Daily Journal Digest — 2026-05-19¶

過去 24 小時新增：Transplant ID × 25、One Health × 11、Food Security × 10，共 46 篇。

⭐ 今日亮點¶

European Recommendations for Transitioning the Care of Patients With Multiple Myeloma Treated With B-Cell Maturation Antigen Bispecific Antibodies From Academic Hospitals to Community-Based Centers and for Outpatient Step-Up Dosing
歐洲共識指引將BCMA雙特異抗體給藥移至門診，直接改變MM患者照護模式。
Nuclear transport of cytomegalovirus tegument protein pp65 through nucleoplasmic reticulum
高影響力期刊（PLoS Pathog）揭示HCMV入核新機制，具潛在抗病毒靶點意義。
Development of Machine Learning Models to Predict Candidemia in Hospitalized Adult Patients
AI模型利用電子病歷提前預測念珠菌血症，為感染科早期介入提供臨床決策工具。
Comparative genomic analysis of Acinetobacter baumannii isolates from seafood markets and healthcare environments: a case study from Kerala, India
海鮮市場與醫院鮑曼菌基因組高度同源，揭示食物鏈與院內AMR傳播的連結。
Whole-Genome Sequencing-Based Monitoring of Cronobacter sakazakii ST4 Persistence in an Irish Dairy Powder Facility
WGS確認嬰兒配方奶粉廠Cronobacter持續污染，對嬰兒食品安全具立即公衛警示意義。

🔴 Transplant & Opportunistic Infections¶

Nuclear transport of cytomegalovirus tegument protein pp65 through nucleoplasmic reticulum¶

Authors: Azzeh M et al. | Journal: PLoS Pathog | Date: 2026 05 18
DOI: 10.1371/journal.ppat.1014224
TL;DR: HCMV被膜蛋白pp65透過核質網絡入核的機制揭示病毒突破核膜屏障的新途徑。
評: 嘻嘻—病毒居然走秘密通道進細胞核，免疫學的黑盒子又開了一扇窗！

High incidence of low-level CMV viremia detected by droplet digital PCR after allogeneic hematopoietic stem cell transplantation¶

Authors: Li HL et al. | Journal: Transplant Cell Ther | Date: 2026 05 16
DOI: 10.1016/j.jtct.2026.05.017

Right parietal cryptococcoma in a young immunocompetent patient: illustrative case¶

Authors: Vasconcelos FA et al. | Journal: J Neurosurg Case Lessons | Date: 2026 05 18
DOI: 10.3171/CASE25713
TL;DR: 39歲免疫正常男性出現右頂葉隱球菌瘤，提醒臨床勿忽視非免疫缺乏者的CNS隱球菌感染。
評: 不嘻嘻—連「正常人」都中招，隱球菌真的不按牌理出牌。

Chainsaw culture: Cladophialophora bantiana cerebral abscess after chainsaw activity in an immunocompetent host. Illustrative case¶

Authors: Rendu VS et al. | Journal: J Neurosurg Case Lessons | Date: 2026 05 18
DOI: 10.3171/CASE25938
TL;DR: 免疫正常女性使用電鋸後感染C. bantiana腦膿瘍，死亡率高達70%，為澳洲第二例報告。
評: 不嘻嘻—用電鋸居然能帶進稀有致命黴菌，讓人不寒而慄。

Impact of climate, air pollution, and urbanization on chronic respiratory infections¶

Authors: Faverio P et al. | Journal: Expert Rev Respir Med | Date: 2026 05 18
DOI: 10.1080/17476348.2026.2675617
TL;DR: 氣候變遷、空氣污染及都市化加速慢性呼吸道感染惡化，對結構性肺病患者影響尤甚。
評: 不嘻嘻—環境越糟肺越難過，這是個沒有好消息的趨勢。

Neutrophil extracellular traps are found at epithelial barriers in canine sinonasal aspergillosis¶

Authors: Janssen P et al. | Journal: Front Immunol | Date: 2026 05 01
DOI: 10.3389/fimmu.2026.1808191
TL;DR: 犬鼻竇曲霉菌病中發現中性球胞外陷阱聚積於上皮屏障，揭示抗真菌免疫防禦新機制。
評: 嘻嘻—中性球放「陷阱網」抓真菌，免疫武器庫又多了一個酷炫成員！

Infection risk associated with teclistamab in relapsed/refractory multiple myeloma: a systematic review and meta-analysis of clinical trial and real-world evidence¶

Authors: Huang ZY et al. | Journal: Front Immunol | Date: 2026 04 30
DOI: 10.3389/fimmu.2026.1804838
TL;DR: Teclistamab治療復發難治多發性骨髓瘤時感染風險顯著，低丙球血症為主要機制。
評: 不嘻嘻—殺癌神器的代價是讓免疫系統幾乎繳械，感染問題不容小覷。

Isavuconazole therapeutic drug monitoring in real-world clinical practice: an age-stratified analysis of determinants¶

Authors: Tan Z et al. | Journal: Front Pharmacol | Date: 2026 04 30
DOI: 10.3389/fphar.2026.1779322
TL;DR: 真實世界分層分析顯示isavuconazole血中濃度受年齡影響，老年族群更需個別化TDM。
評: 嘻嘻—終於有數據支持老年患者isavuconazole需更細緻監測，藥師點頭稱是。

European Recommendations for Transitioning the Care of Patients With Multiple Myeloma Treated With B-Cell Maturation Antigen Bispecific Antibodies From Academic Hospitals to Community-Based Centers and for Outpatient Step-Up Dosing¶

Authors: Mateos MV et al. | Journal: EJHaem | Date: 2026 05 14
DOI: 10.1002/jha2.70290
TL;DR: 歐洲專家共識建議多發性骨髓瘤患者接受BCMA雙特異性抗體可安全於門診逐步給藥。
評: 嘻嘻—住院治療搬到門診，患者和家屬生活品質都大幅提升！

Aadhesin-like effector drives fitness and immunogenicity in the gut¶

Authors: Jensen O et al. | Journal: bioRxiv | Date: 2026 05 07
DOI: 10.64898/2026.05.04.722752
TL;DR: IgA是調控腸道Candida albicans定殖的關鍵，黏附素樣效應蛋白促進免疫逃脫與適應性。
評: 嘻嘻—白色念珠菌與IgA的貓鼠遊戲有了新線索，抗黴藥研發又有方向了！

Systematic Profiling of Essential Fungal Transcription Factors Uncovers Ezt1 as a Central Pathobiological and Morphogenic Regulator in¶

Authors: Lee SH et al. | Journal: bioRxiv | Date: 2026 05 05
DOI: 10.64898/2026.04.30.722081
TL;DR: 系統性篩選隱球菌必要轉錄因子發現Ezt1為核心致病與形態調控因子，具新藥靶潛力。
評: 嘻嘻—找到隱球菌的「關鍵開關」，新藥研發方向又明確了一些！

Anticryptococcal Evaluation of the Allylimine 3H2: Modulation of Virulence Traits and Synergistic Action with Amphotericin B¶

Authors: Magalhães TFF et al. | Journal: ACS Omega | Date: 2026 04 27
DOI: 10.1021/acsomega.6c01027
TL;DR: 新型烯丙亞胺化合物3H2對隱球菌具抗菌活性，與兩性黴素B具協同增效作用。
評: 嘻嘻—新骨架化合物加老將協同出擊，對抗隱球菌又多了一個候選武器！

Rapidly Progressive Mucormycosis Presenting as Giant Cell Arteritis as a First Presentation of Diabetes in a Woman With Diabetic Ketoacidosis: A Case Report and Review of the Literature¶

Authors: Nori S et al. | Journal: Case Rep Infect Dis | Date: 2026 05 13
DOI: 10.1155/crdi/4066148
TL;DR: 糖尿病酮酸中毒患者以巨細胞動脈炎表現為首發，確診後為播散性毛黴菌病，強調早診必要性。
評: 不嘻嘻—血糖失控加稀有黴菌，一次收穫兩個診斷噩夢，真的是陷阱中的陷阱。

Authors: Dsouza AC et al. | Journal: Orbit | Date: 2026 05 17
DOI: 10.1080/01676830.2026.2671182
TL;DR: COVID-19相關鼻眶腦毛黴菌病術後眼眶摘除倖存者的長期生活品質顯著受損。
評: 不嘻嘻—活下來了但代價是眼睛，這樣的存活真的很沉重。

Severe Pneumocystis jirovecii Pneumonia as the Sentinel Presentation of BENTA Disease: Case Report of a 3-month-old Infant¶

Authors: Rubio-Duarte AF et al. | Journal: Pediatr Infect Dis J | Date: 2026 05 18
DOI: 10.1097/INF.0000000000005288
TL;DR: 3個月嬰兒以嚴重PJP為首發確診BENTA罕見免疫缺乏病，PJP可作為原發免疫缺乏的哨兵事件。
評: 嘻嘻—嬰兒PJP揪出超罕見免疫缺乏，雖然辛苦但總算有了診斷！

Infection timing and immuno-inflammatory profiles determine prognosis of Pneumocystis jirovecii pneumonia in kidney transplant recipients¶

Authors: Wang S et al. | Journal: Ann Clin Microbiol Antimicrob | Date: 2026 05 17
DOI: 10.1186/s12941-026-00865-4
TL;DR: 腎移植受者PJP預後由感染時機與免疫炎症指標共同決定，視覺化列線圖可輔助臨床預測。
評: 嘻嘻—有列線圖工具幫助預測PJP預後，移植科醫師又多了一個實用武器！

Development of Machine Learning Models to Predict Candidemia in Hospitalized Adult Patients¶

Authors: Hashimoto K et al. | Journal: Kurume Med J | Date: 2026 05 15
DOI: 10.2739/kurumemedj.MS721234017
TL;DR: 機器學習模型利用電子病歷可提前預測住院患者念珠菌血症，具早期識別高風險族群潛力。
評: 嘻嘻—AI幫忙揪念珠菌血症，早發現早治療，感染科終於迎來智能助手！

Chronic pulmonary aspergillosis complicated by a lung abscess within a pulmonary cavity successfully treated with percutaneous drainage: A case report¶

Authors: Okazaki Y et al. | Journal: Intern Med | Date: 2026 05 16
DOI: 10.2169/internalmedicine.7229-26
TL;DR: 慢性肺麴菌病空洞內細菌性肺膿瘍以經皮引流成功治療，拓展侵入性處置適應症。
評: 嘻嘻—不用開刀戳一針就搞定，麴菌病的處置又多了一個好選擇！

Central Nervous System Post-Transplant Lymphoproliferative Disorder After Kidney Transplantation in an Epstein-Barr Virus-Seronegative Recipient Despite Serial EBV-DNA Monitoring: A Case Report¶

Authors: Shimogawa T et al. | Journal: Transplant Proc | Date: 2026 05 17
DOI: 10.1016/j.transproceed.2026.05.001
TL;DR: 腎移植後EBV陰性受者出現CNS PTLD，顯示連續EBV-DNA監測仍有偵測盲點。
評: 不嘻嘻—定期監測也可能漏掉，PTLD的黑天鵝在最讓人放心時出現。

Acquired immunodeficiency syndrome-associated cytomegalovirus encephalitis: clinical, imaging, and follow-up characteristics of 11 cases¶

Authors: Wu D et al. | Journal: Quant Imaging Med Surg | Date: 2026 04 13
DOI: 10.21037/qims-2025-aw-2399
TL;DR: 11例AIDS合併CMV腦炎分析：CD4<50時易發，死亡率高，MRI特徵有助早期診斷。
評: 不嘻嘻—CD4掉到谷底的患者腦子還要被CMV攻擊，預後真的很艱難。

Neurological manifestations in people with HIV in HAART era: a cross-sectional multicenter study¶

Authors: Lu L et al. | Journal: Front Neurol | Date: 2026 05 01
DOI: 10.3389/fneur.2026.1772052
TL;DR: HAART時代HIV患者神經系統併發症仍多元，認知障礙與周邊神經病變為主要負擔。
評: 不嘻嘻—有了抗愛滋藥神經問題還是沒消失，只是換了面孔繼續困擾患者。

Scaling Up Tuberculosis Preventive Treatment: Progress and Factors Influencing Optimization - China, 2022-2025¶

Authors: Xu C et al. | Journal: China CDC Wkly | Date: 2026 03 27
DOI: 10.46234/ccdcw2026.061
TL;DR: 中國2022至2025年結核預防性治療規模擴大，TPT整合入國家防控顯著提升LTBI處理率。
評: 嘻嘻—中國把結核預防治療推向全國，終止結核病的目標又近了一步！

HIV and Low Vision: A Narrative Review¶

Authors: Kumari R | Journal: Rom J Ophthalmol | Date: 2026
DOI: 10.22336/rjo.2026.04
TL;DR: 綜述HIV感染所致視力損害，CMV視網膜炎仍最常見，HAART顯著降低但未消除視力威脅。
評: 不嘻嘻—讓人看不見的病毒併發症，HAART雖改善了但仍困擾著許多HIV患者。

Evaluation of demographic and co-infection pattern amongst HIV seropositive individuals in a tertiary care centre¶

Authors: Gattani M et al. | Journal: Bioinformation | Date: 2026 03 31
DOI: 10.6026/973206300221469
TL;DR: 印度三級醫院HIV患者以結核菌及口腔念珠菌合併感染最常見，強調整合感染管理的重要性。
評: 不嘻嘻—TB加HIV加念珠菌的三重組合，在資源有限地區仍是沉重的日常現實。

Integrating meaningful involvement of people living with non-communicable diseases in India's National NCD Programme: lessons learnt and opportunities for global, regional and national contextualisation and adoption¶

Authors: Arora M et al. | Journal: BMJ Glob Health | Date: 2026 05 17
DOI: 10.1136/bmjgh-2025-020189
TL;DR: 印度國家非傳染病防治計畫納入患者有意義參與機制，提升政策落地效果與健康結果。
評: 嘻嘻—讓病人真正有發言權，政策才不會只是紙上談兵！

🟢 One Health / Zoonoses¶

What makes them stick? A genetic analysis of biofilm formation of an infective endocarditis-causingstrain using transposon directed insertion-site sequencing¶

Authors: Katsburg M et al. | Journal: Front Cell Infect Microbiol | Date: 2026 04 30
DOI: 10.3389/fcimb.2026.1777632
TL;DR: 轉座子插入定址定序鑑定人畜共通感染性心內膜炎病原的生物膜形成關鍵基因，揭示新治療靶點。
評: 嘻嘻—找到細菌「黏心臟」的遺傳密碼，未來或可靶向打擊！

Vitamin D metabolites reshape bovine mammary epithelial responses relevant to mastitis through host-directed mechanisms¶

Authors: Tiraboschi G et al. | Journal: Front Cell Infect Microbiol | Date: 2026 05 01
DOI: 10.3389/fcimb.2026.1815096
TL;DR: 維生素D代謝物增強乳牛乳腺上皮防禦反應，可作為乳腺炎減少抗生素使用的宿主導向策略。
評: 嘻嘻—維生素D幫母牛抵抗乳腺炎少用抗生素，One Health雙贏！

Comparative genomic analysis ofisolates from seafood markets and healthcare environments: a case study from Kerala, India¶

Authors: Patel JK et al. | Journal: JAC Antimicrob Resist | Date: 2026 05 15
DOI: 10.1093/jacamr/dlag060
TL;DR: 印度喀拉拉邦海鮮市場與醫院環境中A. baumannii基因組高度同源，揭示食品-醫療交叉傳播鏈。
評: 不嘻嘻—魚市場和ICU的鮑曼菌居然是親戚，AMR的傳播無所不在令人憂鬱。

Host-virus association databases as tools for understanding viral spillover at varying scales¶

Authors: Lindsley IC et al. | Journal: PLoS Negl Trop Dis | Date: 2026 05 18
DOI: 10.1371/journal.pntd.0013343
TL;DR: 宿主-病毒資料庫是研究病毒跨物種溢出的重要工具，但需注意資料品質與分析尺度局限。
評: 嘻嘻—有了更好的資料庫工具，預測下一個病毒跳物種的能力又進步了！

Systematic review of health risk assessment in Africa's bushmeat trade: Are there any risks assessed?¶

Authors: Amougou CV et al. | Journal: PLoS Negl Trop Dis | Date: 2026 05 18
DOI: 10.1371/journal.pntd.0014308
TL;DR: 系統回顧顯示非洲叢林肉貿易的人畜共通病健康風險評估嚴重不足，預防機制存在重大缺口。
評: 不嘻嘻—叢林肉貿易是病毒溢出溫床，但風險評估幾乎是空白，好擔心。

A Scoping Review of Machine Learning Applications Across Epidemiological Stages of Zoonotic Disease¶

Authors: Zhang Y et al. | Journal: Transbound Emerg Dis | Date: 2026 05 14
DOI: 10.1155/tbed/2215823
TL;DR: 機器學習應用於人畜共通疾病各流行病學階段的範疇回顧，展示AI在動物到人傳播防控的潛力。
評: 嘻嘻—AI從動物到人全程追蹤人畜共通病，防控工具箱又升級了！

Genomic and Pathogenic Characterization of an Extensively Drug-Resistant Avian PathogenicStrain¶

Authors: Ni W et al. | Journal: Transbound Emerg Dis | Date: 2026 05 14
DOI: 10.1155/tbed/4233989
TL;DR: 中國肉雞分離出廣泛耐藥禽致病性E. coli，基因組揭示多種AMR機制，公衛威脅不容忽視。
評: 不嘻嘻—禽場超級細菌越來越厲害，雞肉生產的AMR問題讓人坐立不安。

Comparative Human-Poultry Fecal Resistome Profiling from Broiler Farms Reveals Diverse Antimicrobial Resistance Genes¶

Authors: Sreekumaran S et al. | Journal: Foodborne Pathog Dis | Date: 2026 05 18
DOI: 10.1177/15353141261449964
TL;DR: 肉雞農場人禽糞便抗藥基因組比較顯示AMR基因跨物種共享，農場工人為高風險暴露族群。
評: 不嘻嘻—人和雞分享了AMR基因，農場真的是抗藥性重要孵化場。

Cruise Ships as Amplifiers of Emerging Zoonotic Threats: Implications of the Suspected Andes Hantavirus Cluster aboard MV Hondius¶

Authors: Thaledi S et al. | Journal: J Travel Med | Date: 2026 05 18
DOI: 10.1093/jtm/taag034

Occurrence, antimicrobial resistance and molecular characterization of Salmonella spp. from broiler chickens in Northern Algeria¶

Authors: Cartelo LA et al. | Journal: Braz J Microbiol | Date: 2026 05 18
DOI: 10.1007/s42770-026-01965-1
TL;DR: 阿爾及利亞北部肉雞Salmonella流行率高且多具抗藥性，分子特徵揭示顯著的公共衛生風險。
評: 不嘻嘻—北非雞肉Salmonella問題又多了個數據點，食安壓力持續累積。

A risk assessment of the environmental and clinical implications of aquaculture-associated, multidrug-resistant Aeromonas veronii¶

Authors: Zheng B et al. | Journal: Water Res | Date: 2026 05 04
DOI: 10.1016/j.watres.2026.126007
TL;DR: 水產養殖中多重耐藥Aeromonas veronii攜帶多種可移動ARG，對環境與臨床均構成雙重威脅。
評: 不嘻嘻—養魚場的細菌同時威脅魚和人，AMR問題在水面下悄悄發酵。

🟡 Food Security / Food Safety¶

Magnetic field-assisted freezing mitigates quality deterioration in oyster meat (Crassostrea hongkongensis) by inducing the formation of uniform ice crystals and preserving water-holding capacity¶

Authors: Jian W et al. | Journal: Food Chem | Date: 2026 05 15
DOI: 10.1016/j.foodchem.2026.149645
TL;DR: 磁場輔助冷凍技術可減少生蠔冰晶損傷並保持保水性，顯著優於傳統冷凍保鮮效果。
評: 嘻嘻—磁場凍蠔！食品科技的腦洞開越來越大，保鮮還能這麼玩！

A web-based platform for real-time stewed beef freshness monitoring: Integrating anthocyanin colorimetric film with deep learning¶

Authors: He N et al. | Journal: Food Chem | Date: 2026 05 15
DOI: 10.1016/j.foodchem.2026.149643
TL;DR: 整合花青素變色薄膜與深度學習的網路平台可即時監測紅燒牛肉新鮮度，感測準確率高。
評: 嘻嘻—AI加顏色變化薄膜幫你判斷牛肉有沒有壞，食安監控又科幻了起來！

Revealing the impact of low-temperature fermentation by Weissella cibaria MXJSHZ8-3 on soymilk quality through volatile flavor compounds and metabolite profiles¶

Authors: Lin Y et al. | Journal: Food Chem | Date: 2026 05 12
DOI: 10.1016/j.foodchem.2026.149604
TL;DR: 低溫適應乳酸菌Weissella cibaria發酵豆漿可改善揮發性香氣與代謝物組成，提升整體品質。
評: 嘻嘻—低溫菌讓豆漿更香更好，食品科學在細節裡大有文章！

The carbon starvation-inducible lipoprotein (Slp) influences differential adherence of Escherichia coli O157:H7 at the bovine rectoanal junction¶

Authors: Kudva IT et al. | Journal: PLoS Pathog | Date: 2026 05 18
DOI: 10.1371/journal.ppat.1013584
TL;DR: 碳源饑餓誘導脂蛋白Slp調控O157:H7在牛直腸肛門交界處的差異性黏附，揭示持久性定殖機制。
評: 嘻嘻—找到O157:H7在牛體內「安家」的關鍵蛋白，防控策略又有新靶點！

Reinforcing the Arsenal: Advanced Antibiotic Adjuvants as Strategic Disruptors of Bacterial Defenses¶

Authors: Dong J et al. | Journal: J Agric Food Chem | Date: 2026 05 18
DOI: 10.1021/acs.jafc.6c01244
TL;DR: 新型抗生素佐劑透過干擾外排泵、生物膜及外膜完整性強化現有抗生素療效，提供新AMR應對策略。
評: 嘻嘻—不用研發新抗生素，幫舊藥找助攻就能克服抗藥性，思路很聰明！

Exploring bet-hedging inserovar Typhimurium with a dual reporter strain¶

Authors: Gerber MI et al. | Journal: mSystems | Date: 2026 05 18
DOI: 10.1128/msystems.00177-26
TL;DR: Salmonella Typhimurium以下注避險策略調控CsgD雙態生物膜形成，解釋宿主-環境轉換適應機制。
評: 嘻嘻—細菌懂「不把雞蛋放同一個籃子」，進化智慧令人拍案叫絕！

Occurrence of multidrug-resistant extended-spectrum β-lactamase (ESBL)-producingin fecal and environmental samples from Belgian livestock farms¶

Authors: Lambrecht E et al. | Journal: Microbiol Spectr | Date: 2026 05 18
DOI: 10.1128/spectrum.03591-25
TL;DR: 比利時牧場動物糞便與環境中廣泛檢出ESBL產酶菌，農業AMR管控亟需系統性強化。
評: 不嘻嘻—歐洲農場的ESBL問題也不樂觀，AMR在食物鏈裡流竄已是全球現象。

Metagenomic profiling of bacterial (16S) and fungal (ITS) communities on d'Anjou pears during long-term controlled-atmosphere storage¶

Authors: Raad R et al. | Journal: Microbiol Spectr | Date: 2026 05 18
DOI: 10.1128/spectrum.04117-25
TL;DR: 長期控制氣氛貯藏安茹梨的細菌與真菌菌群隨時間演替，為採後病害防控提供微生態依據。
評: 嘻嘻—水果表面的微生物世界宏基因組學讓我們終於看清楚，保存品質有了科學基礎！

Fermented Foods and Beverages of Ethiopia: Substrates, Traditional Preparation Techniques, and Nutritional Quality¶

Authors: Worku LA et al. | Journal: Food Sci Nutr | Date: 2026 05 13
DOI: 10.1002/fsn3.71887
TL;DR: 衣索比亞傳統發酵食品（苔麩薄餅、大麥酒等）具高營養潛力，為當地糧食安全的重要文化資產。
評: 嘻嘻—古老飲食智慧的科學價值獲認可，傳統食物原來比我們以為的更厲害！

Whole-Genome Sequencing-Based Monitoring ofST4 Persistence in an Irish Dairy Powder Facility¶

Authors: Hao Q et al. | Journal: Food Sci Nutr | Date: 2026 05 15
DOI: 10.1002/fsn3.71717
TL;DR: 全基因組定序監測愛爾蘭乳粉廠Cronobacter sakazakii ST4持續存在，揭示嬰兒配方奶粉生產風險。
評: 不嘻嘻—嬰兒奶粉廠潛伏的克洛諾桿菌WGS幫找出來，但問題仍令人高度警戒。

資料來源：PubMed (articles retrieved 2026-05-19)