. | Journal: Antibiotics (Basel) | Date: 2026 Apr 30
DOI: 10.3390/antibiotics15050456
TL;DR: Africa MGE-AMR systematic review 納入 109 項研究，plasmids 71.7%、integrons 54.8% 最常見；pooled AMR prevalence 94%（95% CI 85–98），heterogeneity I2 97.4%。
不嘻嘻：非洲的抗藥基因全靠質體在跑，這種全球化的傳播速度不嘻嘻。
🟡 Food Security / Food Safety¶
Agricultural intensification, microbial homogenization and loss of rare microbiota¶
Authors: Banerjee S et al. | Journal: Nat Rev Microbiol | Date: 2026 May 26
DOI: 10.1038/s41579-026-01315-w
TL;DR: Agricultural intensification 造成 microbial homogenization，尤其降低 rare taxa diversity、抑制 beneficial microorganisms 並促進 pathogenic taxa，可能威脅 agro-ecosystem function 與 food security。
不嘻嘻：農業太集約化讓微生物同質化，稀有菌群流失對生態真的是浩劫。
Evaluating the effect of Iron biofortification on nutraceutical and aromatic profiles of cereal grains: A case study of pearl millet¶
Authors: Abaker HMA et al. | Journal: Food Chem | Date: 2026 May 18
DOI: 10.1016/j.foodchem.2026.149661
TL;DR: Pearl millet iron biofortification 鑑定 118 種 nutraceuticals、26 種 volatile compounds；total amino acids 增 22.67%、volatile compounds 增 41.73%、tannins 降 15.73%。
嘻嘻：鐵強化還能讓小米變好吃，這種兼顧營養與口感的改良最有愛。
Broad-spectrum antibody based colorimetric immunoassay for highly sensitive on-site quantitative detection of thirteen fluoroquinolones residues in aquatic products¶
Authors: Cai Z et al. | Journal: Food Chem | Date: 2026 May 24
DOI: 10.1016/j.foodchem.2026.149713
TL;DR: Broad-spectrum antibody colorimetric immunoassay 可於 10 分鐘偵測 13 種 FQs residues，肉眼 LOD 2.0–4.0 µg/L、quantitative LOD 0.83 µg/L，適用 shrimp、tilapia、bullfrog。
嘻嘻：十分鐘就能抓到水產品的fluoroquinolones殘留，黑心商人的噩夢來了。
AI-driven personalization of food systems: From precision nutrition to climate-resilient supply chains¶
Authors: Zheng L et al. | Journal: NPJ Sci Food | Date: 2026 May 26
DOI: 10.1038/s41538-026-00901-9
TL;DR: AI 可整合 multi-omics、real-time nutrition data、climate modeling 與 dynamic logistics，支援 precision nutrition 與 resilient supply chains；data silos、algorithmic bias、technology gaps 仍是限制。
嘻嘻：用 AI 同時解決營養與氣候問題，雖然有資料孤島但前景看好。
Isolation and characterization of Lactobacillus plantarum LP2301 from bovine milk: acid and bile tolerance, antibacterial activity, and genomic safety evaluation¶
Authors: Fang H et al. | Journal: NPJ Sci Food | Date: 2026 May 27
DOI: 10.1038/s41538-026-00908-2
TL;DR: Bovine milk isolate Lactobacillus plantarum LP2301 可耐 pH 2.5 與 0.3% bile salt，genome 含 plantaricin gene clusters plnE/plnF 且無 hemolysis，具 bacteriocin-like antimicrobial potential。
嘻嘻：從牛奶裡挑出的益生菌還帶抗菌胜肽，這種天然保護力超有潛力。
Strain-dependent differences in the capacity of peste des petits ruminants virus to infect antigen-presenting cells¶
Authors: Bouziane A et al. | Journal: J Virol | Date: 2026 May 27
DOI: 10.1128/jvi.00294-26
TL;DR: Goat/sheep MoDCs 對兩株 PPRV 高 permissive，48 hpi viral titers 達 104–105 TCID50/mL；cattle MoDCs 無可測 titer，goat MoMs 對低 virulence strain 呈 semi-permissive infection。
嘻嘻：搞清楚為什麼牛不會被 PPRV 感染，這就是破解毒力的關鍵。
Bayesian Multivariate Modelling of Lone Star (Amblyomma americanum) Tick Life Stage Abundance and Temporal Trends to Inform Public Health Risk in Virginia¶
Authors: Lephoto T et al. | Journal: Int J Environ Res Public Health | Date: 2026 May 15
DOI: 10.3390/ijerph23050660
TL;DR: Virginia 2009–2018 Amblyomma americanum 資料顯示 adult tick 5–6 月、nymph 6–7 月、larvae 8 月達高峰，wooded habitats 較 grassy areas abundance 高。
不嘻嘻：弗吉尼亞的蜱蟲在夏天最瘋狂，看來出門郊遊的風險又高了。
AI-IoT driven system for agricultural pest outbreak risk prediction¶
Authors: Nyakuri JP et al. | Journal: Sci Rep | Date: 2026 May 26
DOI: 10.1038/s41598-026-54478-0
TL;DR: FAW AI-IoT 系統以 Tiny-MobileNet-SE 達 98.6% accuracy、98.5% F1-score，模型 0.72 MB、Raspberry Pi 5 latency 80 ms，可支援田間 outbreak risk prediction。
嘻嘻：物聯網加 AI 預測農作物蟲害，農業生產終於能告別靠天吃飯。
A method for improving winter wheat mapping accuracy based on multi-temporal feature fusion and stacking ensemble learning¶
Authors: Tao W et al. | Journal: Sci Rep | Date: 2026 May 26
DOI: 10.1038/s41598-026-52843-7
TL;DR: Sentinel-2 multi-temporal feature fusion 加 stacked ensemble learning 用於 Jiangsu winter wheat mapping，2021–2023 OA 為 95.31%、94.83%、94.74%，Kappa 約 0.93。
嘻嘻：小麥地圖準確度高達 94%，這對糧食安全監測簡直是大補帖。
Growth Enhancement of Salmonella by Tungstate Treatment¶
Authors: Anderson RC et al. | Journal: Pathogens | Date: 2026 Apr 29
DOI: 10.3390/pathogens15050478
TL;DR: 50 mM sodium tungstate 在 pure culture 反而促進 Salmonella Newport、Dublin、Typhimurium 生長；100 mM tungstate 於 rumen microbiota 中也增加 S. Newport、E. coli 與 lactic acid bacteria。
不嘻嘻：鎢酸鹽居然促進沙門氏菌生長，這下子某些工業污染區麻煩了。
Schizophyllum commune Exopolysaccharides Reduce Salmonella Gut Epithelial Invasion and Activate Macrophages Towards M1-Polarization¶
Authors: Tantibhadrasapa A et al. | Journal: Int J Mol Sci | Date: 2026 May 16
DOI: 10.3390/ijms27104476
TL;DR: Schizophyllum commune EPs 對 Salmonella 無直接 antimicrobial effect，但可降低 T84 gut epithelial invasion，並促進 RAW264.7 macrophage M1-polarization、減少 intracellular burdens。
嘻嘻：用裂褶菌多醣活化巨噬細胞，這種不直接殺菌卻增強防禦的思路好。
Harnessing the Natural Acidity of Raw Passion Fruit Juice for Pathogen Inactivation in Developing Countries¶
Authors: Yepez X et al. | Journal: Foods | Date: 2026 May 19
DOI: 10.3390/foods15101799
TL;DR: Passion fruit juice pH 2.9、5°C 下，S. Typhimurium 與 E. coli 8 小時達 5-log reduction，L. monocytogenes 需 24 小時；pH 3.9 則明顯延緩 inactivation。
嘻嘻：百香果汁的天然酸度就能滅菌，開發中國家的低成本消殺妙招。
Selective Carbohydrate Modulation Enhances BLIS-Mediated Bioprotection Against Multidrug-Resistant Foodborne Pathogens During Vegetable Fermentation¶
Authors: Meidong R et al. | Journal: Curr Microbiol | Date: 2026 May 26
DOI: 10.1007/s00284-026-04975-2
TL;DR: IPC 促進 Le. mesenteroides AHL9a 24 小時達 8.91 log CFU/mL 並提高 BLIS；mustard green fermentation 第 10 天 LAB 達 7.56–7.78 log CFU/g，且 coliforms 被清除。
嘻嘻：用碳水化合物調控來抑制抗藥菌，發酵食品的保護力更上一層樓。
資料來源：PubMed (articles retrieved 2026-05-28)