Daily Journal Digest — 2026-05-26¶
過去 24 小時新增:Transplant ID × 20、One Health × 10、Food Security × 10,共 40 篇。
⭐ 今日亮點¶
- The risk of venous thromboembolism in kidney transplant recipients is enhanced following a cytomegalovirus infection
15,433例多中心隊列首次量化腎移植後CMV病毒血症的VTE風險(HR 1.61),有症狀者更達HR 2.00,臨床意義直接。 - Sputum scarcity and associated factors in people undergoing tuberculosis testing in South Africa, Uganda, India, and the Philippines
高影響力期刊(IF 9.6)四國研究量化TB篩查中13%患者無法排痰,直接支持非痰液檢驗的優先研發。 - Transmission of severe fever with thrombocytopenia syndrome virus from a dog to humans and a cat in a household cluster
首報SFTS病毒家庭叢聚多向傳播(狗→人→貓),台灣SFTS流行區伴侶動物監測政策參考依據。 - Hantavirus seroprevalence and associated factors for exposure in south-central Uganda
高影響力期刊(IF 8.4)首次量化烏干達Orthohantavirus 7.4%血清盛行率,揭示長期被忽視的人畜共通傳播負擔。 - Special pathogen infections presenting with neck mass as the initial manifestation
亞太地區抗IFN-γ autoantibody免疫缺陷合併TM/NTM頸部腫塊案例系列,高度貼近台灣感染科臨床現實。
🔴 Transplant & Opportunistic Infections¶
Sputum scarcity and associated factors in people undergoing tuberculosis testing in South Africa, Uganda, India, and the Philippines: an analysis of cross-sectional observational data¶
Authors: Nwamba WV et al. | Journal: EClinicalMedicine | Date: 2026-05-13
DOI: 10.1016/j.eclinm.2026.103977
TL;DR: 四國橫斷研究顯示13%疑似肺結核患者無法自行排痰,女性及培養陰性者風險更高;痰液誘導不影響Xpert Ultra靈敏度,支持非痰液檢驗優先發展。
不嘻嘻:—每七個要查TB的人就有一個吐不出痰,數字很誠實,但也很讓人頭痛。
Granuloma Drama¶
Authors: Calvert S et al. | Journal: Clin Infect Dis | Date: 2026-05-25
DOI: 10.1093/cid/ciag221
Special pathogen infections presenting with neck mass as the initial manifestation¶
Authors: He J et al. | Journal: Front Cell Infect Microbiol | Date: 2026-05-08
DOI: 10.3389/fcimb.2026.1767591
TL;DR: 廣西13例具抗interferon-γ自體抗體患者以頸部腫塊為首發表現,Talaromyces marneffei及NTM均有,mNGS與培養各司其職,確診中位時間5個月。
嘻嘻:—抗IFN-γ autoantibody免疫缺損在東南亞漸受重視,提醒我們免疫缺陷不只HIV!
Artesunate repurposing for cytomegalovirus management: a systematic review of efficacy, mechanisms, and perspectives¶
Authors: Zhang H et al. | Journal: Front Cell Infect Microbiol | Date: 2026-05-07
DOI: 10.3389/fcimb.2026.1815679
TL;DR: Artesunate系統性回顧(46篇)顯示對CMV有效且無交叉抗藥性,但半衰期短、臨床證據仍不足,需更多隨機試驗佐證其移植後應用。
嘻嘻:—瘧疾藥打CMV的瘋狂點子,居然看起來有點道理!瘋狂科學家能量。
Invasive Fusariosis: A Retrospective Case Series Evaluating In Vitro Minimum Inhibitory Concentrations and Clinical Response¶
Authors: Kovac V et al. | Journal: Open Forum Infect Dis | Date: 2026-05-07
DOI: 10.1093/ofid/ofag248
TL;DR: 21例侵襲性fusariosis回顧:94%三唑類MIC≥4 μg/mL,但triazole±terbinafine仍達76%十二週存活率,說明體外MIC高不等於臨床失敗。
不嘻嘻:—MIC幾乎全部破表但還能活,感覺在跟抗黴菌治療的物理定律對賭,膽子很大。
PCR Fluorescent Probe-based Detection of Aspergillus Spp., Cryptococcus neoformans, and Pneumocystis jirovecii¶
Authors: Zou W et al. | Journal: J Vis Exp | Date: 2026-05-08
DOI: 10.3791/68819
TL;DR: 發表一套痰液多重螢光PCR流程可同步偵測Aspergillus、Cryptococcus neoformans及Pneumocystis jirovecii,附標準操作步驟與判讀閾值,適合臨床推廣。
嘻嘻:—三個強敵一管搞定,臨床診斷的省時神器!
Early Posttransplant Lymphoproliferative Disorder and Cryptosporidiosis After Liver Transplantation¶
Authors: Hakamifard A et al. | Journal: Case Rep Med | Date: 2026-05-23
DOI: 10.1155/carm/5215414
TL;DR: 肝臟移植後同時發生Cryptosporidium腸炎與早發性PTLD(彌漫大B細胞淋巴瘤),rituximab後仍死亡,提醒移植後持續腹瀉需納入PTLD鑑別診斷。
不嘻嘻:—一個病人把感染科和血液腫瘤科的噩夢同時集滿,太不公平了。
Neurological manifestations in Wiskott-Aldrich syndrome: a systematic review¶
Authors: Raccagni NG et al. | Journal: Front Immunol | Date: 2026-05-07
DOI: 10.3389/fimmu.2026.1829058
TL;DR: WAS系統性回顧32例:神經病變分出血、免疫媒介、感染(JC virus/PML為主)及腫瘤(CNS淋巴瘤/PTLD)四類,整體死亡率59.4%,感染及腫瘤型預後最差。
不嘻嘻:—WAS神經問題分四路夾擊且每路都要命,這篇算是罕見疾病的悲傷全景圖。
Dynamic Reprogramming of Fungal Cell Walls Underlies Germination and Immune Exposure in Zygomycetous Fungal Pathogens¶
Authors: Gautam I et al. | Journal: bioRxiv | Date: 2026-05-17
DOI: 10.64898/2026.05.12.724644
TL;DR: 毛黴菌萌發過程中細胞壁由β-1,3-glucan轉為chitin-chitosan為主,此重塑強化中性球辨識,為mucormycosis免疫逃脫機制研究提供分子基礎。
嘻嘻:—基礎科學找到抗黴新靶點,細胞壁重塑機制被抓包,值得期待後續藥物開發!
Solitary Cavitary Right Upper Lobe Lesion Revealing Disseminated Cryptococcosis in a Kidney Transplant Recipient: A Diagnostic Challenge¶
Authors: Worku D et al. | Journal: Case Rep Pulmonol | Date: 2026-05-20
DOI: 10.1155/crpu/5586947
TL;DR: 腎移植受者以單一空洞性肺結節表現,影像疑似惡性腫瘤,後確診為播散性cryptococcosis合併CNS侵犯,提醒移植後肺空洞需廣泛鑑別。
不嘻嘻:—腫瘤?其實是黴菌!這種診斷反轉在免疫抑制患者身上真的讓人不得不提高警覺。
Incidence of BK Virus in HIV-positive Kidney Transplant Recipients: Case Series From South Africa¶
Authors: Bertels L et al. | Journal: Transplant Direct | Date: 2026-05-20
DOI: 10.1097/TXD.0000000000001936
TL;DR: 南非HIV陽性腎臟移植受者BK virus腎病發生率低(5%),大多數可保存移植腎,但資源匱乏導致監測延遲值得關注。
嘻嘻:—HIV陽性腎移植聽起來就很複雜,但BKV表現出奇地乖,出乎意料地令人欣慰。
Pulmonary Fungal Infections in Immunocompetent Patients¶
Authors: Arenas-Jiménez JJ et al. | Journal: J Thorac Imaging | Date: 2026-05-25
DOI: 10.1097/RTI.0000000000000889
TL;DR: 回顧免疫正常宿主的肺黴菌感染:地方性黴菌、部分Aspergillus表現及Cryptococcus gattii為主,臨床影像非特異性,地理旅遊史至關重要。
不嘻嘻:—免疫正常也會得黴菌感染還長得跟肺癌一樣,診斷科的折磨永無止境。
Surgical and Endovascular Management of Pseudoaneurysms of the Ascending Aorta and Aortic Root: Operative Strategies and Long-Term Outcomes¶
Authors: Abu Ghannam R et al. | Journal: Aorta (Stamford) | Date: 2026-05-24
DOI: 10.1055/a-2875-3047
TL;DR: 12例升主動脈假性動脈瘤回顧,41.6%為感染性,住院死亡率8.3%,一例晚期死於candidemia合併復發感染;外科仍為主要處置,高危患者可考慮血管內治療。
不嘻嘻:—感染加主動脈問題,外科已盡力,candidemia還是最後補刀,唉。
The risk of venous thromboembolism in kidney transplant recipients is enhanced following a cytomegalovirus infection¶
Authors: Masset C et al. | Journal: Front Immunol | Date: 2026-05-08
DOI: 10.3389/fimmu.2026.1816608
TL;DR: 法國多中心研究(15,433例腎移植)顯示CMV病毒血症顯著增加VTE風險(HR 1.61),有症狀CMV感染風險更高(HR 2.00),臨床應提高CMV相關血栓警覺。
嘻嘻:—CMV會造成血栓終於有大型隊列數字支持,以後跟病人解釋CMV有更多說服力了!
Clinical and computed tomography (CT) features of nodular pulmonary histoplasmosis¶
Authors: Li F et al. | Journal: J Thorac Dis | Date: 2026-04-24
DOI: 10.21037/jtd-2025-1-2659
TL;DR: 23例結節性肺histoplasmosis CT分析:以胸膜下孤立實心結節為主,多數無症狀、男性偏多,影像與肺腺癌難以鑑別,需結合流行病史。
不嘻嘻:—長得跟肺癌一模一樣,非地方性流行區的醫師每次診斷都要備受考驗。
Targeted Tuberculosis (TB) Vaccination Strategies in the United States: A Modeling Study¶
Authors: Rothman JE et al. | Journal: medRxiv | Date: 2026-05-14
DOI: 10.64898/2026.05.11.26352914
TL;DR: 美國TB疫苗策略建模:針對HIV感染者及非本地出生者等高風險族群定向接種,每年可減少51.8%病例(NNV 366),為M72/AS01E疫苗計畫提供量化依據。
嘻嘻:—TB疫苗快來了,建模說針對高風險族群可以砍掉一半的病例,太令人期待!
HOW TO INTRODUCE A NEW TB VACCINE IN ADOLESCENTS AND ADULTS: Insights from Key Stakeholders in Mozambique, Southern Africa¶
Authors: Lima AV et al. | Journal: medRxiv | Date: 2026-05-13
DOI: 10.64898/2026.05.10.26352803
TL;DR: 莫三比克利益關係人質性研究:TB新疫苗應優先HIV共病及糖尿病患者、密切接觸者,行動外展隊可提升覆蓋率,為低中收入國疫苗導入提供實務框架。
嘻嘻:—田野調查告訴我們如何實際推疫苗,這種接地氣的公衛研究最務實可愛!
Number Needed to Vaccinate with a Novel Tuberculosis Vaccine to Prevent Tuberculosis in High-Risk Populations, United States¶
Authors: Rothman JE et al. | Journal: medRxiv | Date: 2026-05-15
DOI: 10.64898/2026.05.11.26352950
TL;DR: M72/AS01類疫苗於美國高風險族群的TB預防NNV:HIV感染者僅217,與現有成人疫苗效率相當,支持定向接種優先HIV族群的策略。
嘻嘻:—NNV 217非常划算,針對HIV族群優先打TB疫苗是最CP值的做法!
A case of gastrointestinal tuberculosis in a 3-mo-old infant with profound immunodeficiency¶
Authors: Karanja-Chege C | Journal: J Hum Immun | Date: 2026-05-21
DOI: 10.70962/jhi.20250247
TL;DR: 3個月大先天免疫缺陷嬰兒罹患腸結核,術後仍發生短腸症候群及肝衰竭死亡,提醒嬰兒結核應積極評估潛在免疫缺陷。
不嘻嘻:—3個月大嬰兒、腸結核、先天免疫缺陷……每個字都令人心疼,這個案例很沉重。
Metabolomics and Artificial Intelligence (AI) assisted metabolomics in the diagnosis of non-tuberculous mycobacterial infections: progress and challenges¶
Authors: Murthy MK | Journal: New Microbes New Infect | Date: 2026-05-07
DOI: 10.1016/j.nmni.2026.101759
TL;DR: 回顧代謝體學及AI輔助代謝體學在NTM感染診斷的應用潛力,可彌補現有培養法不足,但標準化與技術挑戰仍需克服。
嘻嘻:—AI加入NTM診斷戰場,萬一能找到那個怎麼培養都不出來的菌,就太讚了!
🟢 One Health / Zoonoses¶
Hantavirus seroprevalence and associated factors for exposure in south-central Uganda¶
Authors: Katushabe G et al. | Journal: Emerg Microbes Infect | Date: 2026-05-24
DOI: 10.1080/22221751.2026.2665002
TL;DR: 烏干達南部1,199人調查顯示Orthohantavirus血清盛行率7.4%,男性及低社經地位者風險較高,當地人畜共通傳播長期被低估。
不嘻嘻:—接近1/10的人曾感染hantavirus且多數渾然不知,烏干達的鼠患問題絕非小事。
Aflatoxin health risk in the feed source: Integrated strategies for feed safety and sustainable One Health¶
Authors: Sharifi SD et al. | Journal: One Health | Date: 2026-05-08
DOI: 10.1016/j.onehlt.2026.101436
TL;DR: 回顧動物飼料中aflatoxin B1污染問題:肝毒性、免疫抑制與食品污染風險並存,提倡整合生物防治與嚴格監測的One Health策略。
不嘻嘻:—黃麴毒素從農田污染一路進到牛奶裡,食品安全鏈每個環節都有漏洞。
Human-animal contact and zoonotic exposure from wild and domestic animals: A cross-sectional study in wildlife-rich areas of Bolivia, Chile, and Guatemala¶
Authors: Kuhn C et al. | Journal: One Health | Date: 2026-05-08
DOI: 10.1016/j.onehlt.2026.101438
TL;DR: 拉丁美洲三國2,389人調查:92%有家畜接觸、32%有野生動物接觸,農村地區Brucella與牛結核暴露更高,青少年及低收入者風險顯著。
不嘻嘻:—幾乎每個人都在接觸動物,但幾乎沒人知道那暗藏什麼風險,公衛教育缺口很大。
Prevalence and antimicrobial susceptibility ofisolated from dairy goats in Shaanxi, China, with genomic characterization of a multidrug-resistant subset¶
Authors: Bai X et al. | Journal: One Health | Date: 2026-05-15
DOI: 10.1016/j.onehlt.2026.101443
TL;DR: 陝西乳羊奶Staphylococcus aureus盛行率10.7%,高風險株MRSA ST59及MSSA ST398與人及豬隻相關株具親緣關係,提示One Health框架下的跨宿主傳播。
不嘻嘻:—MRSA ST59和ST398出現在山羊奶裡,抗藥Staph無所不在,One Health的警訊很清楚。
Seasonal and spatial dynamics ofand antimicrobial resistance in a one health dairy ecosystem in Western Canada¶
Authors: Hoogstra S et al. | Journal: One Health | Date: 2026-05-12
DOI: 10.1016/j.onehlt.2026.101440
TL;DR: 加拿大西部乳牛場二年縱向研究:Enterococcus多達24種,AMR以四環素抗性為主,農場與廢水間的基因組連結有限,局部傳播為主。
嘻嘻:—乳牛場的Enterococcus沒有大量外流到廢水系統,比預期的乾淨一些,算是個好消息!
Transmission of severe fever with thrombocytopenia syndrome virus from a dog to humans and a cat in a household cluster¶
Authors: Ma D et al. | Journal: One Health | Date: 2026-05-05
DOI: 10.1016/j.onehlt.2026.101434
TL;DR: 首報家庭叢聚案例:愛犬感染SFTS病毒後傳染兩位飼主及同居貓咪,S段序列100%吻合,確認家庭環境為多向傳播樞紐,伴侶動物監測亟需強化。
不嘻嘻:—狗、主人、貓全家一起被SFTS攻陷,伴侶動物的傳播風險真的不能再被輕忽!
The First Global Forum of WHO Collaborating Centres and the One Health Summit, a landmark event redefining the future of global health science, with a reviewed history and update of the One Health concept¶
Authors: Mas-Coma S et al. | Journal: One Health | Date: 2026-05-10
DOI: 10.1016/j.onehlt.2026.101441
Seroincidence of Brucella spp. infection among humans and livestock in Northern Kenya¶
Authors: Mwatondo A et al. | Journal: Sci Rep | Date: 2026-05-24
DOI: 10.1038/s41598-026-52087-5
TL;DR: 肯亞北部牧民一年縱向研究:Brucella人類感染率0.057/人年,胎盤接觸、年齡及家畜確診為獨立危險因子,山羊感染率最高。
不嘻嘻:—接生家畜是Brucella的高危行為,但牧民又不得不接,這就是One Health的現實困境。
Descriptive Analysis of Imported Toxocariasis Cases Diagnosed Between 2014 and 2024 in an International Health Unit in Barcelona, Spain¶
Authors: Reynoso A et al. | Journal: Trop Med Int Health | Date: 2026-05-24
DOI: 10.1111/tmi.70169
TL;DR: 巴塞隆納十年87例進口型toxocariasis分析:94%為移民,74%有嗜酸性白血球增多,albendazole有效,提醒旅遊/移民嗜酸性白血球增多應納入鑑別診斷。
嘻嘻:—有eosinophilia又從疫區來的患者,記得想到Toxocara!簡單實用的臨床提醒。
Zoonotic cutaneous leishmaniasis caused by Leishmania major: Do humans play a role in amplifying transmission?¶
Authors: Aoun K et al. | Journal: Parasite | Date: 2026-05-25
DOI: 10.1051/parasite/2026030
TL;DR: 文獻回顧提出皮膚利什曼病傳播鏈中人類可能扮演輔助宿主角色,沙蠅攝食人類病灶後可攜帶具感染力的promastigote,挑戰百年傳統認知。
嘻嘻:—打破「只有沙鼠才是傳染源」的百年定論,人類也可能是共謀,反轉劇情有點刺激!
🟡 Food Security / Food Safety¶
Determinants of pesticide use and food safety awareness in a dryland vegetable system in Burao Somaliland using an exploratory value chain approach¶
Authors: Ongachi W et al. | Journal: Sci Rep | Date: 2026-05-24
DOI: 10.1038/s41598-026-54771-y
TL;DR: 索馬利蘭蔬菜農民及消費者調查:農業推廣服務有助減少農藥使用,消費者食品安全知識中等但擔憂高,非正規市場依賴和資訊匱乏為主要障礙。
不嘻嘻:—74%消費者依賴非正規市場且86%缺乏食品安全資訊,非洲食品鏈的脆弱讓人憂心。
Biological Control against Mycotoxigenic Fungi and Mycotoxins: Formulations, Challenges, and Future Prospects¶
Authors: Sinang FM et al. | Journal: J Appl Microbiol | Date: 2026-05-25
DOI: 10.1093/jambio/lxag125
TL;DR: 回顧對抗產毒黴菌的生物防治策略,包含微生物製劑配方技術(封裝化、聯合菌群)及精準農業整合,環境友善但製劑穩定性和田間效果仍有挑戰。
嘻嘻:—用好菌打壞黴菌又不汙染環境,生物防治概念很美好,希望能順利走出實驗室!
Serovar Distribution, Virulence Gene Profiles, and Antimicrobial Resistance ofIsolated from Chicken Meat from the Broiler Slaughterhouse and Processing Plant in Central Thailand¶
Authors: Pelyuntha W et al. | Journal: Foodborne Pathog Dis | Date: 2026-05-25
DOI: 10.1177/15353141261453452
TL;DR: 泰國屠宰場雞肉Salmonella盛行率21.9%,45%為多重抗藥株,S. Agona為主要血清型,ampicillin/streptomycin抗性最高,食品鏈管控需加強。
不嘻嘻:—幾乎一半的Salmonella都是MDR,而且來自屠宰場雞肉,這就是為什麼要把雞肉煮熟。
Enhanced Antimicrobial and Antidiabetic Activities ofandExtracts Toward Pathogenic Microorganisms: Phytochemical Profiling and Biomedical Applications¶
Authors: Gataa IS et al. | Journal: Foodborne Pathog Dis | Date: 2026-05-25
DOI: 10.1177/15353141261451629
TL;DR: 兩種植物萃取物聯合使用對多種食源性病原菌的MIC顯著低於單獨使用,兼具抗氧化與抑α-glucosidase活性,展示天然複方抗菌的應用潛力。
嘻嘻:—植物複方打細菌又抗糖尿病,天然萃取物的協同效應實驗數字看起來不錯!
A Hemicyanine-BODIPY-Based Dual-Channel Fluorescent Probe for Simultaneous Sensing of Sulfur Dioxide Derivatives and Viscosity¶
Authors: Guo L et al. | Journal: Anal Chem | Date: 2026-05-25
DOI: 10.1021/acs.analchem.6c02018
TL;DR: 開發雙通道螢光探針可同步偵測二氧化硫衍生物(LOD 12.6 nM)及黏度,整合智慧型手機平台可現場快速檢測食品及細胞,適用食品安全及生醫研究。
嘻嘻:—用手機就能測食品裡的SO2,化學分析走進日常生活的感覺,很有未來感!
A comparative approach for selecting orthologous candidate genes in GWAS across multiple species¶
Authors: Whitt L et al. | Journal: Plant Physiol | Date: 2026-05-25
DOI: 10.1093/plphys/kiag298
TL;DR: 提出跨物種GWAS方法FiReMAGE,在五種作物中識別控制微量元素積累的保守因果基因,可應用於改善作物食品安全及營養品質。
嘻嘻:—跨五物種GWAS找到保守基因,為作物育種提供新工具,離更健康的食物又近一步!
Recent Advances in Smartphone-Assisted Paper-Based Biosensors for Detection of Key Chemical Indicators in Spoilage of Meat and Seafood: Rapid and On-Site Analytical Method¶
Authors: AlMohamadi H et al. | Journal: Crit Rev Anal Chem | Date: 2026-05-25
DOI: 10.1080/10408347.2026.2673216
TL;DR: 回顧結合紙基生物感測器與智慧型手機偵測肉品及海鮮腐敗化學指標的新興技術,奈米材料整合實現現場快速分析,具食品安全管控應用潛力。
嘻嘻:—用手機掃一掃就知道魚肉是否腐敗,食安科技越來越貼近消費者了!
Rek-Surv: A lightweight deep survival model for plant infectious disease onset prediction¶
Authors: Xiao J et al. | Journal: Infect Dis Model | Date: 2026-03-04
DOI: 10.1016/j.idm.2026.03.001
TL;DR: 以Kolmogorov-Arnold Network為基礎的輕量存活分析模型Rek-Surv預測柑橘黃龍病發病時間,C-index 0.962且僅114個參數,可推廣至農業及醫學早期病害偵測。
嘻嘻:—114個參數達到0.962 C-index,AI在農業病害預測真是精準高效,名副其實的輕騎兵!
Recent advances in isothermal amplification techniques for detection of animal diseases¶
Authors: Tooryan F et al. | Journal: Front Vet Sci | Date: 2026-05-07
DOI: 10.3389/fvets.2026.1819190
TL;DR: 回顧等溫核酸擴增技術(LAMP、RPA等)在家畜及伴侶動物病原體偵測的應用,無需PCR儀器、現場適用,為資源有限環境的獸醫診斷提供新選擇。
嘻嘻:—不用PCR機器也能檢病原,對偏遠牧場的獸醫來說是真正的福音!
RustMAE: A Spatiotemporal Transformer for Short- to Medium-Term Warning of Wheat Stripe Rust Spring Spread¶
Authors: Zhang X et al. | Journal: iScience | Date: 2026-04-09
DOI: 10.1016/j.isci.2026.115666
TL;DR: 時空Transformer模型RustMAE預測小麥條紋銹病14天擴散,準確率87.23%、AUC 0.924,融合光學影像、SAR及氣象資料,為糧食安全提供精準早期預警。
嘻嘻:—衛星加AI對抗小麥銹病,糧食安全的科技守門員,農業也有高科技英雄了!
資料來源:PubMed (articles retrieved 2026-05-26)